N,N'-(diphenyl)-1,3-diaminopropane dihydrochloride | 15179-78-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-(diphenyl)-1,3-diaminopropane dihydrochloride
• 英文别名: N,N'-diphenyl-1,3-propanediamine dihydrochloride；N,N'-diphenyl-propanediyldiamine; dihydrochloride；N,N'-Diphenyl-propandiyldiamin; Dihydrochlorid；N,N'-diphenylpropane-1,3-diamine;hydrochloride
• CAS: 15179-78-9
• 化学式: C₁₅H₁₈N₂*2ClH
• 分子量: 299.243
• InChiKey: GFRLDEIGQQZLBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.02
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  24.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-(diphenyl)-1,3-diaminopropane dihydrochloride 、 对甲苯磺酰氯 在 sodium hydroxide 作用下， 生成 N,N'-propanediyl-bis-toluene-4-sulfonanilide
  参考文献：
  名称：

  Synthesis of Disecondary Amines; N,N'-Diphenyl-α, ω-Diaminoalkanes

  摘要：

  DOI：

  10.1021/jo50001a004
• 作为产物：
  描述：

  丙烷,1,3-二叠氮- 、 二氯苯酚溴酯 以 甲苯 为溶剂， 反应 12.0h， 以74%的产率得到N,N'-(diphenyl)-1,3-diaminopropane dihydrochloride
  参考文献：
  名称：

  N,N'-取代对称二胺的有效合成

  摘要：

  摘要 N,N'-取代的对称二胺可以通过一锅法从二叠氮烷和二氯硼烷中以高收率轻松制备。这种方法已扩展到thermine的合成，一种从嗜热栖热菌中分离的四胺。

  DOI：

  10.1080/00397919208019266

文献信息

• Chelate-Controlled Synthesis of Racemic <i>a</i><i>nsa</i>-Zirconocenes
  作者：Matthew D. LoCoco、Xingwang Zhang、Richard F. Jordan

  DOI：10.1021/ja046629+

  日期：2004.11.1

  The reaction of ZrPhN(CH2)(3)NPh}Cl-2(THF)(2) (5) with lithium ansa-bis-indenyl reagents Li-2[XBI]-(Et2O) (XBI = (1-indenyl)(2)SiMe2 (SBI, 7a), (2-methyl-1-indenyl)(2)SiMe2 (MSBI, 7b), (2-methyl-4,5-benz-1-indenyl)(2)SiMe2 (MBSBI, 7c), (2-methyl-4-phenyl-1-indenyl)(2)SiMe2 (MPSBI, 7d), and 1,2-(1-indenyl)(2)ethane (EBI, 7e)) affords rac-(XBI)ZrPhN(CH2)(3)NPh} (8a-e) in high yield. The meso isomers were not detected by H-1 NMR. X-ray crystallographic studies show that the ZrPhN(CH2)(3)NPh) rings in 5, 8a, 8c, and (C5H5)(2)-ZrPhN(CH2)(3)NPh} (10) adopt twist conformations that position the N-Ph groups on opposite sides of the N-Zr-N plane. This conformation complements the metallocene structures of rac-8a-e but would destabilize the corresponding meso isomers. It is proposed that the ZrPhN(CH2)(3)NPh} ring adopts a similar twist conformation in the stereodetermining transition state for addition of the second indenyl ring in these reactions, which leads to a preference for rac products. The results of metallocene syntheses from other Zr amide precursors support this proposal. 8a-e are converted to the corresponding rac-(XBI)ZrCl2 complexes (9a-e) by reaction with HCl.
• A CYANINE-BASED PROBE\TAG-PEPTIDE PAIR FOR FLUORESCENCE PROTEIN IMAGING AND FLUORESCENCE PROTEIN IMAGING METHODS
  申请人：BATTELLE MEMORIAL INSTITUTE

  公开号：EP2152810A1

  公开（公告）日：2010-02-17
• [EN] A CYANINE-BASED PROBE\TAG-PEPTIDE PAIR FOR FLUORESCENCE PROTEIN IMAGING AND FLUORESCENCE PROTEIN IMAGING METHODS<br/>[FR] SONDE À BASE DE CYANINE IMAGERIE DE PROTÉINE DE FLUORESCENCE ET PROCÉDÉS D'IMAGERIE DE PROTÉINE DE FLUORESCENCE
  申请人：BATTELLE MEMORIAL INSTITUTE

  公开号：WO2008127768A1

  公开（公告）日：2008-10-23

  [EN] A molecular probe comprises two arsenic atoms and at least one cyanine based moiety. A method of producing a molecular probe includes providing a molecule having a first formula, treating the molecule with HgOAc, and subsequently transmetallizing with AsCI₃. The As is liganded to ethanedithiol to produce a probe having a second formula. A method of labeling a peptide includes providing a peptide comprising a tag sequence and contacting the peptide with a biarsenical molecular probe. A complex is formed comprising the tag sequence and the molecular probe. A method of studying a peptide includes providing a mixture containing a peptide comprising a peptide tag sequence, adding a biarsenical probe to the mixture, and monitoring the fluorescence of the mixture.
  [FR] L'invention concerne une sonde moléculaire qui comprend deux atomes d'arsenic et au moins une fraction basée sur la cyanine. Un procédé de production de sonde moléculaire consiste à produire une molécule possédant une première formule, à traiter la molécule avec du HgOAc, puis à la transmétalliser avec de l'AsCI₃. L'As est lié à de l'éthanedithiol afin de produire une sonde possédant une seconde formule. Un procédé d'étiquetage d'un peptide consiste à fournir une séquence d'étiquette et à mettre en contact le peptide avec une sonde moléculaire biarsénicale. Un complexe comprenant la séquence d'étiquette et la sonde moléculaire est formé. L'invention concerne également un procédé d'anaylse d'un peptide qui consiste à produire un mélange contenant un peptide à séquence d'étiquette peptidique, à ajouter une sonde biarsénicale au mélange, et à surveiller la fluorescence du mélange.
• An Efficient Synthesis of N,N'-Substituted Symmetrical Diamines
  作者：Michel Vaultier、Bertrand Carboni、Pilar Martinez-Fresneda

  DOI：10.1080/00397919208019266

  日期：1992.3

  Abstract N,N'-substituted symmetrical diamines are readily prepared in high yields in a one-pot procedure from diazidoalcanes and dichloroboranes. This approach has been extended to the synthesis of thermine, a tetramine isolated from Thermus Thermophilus.

  摘要 N,N'-取代的对称二胺可以通过一锅法从二叠氮烷和二氯硼烷中以高收率轻松制备。这种方法已扩展到thermine的合成，一种从嗜热栖热菌中分离的四胺。
• Synthesis of Disecondary Amines; N,N'-Diphenyl-α, ω-Diaminoalkanes
  作者：John H. Billman、Lyman R. Caswell

  DOI：10.1021/jo50001a004

  日期：1951.7