2-((4-methoxyphenyl)(morpholino)methyl)phenol | 1162692-69-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((4-methoxyphenyl)(morpholino)methyl)phenol
• 英文别名: 2-((4-Methoxyphenyl)(morpholino)methyl) phenol；2-[(4-methoxyphenyl)-morpholin-4-ylmethyl]phenol
• CAS: 1162692-69-4
• 化学式: C₁₈H₂₁NO₃
• 分子量: 299.37
• InChiKey: ZWHCONDKBXKLGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  41.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  甲氧苯胺 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 14.58h， 生成 2-((4-methoxyphenyl)(morpholino)methyl)phenol
  参考文献：
  名称：

  Sequential One-Pot Access to Molecular Diversity through Aniline Aqueous Borylation

  摘要：

  On the basis of our recently reported aniline aqueous borylation, molecular diversity was achieved in a one-pot process by combining other reactions such as esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich.

  DOI：

  10.1021/jo501665e

文献信息

• Magnetically Retrievable Nanocomposite Based on Thiosemicarbazide–Formaldehyde Resin as a Versatile Nucleophilic Scavenger
  作者：Maomin Zhen、Danfeng Zhang、Zeyu Zhang、Yanqing Peng

  DOI：10.1021/acscombsci.6b00090

  日期：2016.12.12

  retrievable nanocomposite was prepared by in situ polycondensation and entrapment of iron oxide nanoparticles. This material was found to be efficient in trapping excess electrophilic reagents such as carbonyl compounds, acid chlorides and isothiocyanates. Advantages of the new scavenger include facile preparation, high loading capacity, low cost, satisfactory swelling properties in polar solvents, and

  通过原位缩聚和包埋氧化铁纳米颗粒制备了可磁性回收的纳米复合材料。发现该材料可有效捕集过量的亲电试剂，例如羰基化合物，酰氯和异硫氰酸酯。新型清除剂的优点包括制备简便，装载量高，成本低，在极性溶剂中具有令人满意的溶胀性能以及方便的磁回收。
• An efficient and green La(OTf)3 catalyzed Petasis borono–Mannich reaction for the synthesis of tertiary amines
  作者：Bijivemula N. Reddy、Chinthaparthi Radha Rani、S. M. Reddy、Madhvesh Pathak

  DOI：10.1007/s11164-016-2551-6

  日期：2016.10

  tertiary amine derivatives have been prepared by a one-pot three-component Petasis borono–Mannich reaction of two different salicylaldehydes and 2-formylpyridine, substituted morpholine/piperidines and aryl boronic acids. These reactions were carried out under microwave irradiation using a catalytic amount of La(OTf)3 in a short reaction time. This procedure has the advantages of high conversions with excellent

  摘要 通过两个不同的水杨醛和2-甲酰基吡啶，取代的吗啉/哌啶和芳基硼酸的一锅三组分Petasis borono-Mannich反应，制备了各种叔胺衍生物。这些反应在微波辐射下在短时间内使用催化量的La（OTf）3进行。该方法具有高转化率和优异的化学选择性的优点。 图形摘要 该方法的吸引人的特点是操作简单，绿色反应，可重用性以及催化剂的高效率和易加工性。
• Chitosan: highly efficient, green, and reusable biopolymer catalyst for the synthesis of alkylaminophenols via Petasis borono–Mannich reaction
  作者：Sirigi Reddy Sudharsan Reddy、Bhoomireddy Rajendra Prasad Reddy、Peddiahgari Vasu Govardhana Reddy

  DOI：10.1016/j.tetlet.2015.07.004

  日期：2015.8

  nafion® 117, PEG-OSO3H, tween® 80, poly styrene –SO3H and chitosan for the preparation of alkylaminophenols through Petasis borono–Mannich reaction by one-pot three component condensation of o-hydroxy aldehydes, secondary amines, and various boronic acids. It was observed that the reaction was completed in a short period of time and the yield was optimum by virtue of chitosan heterogeneous catalyst. Furthermore

  我们筛选了不同的功能化聚合催化剂，如nafion®117，PEG-OSO 3 H，tween®80，聚苯乙烯–SO 3 H和壳聚糖，通过一锅三锅法通过波塔西斯·波罗诺–曼尼希反应制备烷基氨基酚的催化功效。邻羟基醛，仲胺和各种硼酸的组分缩合。观察到反应在短时间内完成，并且由于壳聚糖非均相催化剂的产率是最佳的。此外，可以通过简单的过滤来回收催化剂，并且可以重复使用多达十个循环。从重复使用的第六个周期开始观察到催化活性的平稳损失。
• Three-component, solvent-free synthesis of Betti base catalyzed by sulfated polyborate
  作者：Manisha S. Patil、Chetan K. Khatri、Ganesh U. Chaturbhuj

  DOI：10.1007/s00706-018-2169-z

  日期：2018.8

  this work, efficient, mild, and eco-friendly procedure of 1-aminoalkyl-2-phenol/Betti base from one-pot three-component condensations of aldehyde, phenol, and morpholine in the presence of sulfated polyborate catalyst, under a solvent-free condition at 100 °C, is described. The key advantages of the present method are short reaction time, high yields, aqueous work-up procedure, low cost, stable, reusable

  摘要在这项工作中，在溶剂化硫酸多硼酸盐催化剂存在下，由一锅三元乙醛，苯酚和吗啉的缩合反应制得的1-氨基烷基-2-苯酚/贝蒂碱的高效，温和和环保的方法描述了100°C时的无条件状态。本方法的主要优点是反应时间短，产率高，水后处理程序，成本低，稳定，可重复使用的催化剂和无溶剂的反应条件。 图形概要
• Microwave-assisted nanocatalysis: A CuO NPs/rGO composite as an efficient and recyclable catalyst for the Petasis-borono–Mannich reaction
  作者：Anshu Dandia、Sarika Bansal、Ruchi Sharma、Kuldeep S. Rathore、Vijay Parewa

  DOI：10.1039/c8ra05203d

  日期：——

  CuO NPs/rGO composite was synthesized and characterized by various analytical techniques an used as a recyclable catalyst for Petasis-borono–Mannich reaction under microwave irradiation.

  CuO NPs/rGO复合材料通过各种分析技术合成和表征，并作为可回收催化剂应用于微波辐射下的Petasis-硼酸曼尼希反应。