(2E,6E)-1,8-diphenylocta-2,6-diene-1,8-dione | 182888-28-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2E,6E)-1,8-diphenylocta-2,6-diene-1,8-dione
• CAS: 182888-28-4
• 化学式: C₂₀H₁₈O₂
• 分子量: 290.362
• InChiKey: BXNSAVIURBRHIF-KAVGSWPWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2E,6E)-1,8-diphenylocta-2,6-diene-1,8-dione 在 三氟化硼乙醚 作用下， 以 甲醇 、 水 为溶剂， 反应 19.0h， 生成 1-methyl-2,5-bis(2-phenethyl)pyrrolidine hydrochloride
  参考文献：
  名称：

  Solvent-free double aza-Michael under ultrasound irradiation: diastereoselective sequential one-pot synthesis of pyrrolidine Lobelia alkaloids analogues

  摘要：

  新颖的 2,5-甲磺酰基吡咯烷是用容易获得的对称双迈克尔受体直接合成的。关键步骤是将伯烷基胺与双烯酮进行杂-迈克尔加成反应。Rauhut-Currier 和 aza-Michael 反应在质子溶剂中具有很强的竞争性。在无溶剂条件下进行超声波活化，可以获得预期的吡咯烷类化合物，产量高，立体选择性好。优化后的条件已扩展到短序列吡咯烷洛贝生物碱类似物的超声化学合成。

  DOI：

  10.1039/c2ob25963j
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 (2E,6E)-1,8-diphenylocta-2,6-diene-1,8-dione
  参考文献：
  名称：

  Balance-equation approach to terahertz-field-driven magnetotransport in semiconductors

  摘要：

  We investigate the magnetotransport in semiconductors under the influence of a de or slowly-varying electric field, an intense polarized. radiation field of terahertz frequency, and a uniform magnetic field, being in arbitrary directions and having arbitrary strengths. Effective force- and energy-balance equations are derived by using a gauge that the magnetic field and the high-frequency radiation field are described by a vector potential and the de or slowly-varying field by a scalar potential, and by distinguishing the slowly-varying velocity from the rapidly-oscillating velocity related to the high-frequency field. These equations, which include the elastic photos process and;all orders of multiphoton absorption and emission processes, are applied to the examination of the effect of a terahertz radiation on the magnetophonon resonance of the longitudinal resistivity in the transverse configuration in nonpolar and polar semiconductors. We find that the previous zero-photon resonance peaks are suppressed by the irradiation of the terahertz field, while many new peaks, which may be related to multiphoton absorption and emission processes, emerge and can become quite distinct, at moderately strong radiation field.

  DOI：

  10.1007/s100510050032

文献信息

• Indium(III) Acetate-Catalyzed 1,4-Reduction and Reductive Aldol Reactions of α-Enones with Phenylsilane
  作者：Katsukiyo Miura、Akira Hosomi、Yusuke Yamada、Mitsuru Tomita

  DOI：10.1055/s-2004-830862

  日期：——

  A catalytic amount of In(OAc) 3 smoothly promoted 1,4-reduction of certain α-enones with PhSiH 3 in ethanol at ambient temperature. The intermediary enolates could be used for inter- and intramolecular aldol reactions andintramolecular Michael addition.

  在环境温度下，催化量的 In(OAc) 3 在乙醇中顺利促进某些 α-烯酮与 PhSiH 3 的 1,4-还原。中间体烯醇化物可用于分子间和分子内醛醇反应和分子内迈克尔加成。
• A short synthetic route to the tricyclic guanidinium core of the batzelladine alkaloids
  作者：Gregory P. Black、Patrick J. Murphy、Nigel D.A. Walshe

  DOI：10.1016/s0040-4020(98)00576-6

  日期：1998.8

  addition of guanidine to a series of bis-α,β-unsaturated ketones is reported leading to the formation of tricyclic guanidines, which are models of the naturally occurring batzelladine alkaloids. Nmr evidence is given in support of a new assignment for the relative stereochemistry of batzelladine F.

  据报道，向一系列双-α，β-不饱和酮中添加胍可导致三环胍的形成，三环胍是天然巴兹拉定生物碱的模型。提供了Nmr证据来支持巴茨拉定F的相对立体化学的新任务。
• A Highly Nucleophilic Multifunctional Chiral Phosphane-Catalyzed Asymmetric Intramolecular Rauhut-Currier Reaction
  作者：Xiao-Nan Zhang、Min Shi

  DOI：10.1002/ejoc.201200940

  日期：2012.11

  An asymmetric variant of the intramolecular Rauhut–Currier (RC) reaction can be achieved using a highly nucleophilic multifunctional chiral phosphane; the corresponding cyclopentene and cyclohexene derivatives are produced in moderate to good yields and with good to excellent enantioselectivities.

  使用高度亲核的多功能手性磷烷可以实现分子内 Rauhut-Currier (RC) 反应的不对称变体；相应的环戊烯和环己烯衍生物以中等至良好的收率和良好至极好的对映选择性生产。
• Enantioselective Catalysis of Intramolecular Morita-Baylis-Hillman and Related Reactions by Chiral Rhenium-Containing Phosphines of the Formula (η⁵-C₅H₅)Re(NO)(PPh₃)(CH₂PAr₂)
  作者：John Gladysz、Florian Seidel

  DOI：10.1055/s-2007-973859

  日期：2007.4

  phosphine (η 5 -C 5 H 5 )Re(NO)(PPh 3 )(CH 2 PPh 2 ) catalyzes intramolecular Morita-Baylis-Hillman reactions of four R(CO)CH=CH(CH 2 ) n CH 2 CHO species (n = 1 or 2; R = Ph, S- I-Pr, P-Tol, Me) in benzene or chlorobenzene at 20 °C. The products R(CO)CH=CH(CH 2 ) n CH 2 CHOH are isolated in 88-99% yields and 38-74% ee when enantiopure S-configured catalyst is used. Similar reactions of R(CO)CH=CHCH 2 CH 2

  外消旋含铼膦 (η 5 -C 5 H 5 )Re(NO)(PPh 3 )(CH 2 PPh 2 ) 催化四种 R(CO)CH=CH(CH 2 ) 分子内 Morita-Baylis-Hillman 反应n CH 2 CHO 物质（n = 1 或 2；R = Ph、S-I-Pr、P-Tol、Me）在 20 °C 的苯或氯苯中。当使用对映纯的 S 型催化剂时，产物 R(CO)CH=CH(CH 2 ) n CH 2 CHOH 以 88-99% 的产率和 38-74% 的 ee 分离。R(CO)CH=CHCH 2 CH 2 CH=CH(CO)R (R = Ph, S-I-Pr) 的类似反应在 63 中得到 R(CO)C=CHCH 2 CH 2 CHCH 2 (CO)R -87% 产率和 42-56% ee。
• Rh(I)-catalyzed conjugate addition of alkenylzirconocene chloride: stereoselective formation of carbocycles through cascade reaction
  作者：Yuji Hanzawa、Yoshitaka Takebe、Akio Saito、Akito Kakuuchi、Haruhiko Fukaya

  DOI：10.1016/j.tetlet.2007.07.056

  日期：2007.9

  Stereoselective formation of carbocycles was carried out through [RhCl(cod)]2-catalyzed reactions of alkenylzirconocene chloride to ω-carbonyl-α,β-ene carbonyls (ketone, ester, and amide) or to bis-enone derivatives. The Rh(I)-catalyzed reaction of alkenylzirconocene chloride with ω-carbonyl-α,β-enoyl amide, which is derived from Oppolzer’s sultam, showed high diastereoselectivity to yield an carbocycle (95%

  通过[RhCl（cod）] 2催化的烯基锆茂氯化物与ω-羰基-α，β-烯羰基（酮，酯和酰胺）或双烯酮衍生物的立体选择形成碳环。Oppolzer's sultam衍生的链烯基锆茂金属氯化物与ω-羰基-α，β-烯丙基酰胺的Rh（I）催化反应显示出高非对映选择性，可产生碳环（95％收率，> 95％de）。