6-(methylaminomethylidene)cyclohexa-2,4-dien-1-one | 107910-69-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 6-(methylaminomethylidene)cyclohexa-2,4-dien-1-one
• 英文别名: N-salicylidene methylamine；N-methyl-N-[2-hydroxybenzyliden]amine；2-[(E)-(methylimino)methyl]phenol；2-(N-methyl-iminomethyl)-phenol；2-hydroxybenzylidenemethylamine；salicyl aldehyde N-methylimine；o-(methyliminomethyl)phenol
• CAS: 107910-69-0
• 化学式: C₈H₉NO
• 分子量: 135.166
• InChiKey: XFDQQADEQRAUEK-RMKNXTFCSA-N

物化性质

• 沸点：
  236.6±23.0 °C(Predicted)
• 密度：
  1.01±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  10.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  32.59
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  6-(methylaminomethylidene)cyclohexa-2,4-dien-1-one 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 生成 2-羟基-N-甲基苄胺盐酸盐
  参考文献：
  名称：

  An Alternative Synthesis of a Potent GPIIb/IIIa Receptor Antagonist

  摘要：

  SB-214857的关键中间体是通过使用弗莱米盐对带有天冬氨酸侧链的对苯二酚进行氧化环化制备的。

  DOI：

  10.1055/s-1999-3094
• 作为产物：
  描述：

  邻甲基苄醇 、 甲胺 以 甲醇 为溶剂， 反应 1.0h， 生成 6-(methylaminomethylidene)cyclohexa-2,4-dien-1-one
  参考文献：
  名称：

  摘要：

  Study of the absorption and luminescence spectra of Schiff bases derived from o-(p-tolylsulfonylamino)benzaidehyde has shown : that these systems, like those derived from salicylaldehyde, are characterized by intramolecular proton transfer in the excited and ground electronic states. This process is responsible for the appearance at 77 K of fluorescence with an anomalous Stokes shift and formation of ketone structures. Unlike o-[alkyl(or aryl)iminomethyl]phenols, o-[alkyl(or aryl)iminomethyl]anilines do not give rise to acoplanarization of the ketone fragment, which could follow intramolecular proton transfer in the excited state and is responsible for fluorescence with an anomalous Stokes shift and formation of colored structures.

  DOI：

  10.1023/a:1020809814260

文献信息

• NOVEL ORGANIC HETEROCYCLIC COMPOUND AND LIGHT-EMITTING DEVICE COMPRISING SAME
  申请人：SFC CO., LTD.

  公开号：US20180072753A1

  公开（公告）日：2018-03-15

  The present invention relates to an organic light-emitting compound represented by [Chemical Formula A] and an organic light-emitting device. In Chemical Formula, A, X, Y, Z, and the substituents R 1 to R 8 , and R 11 to R 20 are as defined in the specification.

  本发明涉及一种由[化学公式A]表示的有机发光化合物以及一种有机发光器件。在化学公式中，A、X、Y、Z以及取代基R1至R8和R11至R20如说明书中所定义。
• [EN] PROTECTIVE GROUPS AND METHODS FOR PROTECTING BENZOXABOROLES OR OXABOROLES<br/>[FR] GROUPES PROTECTEURS ET PROCÉDÉS DE PROTECTION DE BENZOXABOROLES OU D'OXABOROLES
  申请人：UNIV OF THE SCIENCES

  公开号：WO2019173814A1

  公开（公告）日：2019-09-12

  The present invention relates in part protective groups that can be used to reversibly protect benzoxaboroles and/or oxaboroles and yield the corresponding protected complexes. The invention further relates to the use of these protective groups to protect benzoxaboroles and/or oxaboroles.

  本发明部分涉及可用于可逆保护苯并硼酮和/或氧硼酮并产生相应保护复合物的保护基。本发明还涉及使用这些保护基来保护苯并硼酮和/或氧硼酮。
• Novel Pyrimidine- And Triazine-Hepcidine Antagonists
  申请人：Dürrenberger Franz

  公开号：US20120202806A1

  公开（公告）日：2012-08-09

  The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).

  本发明涉及新的肝铁蛋白拮抗剂，包含它们的药物组合物以及将其用作药物的用途，特别是用于治疗铁代谢紊乱，如特别是铁缺乏病和贫血，特别是与慢性炎症性疾病相关的贫血（ACD：慢性疾病性贫血和AI：炎症性贫血）。
• Organometallic Complex, and Light-Emitting Element, Light-Emitting Device, and Electronic Device Using the Organometallic Complex
  申请人：Inoue Hideko

  公开号：US20080312437A1

  公开（公告）日：2008-12-18

  According to the present invention, a wider variation of organometallic complexes that can emit phosphorescence can be provided by applying, as a ligand, an organic compound from which a variety of derivatives can be easily synthesized. In particular, an organometallic complex having a sharp emission spectrum is provided. Further, an organometallic complex having high emission efficiency is provided. An organometallic complex represented by the general formula (G1) is provided. In the formula, Ar represents an aryl group, R represents an alkoxy group having 1 to 4 carbon atoms, and R 1 and R 2 individually represent either hydrogen or an alkyl group having 1 to 4 carbon atoms.

  根据本发明，通过应用一种作为配体的有机化合物，可以提供更广泛的能够发射磷光的有机金属配合物变体，从而可以轻松合成各种衍生物。特别地，提供了具有尖锐发射光谱的有机金属配合物。此外，提供了具有高发射效率的有机金属配合物。提供了由通式（G1）表示的有机金属配合物。在该式中，Ar代表芳基，R代表具有1至4个碳原子的烷氧基，R1和R2分别表示氢或具有1至4个碳原子的烷基。
• Organometallic Complex, Light-Emitting Element, Light-Emitting Device, and Electronic Device Including the Organometallic Complex
  申请人：Inoue Hideko

  公开号：US20120165523A1

  公开（公告）日：2012-06-28

  Provided is a novel organometallic complex which can be synthesized easily and emits phosphorescence, or a compound which emits red phosphorescence. The inventors focused on easy synthesis of an m-aminophenyl pyrazine derivative represented by the following general formula (G0), synthesized an organometallic complex having a structure in which the derivative is coordinated to a Group 9 or Group 10 metal ion, and further synthesized a useful substance which emits red phosphorescence.

  提供了一种新型的有机金属配合物，可以轻松合成并发射磷光，或者是发射红色磷光的化合物。发明者专注于易于合成的m-氨基苯基吡嗪衍生物，该衍生物由以下通用公式（G0）表示，合成了一种有机金属配合物，其中该衍生物与第9族或第10族金属离子配位，并进一步合成了一种发射红色磷光的有用物质。