sodium dodecyl tris(oxyethylene) sulfate | 13150-00-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: sodium dodecyl tris(oxyethylene) sulfate
• 英文别名: Sodium Laureth Sulfate；sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate
• CAS: 13150-00-0
• 化学式: C₁₈H₃₇O₇S*Na
• 分子量: 420.543
• InChiKey: SXHLENDCVBIJFO-UHFFFAOYSA-M

物化性质

• 分解：
  When heated to decomposition it emits toxic fumes of /sulfur oxide and sodium oxide/.

计算性质

• 辛醇/水分配系数(LogP)：
  0.44
• 重原子数：
  27
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  7

ADMET

毒理性

• 人类毒性摘录

经口摄入中等毒性。

Moderately toxic by ingestion.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在大鼠中进行0.5%浓度持续2年的喂养实验，没有产生明显的解剖学、生化和显微病变。每周两次，将5%的水溶液涂抹于瑞士雌性小鼠的皮肤上，持续105周，未产生皮肤肿瘤。

FEEDING EXPERIMENTS IN RATS @ LEVELS OF 0.5% FOR 2 YR PRODUCED NO GROSS ANATOMICAL, BIOCHEM OR MICROSCOPIC LESIONS. TWICE WEEKLY APPLICATIONS FOR 105 WK OF 5% AQUEOUS SOLN TO SKIN OF SWISS FEMALE MICE PRODUCED NO SKIN TUMORS.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在大鼠中，急性口服LD50值范围为1-2克/千克；在90天喂养研究中，器官重量、血清尿素和总蛋白浓度在5000 ppm时增加。

IN RATS ACUTE ORAL LD50 VALUES RANGED FROM 1-2 G/KG; IN 90-DAY FEEDING STUDY, INCR IN ORGAN WT, SERUM UREA & TOTAL PROTEIN CONCN @ 5000 PPM.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

氮气泡在体外激活人血清补体的情况被研究。从四名健康志愿者（两名男性）获得的血清（有无红细胞）被暴露于来自一个特殊设计的气泡发生器的氮气泡中，暴露时间为1到30分钟，温度为37°C。对照组样本在37°C下孵育相同时间，但不暴露于氮气泡。通过放射免疫分析技术测量补体分裂产物C5a-des-Arg（C5a）的生成来确定补体固定的程度。在涉及红细胞的实验中，也测量了红细胞结合的C3d。暴露于氮气泡30分钟后，血清中C5a的浓度显著增加。暴露15分钟后，血清C5a浓度有非显著增加。在15分钟氮气泡暴露结束后，C5a浓度在长达60分钟内显著增加。红细胞的加入增加了补体激活的程度。氮气泡的暴露增加了红细胞/C3d结合的程度。结论是，血清补体的激活可能是减压病一些症状的原因，特别是发病率的个体内和个体间变异。在氮气诱导的补体激活过程中，C3d也会沉积在红细胞上。这表明，旁观者红细胞结合的C3d可能是体内补体激活的重要生物标志物。

The activation of human serum complement by nitrogen bubbles was studied in-vitro. Sera (with or without red blood cells) obtained from four healthy volunteers, two males, were exposed to nitrogen bubbles delivered from a specially designed bubbler for 1 to 30 minutes at 37 °C. Control samples were incubated at 37 °C for the same period but not exposed to nitrogen bubbles. The extent of complement fixation was determined by measuring formation of the fluid phase complement split product C5a-des-Arg (C5a) by a radio immunoassay technique. In the experiments involving erythrocytes, red cell bound C3d was also measured. The concentration of C5a was significantly increased in sera exposed to nitrogen bubbles for 30 minutes. Serum C5a concentration was nonsignificantly increased after 15 minutes exposure. C5a concentrations were significantly increased for up to 60 minutes after a 15 minute exposure to nitrogen bubbles ended. The presence of red blood cells increased the extent of complement activation. The extent of erythrocyte/C3d binding was increased by exposure to nitrogen bubbles. It was concluded that serum complement activation may be responsible for some of the symptoms of decompression sickness, especially the intra and interindividual variations in morbidity. C3d deposition also occurs on red blood cells during nitrogen induced complement activation. This suggests that bystander erythrocyte bound C3d may be an important biomarker for in-vivo complement activation.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性值

大鼠口服LD50 1820毫克/千克

LD50 Rat oral 1820 mg/kg

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 海关编码：
  3402110000

制备方法与用途

阴离子表面活性剂——十二烷基醚硫酸钠（AES, SLES），是一种性能优良的去污剂。其用量仅次于LAS，广泛应用于各类洗涤产品中。

AES 具有出色的去污、乳化、润湿和增溶能力，溶解性好且具有良好的增稠效果。它还表现出广谱配伍性和强抗硬水性，并具有较高的生物降解度，对皮肤和眼睛的刺激性较低。这种表面活性剂广泛用于液体洗涤剂，如餐洗液、洗发香波、泡沫浴液和洗手液。

此外，AES 还可应用于洗衣粉及重垢洗涤剂中。使用 AES 部分或全部替代 LAS 不仅可以减少磷酸盐的用量，还能降低总活性物含量。同时，在纺织印染、石油、皮革等行业中，AES 也可作为润滑剂助染剂、清洁剂、发泡剂和脱脂剂等。

反应信息

• 作为产物：
  描述：

  3-十二烷醇 在 氯磺酸 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.5h， 生成 sodium dodecyl tris(oxyethylene) sulfate
  参考文献：
  名称：

  N，N-二甲基-N-十二烷基聚氧乙烯胺基表面活性剂的合成及表面性质：氧化胺，甜菜碱和磺基甜菜碱

  摘要：

  已经合成了非离子-两性离子杂化表面活性剂，即N，N-二甲基-N-十二烷基聚氧乙烯（3）氧化胺，以及相应的甜菜碱和/或磺基甜菜碱。它们的分子结构通过电喷雾电离质谱和1 H核磁共振来表征。与结构上相关的常规氧化胺，甜菜碱和磺基甜菜碱相比，三种混合表面活性剂的临界胶束浓度比传统表面活性剂的临界胶束浓度小一个数量级。亲水性头基和疏水性尾部之间的聚氧乙烯链段使杂化表面活性剂的表面活性优于其结构相关的表面活性剂。

  DOI：

  10.1007/s11743-013-1540-7

文献信息

• 单分散九聚乙二醇十二烷基醇单醚及其硫酸盐的制备方法和应用
  申请人：武汉大学

  公开号：CN106316802A

  公开（公告）日：2017-01-11

  本发明公开了一种单分散九聚乙二醇十二烷基醇单醚及其硫酸盐的制备方法和应用，属于医药化工领域。从十二烷基醇出发，首先在碱的作用下通过与九聚乙二醇环硫酸酯的一次开环反应或通过与共含有九个乙二醇单元的多个寡聚乙二醇环硫酸酯的多次开环反应得到九聚乙二醇十二烷基醇单醚的硫酸盐；然后在硫酸的作用下水解得到九聚乙二醇十二烷基醇单醚。该方法可用于单分散聚乙二醇的长链烷基单醚及其硫酸盐的制备中。本发明以单一分子量聚乙二醇环硫酸酯为原料实现了六聚以上乙二醇的烷基醇单醚的高效合成，合成中没有用保护基，步骤简便，适于工业化生产，得到的产品相对于现有制备的聚桂醇具有明显的优势。
• Method and Device for the Sulfonation or Sulfation of Sulfonatable or Sulfatable Organic Substances and for Performing Faster, Strongly Exothermic Gas/Liquid Reactions
  申请人：Aigner Rudolf

  公开号：US20080306295A1

  公开（公告）日：2008-12-11

  A method and a device for the sulfonation or the sulfation of organic liquid raw materials with an S0 3 /air mixture and other reaction gases in order to perform rapid, highly exothermic gas-liquid reactions in conventional thin-layer falling-film reactors are disclosed. The introduction of the S0 3 /air mixture occurs through several feed locations, which are located within (along) the reaction tube or reaction tubes or in the annular gap of annular-gap falling-film reactors. High peak temperatures, undesirable byproducts, worsening of the color and local oversulfation or oversulfonation, which leads to side reactions, are largely avoided.

  本发明揭示了一种用S03/空气混合物和其他反应气体对有机液体原料进行磺化或硫酸化的方法和装置，以便在传统的薄层下降膜反应器中进行快速、高放热气液反应。S03/空气混合物的引入通过位于反应管或反应管内或环形间隙内的几个进料位置进行。大部分避免了高峰温度、不良副产品、颜色恶化和局部过磺化或过硫酸化，从而导致副反应。
• FORMULATION BASED ON MICRONIZED NATURAL CALCITE MINERAL AND MICRONIZED ZEOLITE AS AN ENHANCED PLANT BOOSTER AND MINERAL FERTILIZER
  申请人：Lelas Antonio

  公开号：US20110224080A1

  公开（公告）日：2011-09-15

  The present invention is related to a formulation based on (i) micronized natural calcite mineral (MC) of particles size from 500 nm to 5 μm, which contains variable amounts of calcite (CaCO 3 ), dolomite [CaMg (CO 3 ) 2 ], ankerite [Ca (Mg, Fe, Mn, Zn) (CO 3 ) 2 ], and quartz (SiO 2 ); (ii) micronized zeolite of particles size from 500 nm to 5 μm, of general formula (M n+ ) x/n [(AlO 2 ) x (SiO 2 ) y].mH 2 O (MZ) wherein Me=Na, K, Ca, Mg, Fe, Zn, Mn, Cu; whereas ratio of silicon to aluminum, y:x is between 1:1 to >10:1; whilst m is number of crystalline water molecules which can be from 0 to >20; and of (iii) one or more additives which, with components (i) and (ii), yiled in the final form of the formulation suitable for practical use: powder; wettable powder; concentrate for suspension; or granules; and/or which enhance basic biological actions of (i). The applications of the formulation result in the following effects: more effective stimulation of photosynthetic process in plants; more efficient stimulation of plant growth; enhanced viability of plants to stresses and diseases; improved absorption of nutrients from calcite mineral itself; improved absorption of nutrients applied through the soil; and especially, increased crop yields.
• FORMULATION BASED ON MICRONIZED NATURAL CALCITE MINERAL AS A PLANT BOOSTER AND MINERAL FERTILIZER
  申请人：Lelas Antonio

  公开号：US20110269627A1

  公开（公告）日：2011-11-03

  The present invention is related to a formulation based on micronized natural calcite mineral consisting of: A. mineral part which is characterized: (i) by the particle size with diameter smaller than 5 μm, where the distribution of particle size is such that minimum of 10% of particles are with diameter under 900 nm, with total surface of particles greater than 3.2 m 2 /g, and with total porous volume greater than 0.012 cm 3 /g, and by composition: (ii) CaCO 3 , MgCO 3 , FeCO 3 , MnCO 3 , ZnCO 3 and SiO 2 in mixtures where CaCO 3 is presented in amount from 10% to 99% of mineral part; and B. adjuvant selected from the group consisting of: wetting agent, drift-control agent at application by spraying, humic acid salt, amino-acids salts, complex of plant micro-nutrients, vitamin, plant hormone, nitrogen fertilizer, potassium salt, borate salt, molybdate salt, plant extract, chlorophyll, yeast extract, or mixture of these substances; where A. and B. form an aqueous suspension wherein percentage of A. and B. is lower than 5% by weight. The formulation from this invention is used as a plant booster and mineral fertilizer for stimulation of photosynthetic process in plants, stimulation of plants growth, reinforcement of plant resistance to physiological and anhydrous stress, reinforcement of resistance to different plant diseases, for improvement of nutrient absorption, for increasing crop yields, and for plant nutrition.
• US6706670B2
  申请人：——

  公开号：US6706670B2

  公开（公告）日：2004-03-16