m-Chlorbenzyl-ethyl-ether | 68578-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: m-Chlorbenzyl-ethyl-ether
• 英文别名: ethyl-(3-chloro-benzyl)-ether；Aethyl-(3-chlor-benzyl)-aether；1-Chloro-3-(ethoxymethyl)benzene
• CAS: 68578-50-7
• 化学式: C₉H₁₁ClO
• 分子量: 170.639
• InChiKey: VGIVTNAZPRDSGW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 作用下， 生成 m-Chlorbenzyl-ethyl-ether
  参考文献：
  名称：

  DE166181

  摘要：

  公开号：

文献信息

• AMINO ACID COMPOUNDS AND METHODS OF USE
  申请人：Pliant Therapeutics, Inc.

  公开号：US20200109141A1

  公开（公告）日：2020-04-09

  The invention relates to compounds of formula (I): or a salt thereof, wherein R 1 , G, L 1 , L 2 , L 3 , and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, αvβ 1 integrin and αvβ 6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

  本发明涉及如下公式(I)的化合物： 或其盐，其中R1、G、L1、L2、L3和Y如本文所述。公式(I)的化合物及其药物组合物是αvβ1整合素和/或αvβ6整合素的一种或两种的抑制剂，用于治疗纤维化，如非酒精性脂肪肝炎（NASH）、特发性肺纤维化（IPF）和非特异性间质性肺炎（NSIP）。
• [EN] SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS<br/>[FR] INHIBITEURS SÉLECTIFS DE LA 17-BÊTA-HYDROXYSTÉROÏDE DÉSHYDROGÉNASE DE TYPE 1
  申请人：UNIV SAARLAND

  公开号：WO2012025638A1

  公开（公告）日：2012-03-01

  The invention relates to selective, non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitors their production and use, especially for the treatment and/or prophylaxis of hormone-related diseases.

  这项发明涉及选择性的、非类固醇17β-羟基类固醇脱氢酶1型（17β-HSD1）抑制剂的生产和使用，特别用于治疗和/或预防激素相关疾病。
• METHOD FOR PRODUCING 3-ARYLPROPIONAMIDE COMPOUND AND 3-ARYLPROPIONIC ACID ESTER COMPOUND
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20200165209A1

  公开（公告）日：2020-05-28

  The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine which is a production intermediate of the pyrimidine compound; a phenylethylamine compound useful as a pharmaceutical and agrochemical intermediate; and further a 3-arylpropionamide compound and a 3-arylpropionic acid ester compound useful as production intermediates of the phenylethylamine compound. The 3-arylpropionamide compound or the 3-arylpropionic acid ester compound can be efficiently and industrially produced in a single step by reacting a compound represented by formula (1) (wherein X represents a chlorine atom or a bromine atom; and Y represents an alkyl group optionally substituted with fluorine atom(s), a hydrogen atom, a fluorine atom, a cyano group, an alkylcarbonyl group, a dialkylamino group, or the like) with acrylamide or an acrylic acid ester in the presence of a metal catalyst and a reducing agent.

  本发明提供了一种工业生产方法：制备具有杀虫效果的嘧啶化合物；2-[4-(三氟甲基)苯基]乙胺，它是嘧啶化合物的生产中间体；一种作为药用和农药中间体有用的苯乙胺化合物；以及进一步的作为苯乙胺化合物的生产中间体有用的3-芳基丙酰胺化合物和3-芳基丙酸酯化合物。通过在金属催化剂和还原剂存在下，将由式(1)表示的化合物（其中X代表氯原子或溴原子；Y代表可选地取代氟原子、氢原子、氟原子、氰基、烷基羰基、二烷基氨基基团等的烷基基团）与丙烯酰胺或丙烯酸酯反应，可以高效地并且工业化地在一步中生产3-芳基丙酰胺化合物或3-芳基丙酸酯化合物。
• FREDERICAMYCIN DERIVATIVES
  申请人：Abel Ulrich

  公开号：US20120295856A1

  公开（公告）日：2012-11-22

  The invention relates to novel fredericamycin derivatives, to drugs containing said derivatives or the salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially cancer diseases.

  本发明涉及一种新型的fredericamycin衍生物，以及含有该衍生物或其盐的药物，以及利用该fredericamycin衍生物治疗疾病，特别是癌症疾病的用途。
• Method for producing 3-arylpropionamide compound and 3-arylpropionic acid ester compound
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US11028056B2

  公开（公告）日：2021-06-08

  The present invention provides a method for industrially producing: a pyrimidine compound having pest control efficacy; 2-[4-(trifluoromethyl)phenyl]ethylamine which is a production intermediate of the pyrimidine compound; a phenylethylamine compound useful as a pharmaceutical and agrochemical intermediate; and further a 3-arylpropionamide compound and a 3-arylpropionic acid ester compound useful as production intermediates of the phenylethylamine compound. The 3-arylpropionamide compound or the 3-arylpropionic acid ester compound can be efficiently and industrially produced in a single step by reacting a compound represented by formula (1) (wherein X represents a chlorine atom or a bromine atom; and Y represents an alkyl group optionally substituted with fluorine atom(s), a hydrogen atom, a fluorine atom, a cyano group, an alkylcarbonyl group, a dialkylamino group, or the like) with acrylamide or an acrylic acid ester in the presence of a metal catalyst and a reducing agent.

  本发明提供了一种工业化生产方法：一种具有害虫防治效果的嘧啶化合物；2-[4-(三氟甲基)苯基]乙胺，它是嘧啶化合物的生产中间体；一种苯基乙胺化合物，可用作医药和农用化学品中间体；以及一种3-芳基丙酰胺化合物和一种3-芳基丙酸酯化合物，可用作苯基乙胺化合物的生产中间体。3-arylpropionamide 化合物或 3-arylpropionic acid ester 化合物可通过式 (1) 所代表的化合物进行反应，在一个步骤中高效地工业化生产。 (其中 X 代表氯原子或溴原子；Y 代表任选被氟原子、氢原子、氟原子、氰基、烷基羰基、二烷基氨基等取代的烷基）与丙烯酰胺或丙烯酸酯在金属催化剂和还原剂存在下反应。