7-Hydroxy-8-methyl-2-(morpholin-4-yl)-4H-1,3-benzoxazin-4-one | 952106-37-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 7-Hydroxy-8-methyl-2-(morpholin-4-yl)-4H-1,3-benzoxazin-4-one
• 英文别名: 7-hydroxy-8-methyl-2-morpholino-4H-benzo[e][1,3]oxazin-4-one；7-Hydroxy-8-methyl-2-(4-morpholinyl)-4H-1,3-benzoxazin-4-one；7-hydroxy-8-methyl-2-morpholin-4-yl-1,3-benzoxazin-4-one
• CAS: 952106-37-5
• 化学式: C₁₃H₁₄N₂O₄
• 分子量: 262.265
• InChiKey: JFFMRLFYNPUYRY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-Hydroxy-8-methyl-2-(morpholin-4-yl)-4H-1,3-benzoxazin-4-one 、 1-溴-2-氯乙烷 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 反应 20.0h， 以55%的产率得到7-(2-Chloroethoxy)-8-methyl-2-morpholin-4-yl-1,3-benzoxazin-4-one
  参考文献：
  名称：

  Synthesis, identification and antiplatelet evaluation of 2-morpholino substituted benzoxazines

  摘要：

  A number of 2-morpholino substituted benzoxazines have been prepared in order to test their effectiveness against ADP and collagen induced platelet aggregation. The reaction of 2-thio-1,3-benzoxazines with morpholine has been generalised to enable the use of substituted benzoxazines. Two separate methods were used to prepare 7-O-2-morpholino substituted benzoxazines from 7-hydroxy-2-morpholino benzoxazines. Antiplatelet testing was carried out on 15 of the title compounds. 7-(2-Chloroethoxy)-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 15d and 7-[2-(4-methylpiperazin-1-yl)ethoxy]-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 16d showed potent activity against ADP and collagen induced platelet aggregation. The structures of the newly prepared compounds were confirmed by microanalysis as well as the analysis of IR, H-1 and C-13 NMR. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.01.021
• 作为产物：
  描述：

  7-hydroxy-8-methyl-2-thioxo-2,3-dihydro-4H-benz[e]-1,3-oxazin-4-one 、 吗啉 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以80%的产率得到7-Hydroxy-8-methyl-2-(morpholin-4-yl)-4H-1,3-benzoxazin-4-one
  参考文献：
  名称：

  Synthesis, identification and antiplatelet evaluation of 2-morpholino substituted benzoxazines

  摘要：

  A number of 2-morpholino substituted benzoxazines have been prepared in order to test their effectiveness against ADP and collagen induced platelet aggregation. The reaction of 2-thio-1,3-benzoxazines with morpholine has been generalised to enable the use of substituted benzoxazines. Two separate methods were used to prepare 7-O-2-morpholino substituted benzoxazines from 7-hydroxy-2-morpholino benzoxazines. Antiplatelet testing was carried out on 15 of the title compounds. 7-(2-Chloroethoxy)-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 15d and 7-[2-(4-methylpiperazin-1-yl)ethoxy]-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 16d showed potent activity against ADP and collagen induced platelet aggregation. The structures of the newly prepared compounds were confirmed by microanalysis as well as the analysis of IR, H-1 and C-13 NMR. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.01.021

文献信息

• Synthesis, structural elucidation and DNA-dependant protein kinase and antiplatelet studies of 2-amino-[5, 6, 7, 8-mono and 7, 8-di-substituted]-1,3-benzoxazines
  作者：Saleh Ihmaid、Jasim Al-Rawi、Christopher Bradley

  DOI：10.1016/j.ejmech.2010.07.066

  日期：2010.11

  A number of new 2-amino-[5, 6, 7 and 8]-O-substituted 1,3-benzoxazines, and 2-amino 8-methyl-7-O-substituted-1,3-benzoxazines were synthesized. Thirty one new compounds were tested for their effect on collagen induced platelet aggregation and it was found that the most active compounds were 8-methyl-2-morpholin-4-yl-7-(pyridin-3-ylmethoxy)-4H-1,3-benzoxazin-4-one 9f and 8-methyl-2-morpholin-4-yl-7-(pyridin-4-ylmethoxy)-4H-1,3-benzoxazin-4-one 9j with IC(50) = 2 +/- 1.5 and 4 +/- 2 mu M respectively. Inhibition of DNA-PK activity at concentrations of 1.6-4 mu M were tested for 9 products 5i, 7a-e and 9b, 9f and 9j. Crown Copyright (C) 2010 Published by Elsevier Masson SAS. All rights reserved.
• Synthesis, identification and antiplatelet evaluation of 2-morpholino substituted benzoxazines
  作者：Kaylene M. Pritchard、Jasim Al-Rawi、Christopher Bradley

  DOI：10.1016/j.ejmech.2007.01.021

  日期：2007.9

  A number of 2-morpholino substituted benzoxazines have been prepared in order to test their effectiveness against ADP and collagen induced platelet aggregation. The reaction of 2-thio-1,3-benzoxazines with morpholine has been generalised to enable the use of substituted benzoxazines. Two separate methods were used to prepare 7-O-2-morpholino substituted benzoxazines from 7-hydroxy-2-morpholino benzoxazines. Antiplatelet testing was carried out on 15 of the title compounds. 7-(2-Chloroethoxy)-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 15d and 7-[2-(4-methylpiperazin-1-yl)ethoxy]-8-methyl-2-morpholin-4-yl-4H-1,3-benzoxazin-4-one 16d showed potent activity against ADP and collagen induced platelet aggregation. The structures of the newly prepared compounds were confirmed by microanalysis as well as the analysis of IR, H-1 and C-13 NMR. (c) 2007 Elsevier Masson SAS. All rights reserved.