1,2,3-tris-salicyloyloxy-propane | 22576-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,2,3-tris-salicyloyloxy-propane
• 英文别名: 1,2,3-Tris-salicyloyloxy-propan；Glycerintrisalicylat；Trisalicylin；2,3-Bis[(2-hydroxybenzoyl)oxy]propyl 2-hydroxybenzoate
• CAS: 22576-79-0
• 化学式: C₂₄H₂₀O₉
• 分子量: 452.417
• InChiKey: NCEYCHHUCOMFPF-UHFFFAOYSA-N

物化性质

• 熔点：
  188-200 °C
• 沸点：
  662.6±50.0 °C(Predicted)
• 密度：
  1.411±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  33
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  140
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  sodium salicylate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 1,2,3-tris-salicyloyloxy-propane
  参考文献：
  名称：

  Fritsch, Chemische Berichte, 1891, vol. 24, p. 776

  摘要：

  DOI：

文献信息

• Poly(glycerol sebacate)-interleukin inhibitor copolymers and methods of making and use
  申请人：THE SECANT GROUP, LLC

  公开号：US10822450B2

  公开（公告）日：2020-11-03

  A method of preparing a polymeric material includes combining a glycerol-pharmaceutical conjugate, glycerol, and water in a vessel. The glycerol-pharmaceutical conjugate includes a pharmaceutical compound, for example, salicylic acid, having at least one carboxyl group attached to glycerol by an ester bond. The method also includes adding sebacic acid to the vessel and removing water from the vessel and reacting the glycerol, glycerol-pharmaceutical conjugate, and sebacic acid in the vessel at atmospheric pressure in the presence of an inert gas. The method further includes applying a sub-atmospheric pressure to the vessel after the step of reacting, to form the polymeric material in the vessel. The polymeric material includes a polyester copolymer of the sebacic acid and the glycerol and the pharmaceutical compound.

  制备聚合物材料的方法包括在容器中混合甘油-药物共轭物、甘油和水。甘油-药物共轭物包括药物化合物，例如水杨酸，其至少有一个羧基通过酯键连接到甘油上。该方法还包括向容器中加入癸二酸，从容器中除去水，并在惰性气体存在下，在常压下使容器中的甘油、甘油-药物共轭物和癸二酸反应。该方法还包括在反应步骤后对容器施加亚大气压，以在容器中形成聚合材料。聚合材料包括癸二酸、甘油和药物化合物的聚酯共聚物。
• DE58396
  申请人：——

  公开号：——

  公开（公告）日：——
• GLYCERYL AND GLYCOL ACID COMPOUNDS
  申请人：Mentlik A. Anton

  公开号：US20070269391A1

  公开（公告）日：2007-11-22

  A composition comprising a glyceryl salicylate compound and/or a glycol salicylate compound. The compositions can be used to reduce the amount of moisture evaporated from skin, protect the skin from UV light, and treat aged or damaged skin.
• POLY(GLYCEROL SEBACATE)-INTERLEUKIN INHIBITOR COPOLYMERS AND METHODS OF MAKING AND USE
  申请人：THE SECANT GROUP, LLC

  公开号：US20190016854A1

  公开（公告）日：2019-01-17

  A method includes combining an alcohol-pharmaceutical conjugate, a polyol, and an aqueous liquid in a vessel. The alcohol-pharmaceutical conjugate includes a pharmaceutical compound having at least one carboxyl group attached to the polyol by an ester bond. The method also includes adding an acid monomer to the vessel and heating and removing water from the vessel to produce the polymeric material. The polymeric material includes a polyester copolymer of the acid monomer and the polyol and the pharmaceutical compound.
• US7932417B2
  申请人：——

  公开号：US7932417B2

  公开（公告）日：2011-04-26