1-methylethylamino-2-propylamine | 796038-34-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methylethylamino-2-propylamine
• 英文别名: 1-N-ethyl-1-N-methylpropane-1,2-diamine
• CAS: 796038-34-1
• 化学式: C₆H₁₆N₂
• 分子量: 116.206
• InChiKey: ZWAVQTLSMDPBHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methylethylamino-2-propylamine 、 5,5-二甲己烷2,4-二酮 在 sodium sulfate 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以91%的产率得到2,2-dimethyl-5-(1-methylethylamino-2-propylimino)-3-hexanone
  参考文献：
  名称：

  Metal complexes of tridentate beta-ketoiminates

  摘要：

  公开号：

  EP2065364B1

文献信息

• [EN] 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] DERIVES AMIDES DE L'ACIDE CARBOXYLIQUE DE 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE 3 ET COMPOSES ASSOCIES EN TANT QU'ANTAGONISTES DE RECEPTEUR DE B1 DE LA BRADYKININE POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：ELAN PHARM INC

  公开号：WO2004098589A1

  公开（公告）日：2004-11-18

  Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  公开的是化合物I和II的结构式，它们是激肽酶B1受体拮抗剂，适用于治疗哺乳动物中由激肽酶B1受体介导的疾病，或缓解与疾病状况相关的不良症状。其中某些化合物表现出增强的效力，并且预计还将表现出延长作用的特性。
• Novel compounds useful for bradykinin B1 receptor antagonism
  申请人：Ye Michael Xiaocong

  公开号：US20070032475A1

  公开（公告）日：2007-02-08

  Disclosed are compounds that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor.

  揭示了一种化合物，它们是布雷金肽B1受体拮抗剂，可用于治疗或缓解由布雷金肽B1受体介导的哺乳动物疾病，或与疾病状况相关的不良症状。
• Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
  申请人：Tung S. Jay

  公开号：US20050020659A1

  公开（公告）日：2005-01-27

  Disclosed are compounds that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明公开了一种布雷肯肽B1受体拮抗剂化合物，可用于治疗哺乳动物中由布雷肯肽B1受体介导的疾病或缓解与疾病状况相关的不良症状。其中某些化合物表现出增强的效力，并且预计也会表现出增强的作用持续时间。
• 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
  申请人：Tung S. Jay

  公开号：US20060281733A1

  公开（公告）日：2006-12-14

  Disclosed are compounds of formula I and II that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明公开了式I和式II的化合物，它们是缓激肽B1受体拮抗剂，可用于治疗哺乳动物中由缓激肽B1受体介导的疾病，或缓解与疾病条件相关的不良症状。其中某些化合物表现出增强的效力，预计也会表现出增强的持续时间。
• Grafted viscosity index improver
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0400867A1

  公开（公告）日：1990-12-05

  Oil soluble grafted ethylene-alpha-olefin copolymer useful as a viscosity modifier for oleaginous compositions comprising: (i) backbone copolymer of ethylene and at least one other alpha-olefin monomer, said copolymer comprising intramolecularly heterogeneous copolymer chains containing at least one crystallizable segment of methylene units and at least one low crystallinity ethylene-alpha-olefin copolymer segment, wherein said at least one crystallizable segment comprises at least about 10 weight percent of said copolymer chain and contains at least about 57 weight percent ethylene, wherein said low crystallinity segment contains not greater than about 53 weight percent ethylene, and wherein said copolymer has a molecular weight distribution characterized by at least one of a ratio of Mw/Mn of less than 2 and a ratio of Mz/M2 of less than 1.8, and wherein at least two portions of an individual intramolecularly heterogeneous chain, each portion comprising at least 5 weight percent of said chain, differ in composition from one another by at least 7 weight percent ethylene; having grafted on said backbone copolymer (ii) residue of ethylenically unsaturated grafting material; said grafted ethylenealpha-olefin copolymer having substantially the molecular weight distribution, i.e., within about 10 percent, of said copolymer of ethylene. The preferred grafting material is an ethylenically monounsaturated carboxylic acid material having 1 to 2 carboxylic acid groups or an anhydride group.

  可溶于油的接枝乙烯-α-烯烃共聚物，可用作含油组合物的粘度调节剂，其成分包括 (i) 乙烯和至少另一种α-烯烃单体的骨架共聚物，所述共聚物包括分子内异构共聚物链，其中至少含有一个亚甲基单元的可结晶段和至少一个低结晶度的乙烯-α-烯烃共聚物段、其中所述至少一个可结晶段占所述共聚物链的至少约 10 重量％，并含有至少约 57 重量％的乙烯，其中所述低结晶度段含有不大于约 53 重量％的乙烯，并且所述共聚物具有分子量分布，其特征为 Mw/Mn 比值小于 2 和 Mz/M2 比值小于 1 中的至少一种。8，且其中单个分子内异质链的至少两个部分（每个部分占所述链的至少 5 重量％）在组成上彼此相差至少 7 重量％的乙烯；在所述骨架共聚物上接枝有 (ii) 乙烯不饱和接枝材料的残留物；所述接枝的乙烯-α-烯烃共聚物的分子量分布与所述乙烯共聚物基本相同，即在约 10%以内。优选的接枝材料是具有 1 至 2 个羧酸基团或酸酐基团的乙烯单不饱和羧酸材料。