1-(2-methylbenzyl)thiourea | 16735-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-methylbenzyl)thiourea
• 英文别名: (2-methyl-benzyl)-thiourea；o-Tolubenzyl-thioharnstoff；(2-Methyl-benzyl)-thioharnstoff；(2-Methyl)benzylthiourea；(2-methylphenyl)methylthiourea
• CAS: 16735-74-3
• 化学式: C₉H₁₂N₂S
• 分子量: 180.274
• InChiKey: YDAKEVOYUPFWFX-UHFFFAOYSA-N

物化性质

• 沸点：
  320.1±45.0 °C(Predicted)
• 密度：
  1.155±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  70.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  potassium thioacyanate 、 alkaline earth salt of/the/ methylsulfuric acid 生成 1-(2-methylbenzyl)thiourea
  参考文献：
  名称：

  Strassmann, Chemische Berichte, 1888, vol. 21, p. 580

  摘要：

  DOI：

文献信息

• Novel quinazoline derivatives and methods of treatment related to the use thereof
  申请人：Sekiguchi Yoshinori

  公开号：US20070010671A1

  公开（公告）日：2007-01-11

  The present invention relates to novel compounds of Formula (1): which act as MCH receptor antagonists. These compositions are useful in pharmaceutical compositions whose use includes prophylaxis or treatment of improving memory function, sleeping and arousal, anxiety, depression, mood disorders, seizure, obesity, diabetes, appetite and eating disorders, cardiovascular disease, hypertension, dyslipidemia, myocardial infarction, binge eating disorders including bulimia, anorexia, mental disorders including manic depression, schizophrenia, delirium, dementia, stress, cognitive disorders, attention deficit disorder, substance abuse disorders and dyskinesias including Parkinson's disease, epilepsy, and addiction.

  本发明涉及一种新的化合物，其化学式为(1)，并作为MCH受体拮抗剂。这些化合物在制药组合物中的使用包括预防或治疗改善记忆功能、睡眠和觉醒、焦虑、抑郁、情绪障碍、癫痫、肥胖症、糖尿病、食欲和进食障碍、心血管疾病、高血压、血脂异常、心肌梗塞、暴食障碍（包括贪食症、厌食症）、精神障碍（包括躁郁症、精神分裂症、谵妄、痴呆）、压力、认知障碍、注意力缺陷障碍、物质滥用障碍和运动障碍（包括帕金森病、癫痫和成瘾）。
• COMPOSITIONS AND METHODS FOR THE TREATMENT OF MALARIA
  申请人：Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

  公开号：US20140296532A1

  公开（公告）日：2014-10-02

  The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided.

  本发明提供了氨基咪唑啉类抗疟疾药物。在某些实施例中，这些药物具有靶向疟疾天冬氨酸蛋白酶的功能特性，同时对人类β-淀粉样蛋白前体酶的活性较低。本发明还提供了使用这些药物的方法。
• INDAN DERIVATIVES
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP1085009A1

  公开（公告）日：2001-03-21

  Cardiac failure remedies containing as the active ingredient indan derivatives represented by general formula (I) or medicinally acceptable salts thereof, wherein R1 is hydrogen, nitro, cyano, amino, C1-C6 alkylcarbonylamino or the like; R2 and R3 are each independently C1-C6 alkyl or the like; R4 is hydroxyl or C1-C6 alkylcarbonyloxy, or alternatively R4 together with R5 represents a bond or oxygen; R5 is hydrogen, or alternatively R5 together with R4 represents a bond or oxygen; R6 is hydrogen, hydroxyl, NR7R8 or the like; n is an integer of 0 to 4; X is C=O, CH2, SO2 or NR16; when X is C=O, CH2 or SO2, Y is NR17, while when X is NR16, Y is C=O; when Y is NR17, Z is absent, while when Y is C=O, Z is NR18; and W is aryl, a lactam ring or the like.

  含有通式(I)代表的茚满衍生物或其药用盐作为活性成分的心力衰竭补救剂，其中R1是氢、硝基、氰基、氨基、C1-C6烷基羰基氨基或类似物；R2和R3各自独立地是C1-C6烷基或类似物；R4是羟基或C1-C6烷基羰基氧基，或者R4与R5一起代表键或氧；R5 是氢，或者 R5 与 R4 一起代表键或氧； R6 是氢、羟基、NR7R8 或类似物； n 是 0 至 4 的整数； X 是 C=O、CH2、SO2 或 NR16；当 X 是 C=O、CH2 或 SO2 时，Y 是 NR17，而当 X 是 NR16 时，Y 是 C=O；当 Y 是 NR17 时，Z 不存在，而当 Y 是 C=O 时，Z 是 NR18；以及 W 是芳基、内酰胺环或类似物。
• PROCESS FOR PRODUCING RUBBER COMPOSITION
  申请人：Bridgestone Corporation

  公开号：EP2695911A1

  公开（公告）日：2014-02-12

  Provided are processes for producing a rubber composition, which enable a suitably low heat-generating rubber composition to be obtained by further improving coupling function activity of a silane coupling agent. More specifically, provided is a process for producing a rubber composition comprising a rubber component (A) comprising at least one selected from natural rubbers and synthetic diene rubbers, a filler containing an inorganic filler (B), a silane coupling agent (C), and at least two kinds of chemical agents (D) and (E) selected from guanidines, sulfenamides, thiazoles, thiurams, dithiocarbamates, thioureas, and xanthates, wherein the rubber composition is kneaded in a plurality of stages wherein, in the first stage (X) of kneading, the rubber component (A), all or a portion of the inorganic filler (B), all or a portion of the silane coupling agent (C), and at least two kinds of the chemical agents (D) and (E) are added and kneaded. Also provided is a process for producing a rubber composition, wherein the rubber composition is kneaded in a kneading step comprising three or more stages wherein, in the first stage (X) of kneading, the rubber component (A), all or a portion of the inorganic filler (B), all or a portion of the silane coupling agent (C) are kneaded; in a stage (Y) after the first stage but before the last stage of kneading, at least two kinds of the chemical agents (D) and (E) are added and kneaded; and, in the last stage (Z) of kneading, a vulcanizing agent is added and kneaded.

  本发明提供了生产橡胶组合物的工艺，通过进一步提高硅烷偶联剂的偶联功能活性，可获得适当低发热量的橡胶组合物。更具体地说，本发明提供了一种生产橡胶组合物的工艺，该橡胶组合物包括至少一种选自天然橡胶和合成二烯橡胶的橡胶组分（A）、一种含有无机填料的填料（B）、一种硅烷偶联剂（C）以及至少两种选自胍类、亚磺酰胺类、噻唑类、噻嗪类、二硫代氨基甲酸乙酯类、二硫代氨基甲酸乙酯类、二硫代氨基甲酸乙酯类、二硫代氨基甲酸乙酯类、二硫代氨基甲酸乙酯类和二硫代氨基甲酸乙酯类的化学剂（D）和（E）、其中，橡胶组合物分多个阶段捏合，在捏合的第一阶段 (X) 中，加入并捏合橡胶组分 (A)、全部或部分无机填料 (B)、全部或部分硅烷偶联剂 (C) 以及至少两种化学剂 (D) 和 (E)。还提供了一种生产橡胶组合物的工艺，其中橡胶组合物的捏合步骤包括三个或三个以上阶段，在捏合的第一阶段（X），捏合橡胶组分（A）、全部或部分无机填料（B）、全部或部分硅烷偶联剂（C）；在第一阶段之后、最后阶段之前的阶段（Y）中，加入并捏合至少两种化学剂（D）和（E）；以及，在最后阶段（Z）中，加入并捏合硫化剂。
• US6486178B1
  申请人：——

  公开号：US6486178B1

  公开（公告）日：2002-11-26