diphenyl-4,4'-bis-(-salicylic acid) | 494-77-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl-4,4'-bis-(-salicylic acid)
• 英文别名: Chrysamine G；6,6'-dihydroxy-3,3'-biphenyl-4,4'-diyl-bis-azo-di-benzoic acid；6,6'-Dihydroxy-3,3'-biphenyl-4,4'-diylbisazo-di-benzoesaeure；4.4'-Bis-(4-hydroxy-3-carboxy-phenylazo)-biphenyl；Chrysamin G；Diphenyl-4.4'-bis-[(azo 5)-salicylsaeure]；4,4'-bis-(3-carboxy-4-hydroxy-phenylazo)-biphenyl
• CAS: 494-77-9
• 化学式: C₂₆H₁₈N₄O₆
• 分子量: 482.452
• InChiKey: XFFSCOOTVXBLCK-QAVVBOBSSA-N

物化性质

• 沸点：
  814.2±65.0 °C(Predicted)
• 密度：
  1.42±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.99
• 重原子数：
  36.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  164.5
• 氢给体数：
  4.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  diphenyl-4,4'-bis-(-salicylic acid) 在 盐酸 、 sodium hypochlorite 作用下， 生成 2,4,5-trichloro-3,6-dioxo-cyclohexa-1,4-dienecarboxylic acid
  参考文献：
  名称：

  Seyewetz; Chaix, Bulletin de la Societe Chimique de France, 1927, vol. <4>41, p. 347

  摘要：

  DOI：
• 作为产物：
  描述：

  联苯胺 生成 diphenyl-4,4'-bis-(-salicylic acid)
  参考文献：
  名称：

  DE31658

  摘要：

  公开号：

文献信息

• HETEROCYCLIC INDENE DERIVATIVES AND THEIR RADIOISOTOPE LABELED COMPOUNDS FOR IMAGING BETA-AMYLOID DEPOSITION
  申请人：JEONG Jae Min

  公开号：US20080299041A1

  公开（公告）日：2008-12-04

  The invention is directed to heterocyclic indene derivatives useful for β-amyloid plaque imaging, their radiolabeled compounds and their preparation methods. The compounds of the invention are easily labeled with radioisotopes and have high affinities to β-amyloid depositions, thus they facilitate diagnosis of Alzheimer's disease by imaging the distribution of β-amyloid depositions.

  本发明涉及杂环吲哚衍生物，其可用于β-淀粉样斑块成像，其放射性标记化合物及其制备方法。本发明的化合物易于标记放射性同位素，并具有高亲和力与β-淀粉样沉积物，因此它们通过成像β-淀粉样沉积物的分布，促进阿尔茨海默病的诊断。
• MOLECULAR PROBES FOR DETECTING LIPID COMPOSITION
  申请人：Case Western Reserve University

  公开号：US20140079635A1

  公开（公告）日：2014-03-20

  A method of detecting myelin in a subject includes administering to the subject a molecular probe that includes a fluorescent trans stilbene derivative and detecting the amount or distribution of the molecular probe in a tissue of interest of the subject.

  一种检测受试者髓鞘的方法，包括向受试者施加一种分子探针，该探针包括一种荧光转-史蒂本衍生物，并检测受试者感兴趣的组织中分子探针的数量或分布。
• Azocompounds for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
  申请人：UNIVERSITY OF PITTSBURGH

  公开号：EP1110945A2

  公开（公告）日：2001-06-27

  Amyloid binding compounds which are derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing Chrysamine G and derivatives thereof and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.

  本文描述了作为金黄胺 G 衍生物的淀粉样蛋白结合化合物、含有此类化合物的药物组合物以及使用此类化合物鉴定体内阿尔茨海默氏症大脑和诊断以淀粉样变性为特征的其他病理状况（如唐氏综合症）的方法。此外，还描述了含有金黄胺 G 及其衍生物的药物组合物，以及使用此类组合物在淀粉样变性相关病症中防止细胞变性和淀粉样诱导毒性的方法。还介绍了使用金黄胺 G 衍生物染色或检测活检或死后组织中淀粉样沉积物的方法。还介绍了使用金黄胺 G 衍生物量化活检组织和死后组织匀浆中淀粉样蛋白沉积的方法。
• Heterocyclic molecules for biomedical imaging and therapeutic applications
  申请人：Washington University

  公开号：US10335504B2

  公开（公告）日：2019-07-02

  Probes which target diffuse and fibrillar forms of amyloid beta (Aβ) are described. These probes demonstrate high initial brain penetration and facile clearance from non-targeted regions. The agents can be used to image amyloid quantitatively for monitoring efficacy of Aβ-modifying therapeutics and assist in premortem diagnosis of Alzheimer's disease (AD). Disclosed probes can bind Aβ aggregates of preformed Aβ1-42 fibrils in vitro and can be used to image fibrillar and diffuse plaques ex vivo in brain sections. Disclosed probes can be used to determine Aβ burden in early stages of AD. These probes can be used for multimodality imaging of Aβ. F-AI-187 (1 μM) can detect Aβ plaques in brain sections of APP/PS1 mice. F-AI-187 (10 μM) can detect Aβ plaques in the frontal lobe in a brain section of a patient with confirmed AD. Some probes can be used for fluorescence imaging of plaque.

  本文介绍了针对淀粉样β（Aβ）弥散和纤维形式的探针。这些探针显示出较高的初始脑穿透性，并能从非靶向区域轻松清除。这些制剂可用于对淀粉样蛋白进行定量成像，以监测 Aβ 改性疗法的疗效，并有助于阿尔茨海默病（AD）的死前诊断。所公开的探针可在体外结合预形成的 Aβ1-42 纤维的 Aβ 聚集体，并可用于在体外对脑切片中的纤维斑块和弥漫斑块进行成像。所公开的探针可用于确定 AD 早期阶段的 Aβ 负担。这些探针可用于 Aβ 的多模态成像。F-AI-187（1 μM）可检测APP/PS1小鼠脑切片中的Aβ斑块。F-AI-187（10 μM）可检测确诊为注意力缺失症患者大脑切片中额叶的 Aβ 斑块。有些探针可用于斑块的荧光成像。
• Methods of preparing ophthalmic formulations and uses of same
  申请人：Cognoptix, Inc.

  公开号：US10350309B2

  公开（公告）日：2019-07-16

  The present invention relates to a process for preparing an ointment comprising subjecting a mixture of a fluorescent molecular rotor compound, mineral oil, and grinding media to ball milling agitation and combining this mixture with a hydrophobic vehicle for an ointment. The invention also relates to an ophthalmic formulation comprising a pharmaceutically acceptable carrier and a compound of the following structural Formula (I), or a pharmaceutically acceptable salt thereof: Values and preferred values of the variables in structural Formula (I) are described herein.

  本发明涉及一种制备软膏的工艺，包括将荧光分子转子化合物、矿物油和研磨介质的混合物进行球磨搅拌，并将该混合物与软膏的疏水性载体结合。本发明还涉及一种眼科制剂，该制剂包含一种药学上可接受的载体和一种结构式（I）如下的化合物或其药学上可接受的盐： 结构式（I）中各变量的值和优选值在此描述。