6-diphenylphosphorylamino nicotinamide | 77837-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-diphenylphosphorylamino nicotinamide
• 英文别名: 6-(diphenylphosphorylamino)pyridine-3-carboxamide
• CAS: 77837-06-0
• 化学式: C₁₈H₁₆N₃O₂P
• 分子量: 337.318
• InChiKey: ZHRZGBRPTULMLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  85.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-Aminonicotinamide 、 二苯基次膦酰氯 在 吡啶 、 盐酸 作用下， 以 2-吡咯烷酮 、 乙醇 、 氯仿 为溶剂， 生成 6-diphenylphosphorylamino nicotinamide
  参考文献：
  名称：

  Treatment of psoriasis with nicotinamide analogues

  摘要：

  一种用于缓解牛皮癣症状的治疗方法被揭示，包括局部涂抹含有一种或多种烟酰胺类似物作为主要活性成分的乳霜、洗液、软膏或凝胶。治疗组合物可以包括上述活性成分中的单一成员，其总量占组合物重量的0.01至5%，或者其中的多种成分，其优选浓度范围为0.02至2%。已发现在人类中使用乳霜、软膏、洗液、水或凝胶局部涂抹治疗组合物可以实现从显著到完全缓解牛皮癣。

  公开号：

  US04258052A1

文献信息

• Method for generating mature β-like cells
  申请人：The University of Western Australia

  公开号：US10568913B2

  公开（公告）日：2020-02-25

  The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes.

  本发明涉及产生成熟的胰岛素分泌β样细胞的方法，包括以下步骤： (a)从细胞群中分离、纯化和/或富集β细胞祖细胞；(b)将β细胞祖细胞分化为未成熟的胰岛素分泌β样细胞；(c)将未成熟的胰岛素分泌β样细胞成熟为成熟的胰岛素分泌β样细胞，包括将未成熟的胰岛素分泌β样细胞暴露于钙三醇或其类似物。 更具体地说，本发明涉及产生用于治疗糖尿病的成熟胰岛素分泌β样细胞的方法。
• METHOD FOR GENERATING MATURE BETA-LIKE CELLS
  申请人：THE UNIVERSITY OF WESTERN AUSTRALIA

  公开号：US20160045554A1

  公开（公告）日：2016-02-18

  The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes.
• US4258052A
  申请人：——

  公开号：US4258052A

  公开（公告）日：1981-03-24
• [EN] METHOD FOR GENERATING MATURE &bgr;-LIKE CELLS<br/>[FR] PROCÉDÉ DE GÉNÉRATION DE CELLULES MATURES DE TYPE BÊTA
  申请人：UNIV WESTERN AUSTRALIA

  公开号：WO2014153620A1

  公开（公告）日：2014-10-02

  The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes.
• Treatment of psoriasis with nicotinamide analogues
  申请人：——

  公开号：US04258052A1

  公开（公告）日：1981-03-24

  A treatment to alleviate the symptoms of psoriasis consisting of topical application of a cream, lotion, ointment or gel containing as the principal active ingredient one or more nicotinamide analogues is disclosed. The therapeutic composition may include a single member of the above active ingredients present in a total amount of from 0.01 to 5 percent by weight of the total composition or a plurality thereof present in a preferred concentration range of from 0.02 to 2 percent by weight of the total composition. Topical application of the therapeutic composition in a cream, ointment, lotion, water or gel has been found to achieve from substantial to complete remissions of psoriasis in humans.

  一种用于缓解牛皮癣症状的治疗方法被揭示，包括局部涂抹含有一种或多种烟酰胺类似物作为主要活性成分的乳霜、洗液、软膏或凝胶。治疗组合物可以包括上述活性成分中的单一成员，其总量占组合物重量的0.01至5%，或者其中的多种成分，其优选浓度范围为0.02至2%。已发现在人类中使用乳霜、软膏、洗液、水或凝胶局部涂抹治疗组合物可以实现从显著到完全缓解牛皮癣。