2,3-bis(4-fluorophenyl)pyrido[2,3-b]pyrazine | 149159-43-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶吡嗪类
• 英文名称: 2,3-bis(4-fluorophenyl)pyrido[2,3-b]pyrazine
• CAS: 149159-43-3
• 化学式: C₁₉H₁₁F₂N₃
• 分子量: 319.313
• InChiKey: NTOCEJPHYKUUAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-二氨基吡啶 、 4,4'-二氟苯偶酰 在 SBA-15 mesoporous silica supported Fe(III)-Schiff base 作用下， 以 水 为溶剂， 反应 2.0h， 以97%的产率得到2,3-bis(4-fluorophenyl)pyrido[2,3-b]pyrazine
  参考文献：
  名称：

  An iron Schiff base complex loaded mesoporous silica nanoreactor as a catalyst for the synthesis of pyrazine-based heterocycles

  摘要：

  一种铁Schiff碱复合物被包裹在SBA-15介孔硅胶中，以得到Fe(III)-Schiff碱/SBA-15异质纳米催化剂，用于合成吡啶并吡嗪和喹嗪烯杂环。这些反应在水中进行，产率极高。催化剂通过物理化学和光谱方法进行了表征，结果发现其保留了SBA-15的特征通道结构，允许被包裹的金属复合物良好的可及性。

  DOI：

  10.1007/s11243-013-9772-y

文献信息

• Organic Light-Emitting Element, Organometallic Complex, Light-Emitting Device, Electronic Appliance, and Lighting Device
  申请人：Inoue Hideko

  公开号：US20120264936A1

  公开（公告）日：2012-10-18

  Disclosed is a phosphorescent organometallic complex having: a 6-membered aromatic heterocycle having a nitrogen atom; iridium or platinum to which the nitrogen atom coordinates; and an aryl group which is bonded to an α-carbon of the nitrogen atom and is ortho-metalated with the iridium or platinum, where at least one of the aromatic heterocycle and the aryl group has an alicyclic hydrocarbon having an intramolecular carbon-carbon bridged bond as a substituent. The ability of the bulky structure of the alicyclic hydrocarbon to inhibit aggregation of the organometallic complex, concerted with the strong electron-donating property of the alicyclic hydrocarbon to the aromatic heterocycle or the aryl group, contributes to the increase in absorption coefficient and phosphorescent efficiency of the organometallic complex. The improved absorption coefficient and the phosphorescent efficiency allow the formation of a light-emitting element with excellent external quantum efficiency over 25%.

  本发明揭示了一种磷光有机金属配合物，其具有：含有氮原子的6元芳香杂环；氮原子与铱或铂配位；以及与氮原子的α-碳键合并与铱或铂发生邻位金属化的芳基基团，其中至少有芳香杂环和芳基基团中的一个具有作为取代基的脂环烃，其具有分子内碳-碳桥键。脂环烃的臃肿结构能够抑制有机金属配合物的聚集，与脂环烃对芳香杂环或芳基基团的强电子给体性质协同作用，有助于提高有机金属配合物的吸收系数和磷光效率。改进的吸收系数和磷光效率使得形成的发光元件具有优异的外部量子效率超过25%。
• HETEROCYCLIC COMPOUND
  申请人：Osaka Harue

  公开号：US20120197020A1

  公开（公告）日：2012-08-02

  Provided is a novel heterocyclic compound which can be used for a light-emitting element, as a host material of a light-emitting layer in which a light-emitting substance is dispersed. A heterocyclic compound represented by a general formula (G1) is provided. In the formula, A represents any of a substituted or unsubstituted dibenzothiophenyl group, a substituted or unsubstituted dibenzofuranyl group, and a substituted or unsubstituted carbazolyl group, R 11 to R 19 separately represent any of hydrogen, an alkyl group having 1 to 4 carbon atoms, and a substituted or unsubstituted aryl group having 6 to 14 carbon atoms, and Ar represents a substituted or unsubstituted arylene group having 6 to 13 carbon atoms.

  提供了一种新颖的杂环化合物，可用作发光元件，作为发光物质分散的发光层中的主体材料。提供了一个由通式（G1）表示的杂环化合物。在该式中，A代表取代或未取代的二苯并噻吩基团、取代或未取代的二苯并呋喃基团和取代或未取代的咔唑基团，R11至R19分别代表氢、具有1至4个碳原子的烷基基团，以及具有6至14个碳原子的取代或未取代的芳基基团，Ar代表具有6至13个碳原子的取代或未取代的芳基烯基团。
• Polyethylene glycol in water: A simple, efficient and green protocol for the synthesis of quinoxalines
  作者：HEMANT V CHAVAN、LAXMAN K ADSUL、BABASAHEB P BANDGAR

  DOI：10.1007/s12039-011-0081-8

  日期：2011.7

  quinoxaline derivatives has been efficiently synthesized in excellent yields under extremely mild conditions using PEG-600 and water. This inexpensive, non-toxic, eco-friendly and readily available system efficiently condensed several aromatic as well as aliphatic 1,2-diketones with aromatic and aliphatic 1,2-diamines to afford the products in excellent yield. Polyethylene glycol (PEG) can be recovered and

  使用PEG-600和水，已在极其温和的条件下以优异的收率高效合成了多种生物学上重要的喹喔啉衍生物。这种廉价，无毒，环保且易于获得的系统可将几种芳香族以及脂肪族1,2-二酮与芳香族和脂肪族1,2-二胺有效缩合，从而以优异的收率提供产品。聚乙二醇（PEG）可以回收再利用。 具有重要生物学意义的喹喔啉衍生物已使用PEG-600和水在极温和的条件下以高收率高效合成。
• Zirconium Schiff-Base Complex Modified Mesoporous Silica as an Efficient Catalyst for the Synthesis of Nitrogen Containing Pyrazine Based Heterocycles
  作者：Reihaneh Malakooti、Ghasem Rezanejade Bardajee、Hesamaldin Mahmoudi、Nahale Kakavand

  DOI：10.1007/s10562-013-0999-1

  日期：2013.8

  Zirconium Schiff-base complex modified SBA-15 was synthesized and characterized by powder X-ray diffraction (XRD), BET nitrogen adsorption–desorption methods, IR spectroscopy and thermogravimetric analysis. The XRD and BET analyses show that textural properties of SBA-15 were retained during the grafting procedure. The modified SBA was successfully applied as a heterogeneous catalyst for the synthesis

  合成了锆席夫碱配合物改性的 SBA-15，并通过粉末 X 射线衍射 (XRD)、BET 氮吸附-解吸方法、红外光谱和热重分析进行了表征。XRD 和 BET 分析表明 SBA-15 的结构特性在接枝过程中得以保留。改性的 SBA 作为多相催化剂成功应用于合成含氮吡嗪基杂环库，在水介质中以良好的收率。图文摘要锆席夫碱配合物改性介孔二氧化硅作为合成含氮杂环的有效催化剂吡嗪基杂环
• ZrOCl2·8H2O in water: An efficient catalyst for rapid one-pot synthesis of pyridopyrazines, pyrazines and 2,3-disubstituted quinoxalines
  作者：Ghasem Rezanejade Bardajee

  DOI：10.1016/j.crci.2013.02.018

  日期：2013.10

  Zirconium(IV) oxide chloride was found to be a rapid and efficient catalyst for the synthesis of pyrazines and 2,3-disubstituted quinoxalines in water. A variety of pyridopyrazine and 2,3-disubstituted quinoxaline derivatives are readily prepared in high yields under green conditions by cyclocondensation of the desired 1,2-diamine and 1,2-diketone using a catalytic amount of zirconium(IV) oxide chloride

  摘要 氧化锆 (IV) 氯化锆被发现是一种快速有效的催化剂，可用于在水中合成吡嗪和 2,3-二取代喹喔啉。多种吡啶并吡嗪和 2,3-二取代喹喔啉衍生物可在绿色条件下通过所需的 1,2-二胺和 1,2-二酮使用催化量的氧化锆 (IV) 在水中进行环缩合而以高产率轻松制备. 活性较低的二胺，例如 2,3-和 3,4-二氨基吡啶参与了该协议，以提供具有良好到优异产率的所需产品。