4-carboxymethyl-benzenediazonium chloride | 55863-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-carboxymethyl-benzenediazonium chloride
• 英文别名: 4-(Carboxymethyl)benzenediazonium;chloride
• CAS: 55863-27-9
• 化学式: C₈H₇N₂O₂*Cl
• 分子量: 198.609
• InChiKey: COOCQBSSFOREMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  65.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  sodium salicylate 、 4-carboxymethyl-benzenediazonium chloride 在 sodium hydroxide 、 盐酸 作用下， 以 水 为溶剂， 反应 0.5h， 生成 5-(4-carboxymethyl-phenylazo)-2-hydroxy-benzoic acid
  参考文献：
  名称：

  Methods and compositions employing 4-aminophenylacetic acid compounds

  摘要：

  本发明提供了包含4-APAA化合物的组合物以及治疗涉及消化系统和/或黏膜组织炎症的疾病的方法，例如炎性肠病。本发明的方法和组合物还包括4-APAA化合物和5-ASA化合物的组合治疗此类疾病。

  公开号：

  US20070060552A1
• 作为产物：
  描述：

  对氨基苯乙酸 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 0.33h， 生成 4-carboxymethyl-benzenediazonium chloride
  参考文献：
  名称：

  Methods and compositions employing 4-aminophenylacetic acid compounds

  摘要：

  本发明提供了包含4-APAA化合物的组合物以及治疗涉及消化系统和/或黏膜组织炎症的疾病的方法，例如炎性肠病。本发明的方法和组合物还包括4-APAA化合物和5-ASA化合物的组合治疗此类疾病。

  公开号：

  US20070060552A1

文献信息

• Nitrogen bridgehead compounds. Part 18. New antiallergic 4H-pyrido[1,2-a]pyrimidin-4-ones. Part I
  作者：Istvan Hermecz、Tibor Breining、Zoltan Meszaros、Agnes Horvath、Lelle Vasvari-Debreczy、Franz Dessy、Christine DeVos、Ludovic Rodriquez

  DOI：10.1021/jm00352a008

  日期：1982.10

  A new type of antiallergic agent, 9-hydrazono-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-ones, was synthesized and evaluated for inhibitory effects in the rat reagenic passive cutaneous anaphylaxis (PCA) screen. Several racemic 6-methyl derivatives were found to be more potent than disodium chromoglycate intravenously and some were also active orally. Structure-activity relationships are discussed

  合成了一种新型的抗过敏药9-肼基-6,7,8,9-四氢-4H-吡啶并[1,2-a]嘧啶-4-酮，并评估了其对大鼠自发性被动皮肤的抑制作用。过敏反应（PCA）屏幕。已发现几种消旋的6-甲基衍生物在静脉内比色甘氨酸二钠更有效，有些还具有口服活性。讨论了构效关系。在具有6S和6R绝对构型的对映异构体之间的6-甲基系列中观察到高立体特异性，前者更具活性。化合物17，（+）-6（S）-甲基-9-（苯肼基）-4-氧代-4H-吡啶并[1,2-a]嘧啶-3-羧酸[Chinoin-1045; [UCB L140]，ED50值为1.0 mumol / kg po，目前正在临床研究中。
• Carbon black reacted with diazonium salts and products
  申请人：CABOT CORPORATION

  公开号：EP1225205A2

  公开（公告）日：2002-07-24

  The present invention is directed to carbon black products having an organic group attached to the carbon black and processes for their preparation. In one process at least one diazonium salt reacts with a carbon black in a protic reaction medium. Uses of such carbon black products in plastic compositions, rubber compositions, paper compositions, and textile compositions are also disclosed.

  本发明涉及炭黑上附有有机基团的炭黑产品及其制备工艺。在一种工艺中，至少有一种重氮盐与炭黑在质子反应介质中发生反应。本发明还公开了此类炭黑产品在塑料组合物、橡胶组合物、纸张组合物和纺织组合物中的用途。
• Reaction of carbon black with diazonium salts, resultant carbon black products and their uses
  申请人：——

  公开号：US20030095914A1

  公开（公告）日：2003-05-22

  Processes for preparing a carbon black product having an organic group attached to the carbon black. In one process at least one diazonium salt reacts with a carbon black in the absence of an externally applied electric current sufficient to reduce the diazonium salt. In another process at least one diazonium salt reacts with a carbon black in a protic reaction medium. Carbon black products which may be prepared according to process of the invention are described as well as uses of such carbon black products in plastic compositions, rubber compositions, paper compositions, and textile compositions.

  制备炭黑产品的工艺，炭黑上附有有机基团。在一种工艺中，至少一种重氮盐在没有足以还原重氮盐的外加电流的情况下与炭黑反应。在另一种工艺中，至少一种重氮盐与炭黑在质子反应介质中发生反应。描述了根据本发明工艺可制备的炭黑产品，以及此类炭黑产品在塑料组合物、橡胶组合物、纸张组合物和纺织组合物中的用途。
• Diazonium−Protein Adducts for Graphite Electrode Microarrays Modification:  Direct and Addressed Electrochemical Immobilization
  作者：Benjamin P. Corgier、Christophe A. Marquette、Loïc J. Blum

  DOI：10.1021/ja056946w

  日期：2005.12.1

  Diazonium cation electrodeposition was investigated for the direct and electro-addressed immobilization of proteins. For the first time, this reaction was triggered directly onto diazonium-modified proteins. Screen-printed (SP) graphite electrode microarrays were studied as active support for this immobilization. A 10-microelectrode (eight working electrodes, 0.2 mm(2) each; one reference; and one auxiliary) setup was used to study the addressing possibilities of the method. These electrode microarrays were shown to be able to covalently graft diazonium cations through electrochemical reduction. Cyclic voltammetry and X-ray photoelectron spectroscopy were used to characterize the electrochemical grafting onto our SP graphite surface and suggested that a diazonium monolayer was deposited. Rabbit and human immunoglobulins (IgGs) were then chemically coupled to an aniline derivative (4-carboxymethylaniline), followed by diazotation to form art aryl diazonium function available for the electrodeposition. These modified proteins were both successfully electro-addressed at the surface of the graphite electrodes without crosstalk or interference. The immuno-biochip obtained using this novel approach enabled the specific detection of anti-rabbit IgG antibodies with a detection limit of 50 fmol of protein. A promising strategy to immobilize markedly different biological entities was then presented, providing an excellent spatial specificity of the electro-addressing.
• HERMECZ, I.;BREINING, T.;MESZAROS, Z.;HORVATH, A.;VASVARI-DEBRECZY, L.;DE+, J. MED. CHEM., 1982, 25, N 10, 1140-1145
  作者：HERMECZ, I.、BREINING, T.、MESZAROS, Z.、HORVATH, A.、VASVARI-DEBRECZY, L.、DE+

  DOI：——

  日期：——