2-(2-cyclohexylethyl)-3H-imidazo[4,5-b]pyridine | 1291438-38-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 2-(2-cyclohexylethyl)-3H-imidazo[4,5-b]pyridine
• 英文别名: 2-(2-cyclohexylethyl)-1H-imidazo[4,5-b]pyridine
• CAS: 1291438-38-4
• 化学式: C₁₄H₁₉N₃
• mdl: MFCD16239453
• 分子量: 229.325
• InChiKey: FQHCBPZKPXDTIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,3-二氨基吡啶 、 3-环己基丙酸 以 二乙二醇二甲醚 为溶剂， 反应 3.0h， 以94%的产率得到2-(2-cyclohexylethyl)-3H-imidazo[4,5-b]pyridine
  参考文献：
  名称：

  Synthesis of novel 3-cyclohexylpropanoic acid-derived nitrogen heterocyclic compounds and their evaluation for tuberculostatic activity

  摘要：

  A series of novel 3-cyclohexylpropanoic acid derivatives and 3-cyclohexylpropanoic acid-derived nitrogen heterocyclic compounds (1-8) have been synthesized and evaluated for tuberculostatic activity. Compounds 1a, 1c, 1e and 1f bearing benzimidazole or benzimidazole-like systems showed the most potent tuberculostatic activity against Mycobacterium tuberculosis strains with MIC values ranging from 1.5 to 12.5 mu g/mL. More importantly 1a (6-chloro-2-(2-cyclohexylethyl)-4-nitro-1H-benzo[d]imidazole) and 1f (2-(2-cyclohexylethyl)-1H-imidazo[4,5-b]phenazine) appeared selective for M. tuberculosis as compared with eukaryotic cells (human fibroblasts), and other antimicrobial strains. These compounds may thus represent a novel, selective class of antitubercular agents. Additionally compound 1a stimulated type I collagen output by fibroblasts, in vitro. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.11.020