N-dodecyl-ethane-1,2-diamine | 35902-68-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-dodecyl-ethane-1,2-diamine
• 英文别名: N-dodecylethylenediamine；N'-dodecylethane-1,2-diamine
• CAS: 35902-68-2
• 化学式: C₁₄H₃₂N₂
• 分子量: 228.421
• InChiKey: QCENGKPIBJNODL-UHFFFAOYSA-N

物化性质

• 熔点：
  136-140 °C
• 沸点：
  130-132 °C(Press: 12 Torr)
• 密度：
  0.839±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-dodecyl-ethane-1,2-diamine 在 溶剂黄146 作用下， 以 正己烷 为溶剂， 反应 46.0h， 生成 1,3-didodecyl-4,5-dihydro-2-methyl-1H-imidazolium iodide
  参考文献：
  名称：

  新型手性和非手性长烷基链官能化咪唑啉离子液体的热化学和结构研究

  摘要：

  除了多功能的离子液体 (IL) 类别之外，本文还报道了一系列全新的基于咪唑啉的离子液体，具有手性和重要的热特性，例如多晶型、玻璃化转变和塑性结晶行为。一种用于长制备一种有效的和一般方法Ñ，Ñ '与任一烷基链取代的化合物饱和的（多个）或手性（C）环己基（CYC 6） -取代的咪唑鎓（IM）的主链，即，[C 12 Ç 12 RsIm][A] (A = Br – , [BF 4 ] - , [ClO 4 ] - , [PF 6 ] -; R = H, Me, i Pr) 和 [C 12 C 12 cIm-cyC 6 ][A] (A = Br – , I – , [I 3 ] - , [BF 4 ] - , [ClO 4 ] - , [PF 6 ] - , [SbF 6 ] - , [BPh 4 ] - ), 并通过热化学方法 (DSC, TGA)、X 射线小角度衍射 (SAXS) 研究了新化合物，单晶

  DOI：

  10.1021/acs.cgd.1c00734
• 作为产物：
  描述：

  十二烷醇 在 吡啶 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 N-dodecyl-ethane-1,2-diamine
  参考文献：
  名称：

  Diamine derivative anti-Trichomonas vaginalis and anti-Tritrichomonas foetus activities by effect on polyamine metabolism

  摘要：

  Human and bovine trichomoniasis are sexually transmitted diseases (STD) caused by Trichomonas vaginalis and Tritrichomonas foetus, respectively. Human trichomoniasis is the most common non-viral STD in the world and bovine trichomoniasis causes significant economic losses to breeders. Considering the significant impact of the infections caused by these protozoa and the treatment failures, the search for new therapeutic alternatives becomes crucial. In this study the effect of diamines and amino alcohols in the in vitro viability of trichomonads was evaluated. Screening demonstrated the high activity of diamine 4 against these protozoa. Although cytotoxicity against HMVII cell line and slight hemolysis were observed in vitro, the compound showed no toxic effect on the Galleria mellonella in vivo model. Importantly, diamine 4 was active against both trichomonads species at 6 h and 24 h of incubation, and these effects was reverted by putrescine, a polyamine, suggesting competition for the same metabolic pathway. These findings indicate that the mechanism of action of diamine 4 is through the polyamine metabolism, a pathway distinct from that presented by metronidazole, the drug usually used to treat trichomoniasis and to which resistance is widely reported. These data demonstrate the importance of diamines as potential novel candidates as anti-T. vaginalis and anti-T. foetus agents.

  DOI：

  10.1016/j.biopha.2017.09.007

文献信息

• Formation of ionic liquids of divalent metal complexes comprising N‑alkylethylenediamines and the solvation of the nickel(II) complexes
  作者：Haruka Yasuda、Chisayo Nakayama、Masayasu Iida

  DOI：10.1016/j.molliq.2018.07.124

  日期：2018.11

  A series of divalent N‑alkylethylenediamine (alkyl‑en) metal(II) (alkyl = hexyl, 2‑ethylhexyl, octyl, dodecyl; metal = Ni, Cu, and Zn) complexes was prepared and their phase behavior was studied using differential scanning calorimetry. This kind of metal complexes is very useful for systematically investigating the relationship between phase behavior and molecular structures. It was found that several

  制备了一系列二价N-烷基乙二胺（烷基）金属（II）（烷基=己基，2-乙基己基，辛基，十二烷基;金属= Ni，Cu和Zn）配合物，并使用差分扫描研究了它们的相行为量热法。这种金属络合物对于系统地研究相行为与分子结构之间的关系非常有用。发现尽管存在二价阳离子，但锌（II）和镍（II）络合物中的几种仍形成室温离子液体（RTIL）。 尽管基于金属（II）配合物的离子液体的固-液转变温度通常高于更常见的单价离子液体（IL）的温度，但它们取决于金属（II）离子的性质和组合，烷基链和抗衡阴离子。锌（II）配合物与弱配位的双（氟磺酰基）酰胺（FSA）或双（三氟甲磺酰基）酰胺（Tf 2 N）阴离子结合使用，其熔点明显较低，这归因于锌（II）离子之间的距离较长以及与NO 3中相应距离相比形成四面体双（烷基-en）锌（II）络合物的抗衡阴离子和三氟乙酸盐（TFA）配合物。熔点与锌（II）配合物分子结构的相关性与烷基银（I）配合物的相似。与Tf
• Metallomicelles of palladium(II) complexes as efficient catalysts for the Suzuki-Miyaura reaction in neat water
  作者：Yan Liu、Xiaowei Ma、Jianwei Xie、Ping Liu、Bin Dai、Ren He

  DOI：10.1002/aoc.3021

  日期：2013.8

  Metallomicelles of palladium(II) complex 4 are found to be an efficient catalyst for Suzuki–Miyaura reactions of aryl bromides substituted with a long alkyl chain and arylboronic acids at 80 °C in neat water. The reactions proceed smoothly to generate the corresponding biaryl compounds in moderate to excellent yields. Various biphenyl derivatives were successfully obtained by complex 4 catalysis of the Suzuki–Miyaura

  钯（II）配合物4的金属硅化物是纯水中80℃下被长烷基链取代的芳基溴化物和芳基硼​​酸的Suzuki-Miyaura反应的有效催化剂。反应平稳进行，以中等至优异的产率产生相应的联芳基化合物。在纯净水中不存在任何表面活性剂的情况下，通过Suzuki-Miyaura反应的复合物4催化成功地获得了各种联苯衍生物。版权所有©2013 John Wiley＆Sons，Ltd.
• BIO-NANO POWER CELLS AND THEIR USES
  申请人：Long Nathan R.

  公开号：US20130330293A1

  公开（公告）日：2013-12-12

  The present invention concerns bio-nano power cells and methods of their manufacture and use. More particularly, the present invention relates to the preparation of bio-nano power cells that are biocompatible and capable of producing flash, intermittent, or continuous power by electrolyzing compounds in biological systems.

  这项发明涉及生物纳米电池及其制造和使用方法。更具体地，这项发明涉及制备生物纳米电池，这些电池具有生物相容性，并能够通过在生物系统中电解化合物来产生闪光、间歇或持续电力。
• ANIONIC-CATIONIC-NONIONIC SURFACTANT,PRODUCTION AND USE THEREOF
  申请人：CHINA PETROLEUM & CHEMICAL CORPORATION

  公开号：US20170313928A1

  公开（公告）日：2017-11-02

  This invention relates to an anionic-cationic-nonionic surfactant as substantially represented by the formula (I), production and use thereof in tertiary oil recovery. The anionic-cationic-nonionic surfactant of this invention exhibits significantly improved interfacial activity and stability as compared with the prior art. With the present anionic-cationic-nonionic surfactant, a flooding fluid composition for tertiary oil recovery with improved oil displacement efficiency and oil washing capability as compared with the prior art could be produced. In the formula (I), each group is as defined in the specification.

  这项发明涉及一种阴离子-阳离子-非离子表面活性剂，其大致由式(I)所代表，以及该表面活性剂在三次采油中的生产和使用。该发明的阴离子-阳离子-非离子表面活性剂与现有技术相比具有明显改善的界面活性和稳定性。采用这种阴离子-阳离子-非离子表面活性剂，可以制备出用于三次采油的注水液组成物，其具有比现有技术更高的油位移效率和油洗能力。在式(I)中，每个基团如规范中所定义。
• Process of preparation of heterocyclic compounds employing acetylene ethers
  申请人：ORGANON

  公开号：US02813862A1

  公开（公告）日：1957-11-19

  The invention comprises compounds of the formula <;FORM:0785373/IV (a)/1>; wherein R is a -(CH2)6- or <;FORM:0785373/IV (a)/2>; group and R2 is hydrogen, alkyl, aryl or aralkyl. It comprises also a process for the preparation of compounds of the formula <;FORM:0785373/IV (a)/3>; wherein X is O, S, NH or NR3 (R3 is an alkyl, aryl or aralkyl group), by reacting a compound of the formula R1OC­C-R2, wherein R1 is an alkyl group, with a compound of the formula H2N-R-XH. The reaction is suitably carried out by allowing an alkoxyacetylene, such as an ethoxyacetylene compound, to react with an aminoalcohol, a diamine or a mercaptoamine. Examples describe the preparation according to the above process of (1) 2-methyl-oxazoline; (2) 2 : 4-dimethyl-oxazoline; (3) 2-methylimidazoline; (4) 2-methylbenzimidazole; (5) 2-methylthiazoline; (6) 2-methyl-1-dodecylimidazoline-2; (7) 2-propyl-imidazoline-2; (8) 2-benzylimidazoline-2; (9) 2-methyl- D 2-dihydro-oxazine - 1 : 3; (10) 2 - methyl - 3 : 4 : 5 : 6 - tetrahydropyrimidine; (11) 2-methyl-4 : 5-benzooxazine-1 : 3; (12) 2-methyl-5 : 6-dihydro-1 : 3-thiazine; (13) 2-(1-naphthylmethyl)-2-imidazoline; (14) 2-heptadecyl-2-imidazoline; (15) 2-methyl - 4 : 5 : 6 : 7 - tetrahydro - 1 : 3 - diazepine and (16) 2-methyl-4 : 5 : 6 : 7 : 8 : 9-hexahydro-1 : 3-oxazonine.

  这项发明包括以下公式的化合物：<;FORM:0785373/IV (a)/1>;其中R是一个-(CH2)6-或<;FORM:0785373/IV (a)/2>;基团，R2是氢、烷基、芳基或芳基烷基。它还包括一种制备以下公式的化合物的方法：<;FORM:0785373/IV (a)/3>;其中X是O、S、NH或NR3（R3是烷基、芳基或芳基烷基），通过将公式R1OC­C-R2的化合物（其中R1是烷基）与公式H2N-R-XH的化合物反应。反应通常通过允许烷氧基乙炔，如乙氧基乙炔化合物，与氨醇、二胺或巯胺反应来进行。示例描述了根据上述过程制备的化合物（1）2-甲基噁唑烷；（2）2 : 4-二甲基噁唑烷；（3）2-甲基咪唑烷；（4）2-甲基苯并咪唑；（5）2-甲基噻唑烷；（6）2-甲基-1-十二烷基咪唑-2；（7）2-丙基咪唑-2；（8）2-苄基咪唑-2；（9）2-甲基- D 2-二氢噁啉 - 1 : 3；（10）2-甲基-3 : 4 : 5 : 6-四氢嘧啶；（11）2-甲基-4 : 5-苯噁啉-1 : 3；（12）2-甲基-5 : 6-二氢-1 : 3-噻嗪；（13）2-(1-萘甲基)-2-咪唑烷；（14）2-庚十七烷基-2-咪唑烷；（15）2-甲基-4 : 5 : 6 : 7-四氢-1 : 3-二氮杂环己烷和（16）2-甲基-4 : 5 : 6 : 7 : 8 : 9-六氢-1 : 3-噁唑烷。