tert-butyl 3-amino-3-(hydroxyimino)propanoate | 218278-67-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tert-butyl 3-amino-3-(hydroxyimino)propanoate
• CAS: 218278-67-2
• 化学式: C₇H₁₄N₂O₃
• 分子量: 174.2
• InChiKey: AKHKDZQXAXCAOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 3-amino-3-(hydroxyimino)propanoate 在 三乙胺 作用下， 生成 tert-butyl 2-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)acetate
  参考文献：
  名称：

  NEW COMPOUNDS FOR TREATING STAPHYLOCOCCUS INFECTIONS

  摘要：

  本发明涉及对Staphylococcus属细菌感染特别是对金黄色葡萄球菌感染有效的新型式(I)抗菌化合物。本发明还涉及制备所述抗菌化合物的方法，包含它们的组合物，以及它们作为药物的用途。

  公开号：

  EP4406952A1
• 作为产物：
  描述：

  氰乙酸叔丁酯 在 羟胺 作用下， 以 乙醇 、 水 为溶剂， 以67%的产率得到tert-butyl 3-amino-3-(hydroxyimino)propanoate
  参考文献：
  名称：

  SPIRO COMPOUND AND USE THEREOF

  摘要：

  本发明旨在提供一种新型SCD抑制剂。本发明涉及一种包括下式（I）所表示的化合物的SCD抑制剂：其中R是一个可选择取代的环基或可选择取代的氨甲酰基，但R不是一个可选择取代的7-吡啶并[2,3-d]嘧啶基团；环A是一个可选择进一步取代的吡啶并嘧啶环；R1、R2、R3、R4、R11、R12、R13和R14分别独立地是氢原子或取代基，或R1和R11的组合体，R2和R12的组合体，R3和R13的组合体，或R4和R14的组合体可选择形成氧基，或R2和R4的组合体可选择形成键或烷基交联；m和n分别独立地是0到2的整数；环B是一个可选择取代的环，但构成环B的两个与螺碳原子相邻的原子不同时为氧原子，或其盐，或其前药。

  公开号：

  US20100069351A1

文献信息

• BRIDGED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20190127358A1

  公开（公告）日：2019-05-02

  The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts or solvates thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as agonists. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

  本发明提供了式（I）的化合物： 或其立体异构体、互变异构体或药学上可接受的盐或溶剂，其中所有变量如本文所定义。这些化合物调节法尼索尔X受体（FXR）的活性，例如作为激动剂。本发明还涉及包括这些化合物的药物组合物以及利用这些化合物和药物组合物治疗与FXR失调相关的疾病、紊乱或病况的方法，例如病理性纤维化、移植排斥、癌症、骨质疏松症和炎症性疾病。
• 4-haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclylpyrimidines, processes for their preparation, compositions comprising them, and their use as pesticides
  申请人：Hoechst Schering AgrEvo GmbH

  公开号：US06239160B1

  公开（公告）日：2001-05-29

  The present invention relates to 4-haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclylpyrimidines of the formula (I), to processes for their preparation, to compositions comprising them, and to the use of these compounds for controlling animal pests, in particular insects, spider mites, ectoparasites and helminths. In the formula (I), Q is a 5-membered heterocyclic group which is optionally substituted by halogen or organic radicals, Y is halo-C1-C8-alkyl, X is CH or N and m is 0 or 1.

  本发明涉及式(I)的4-卤代烷基-3-杂环基吡啶和4-卤代烷基-5-杂环基嘧啶，以及它们的制备方法、包含它们的组合物，以及利用这些化合物来控制动物害虫，特别是昆虫、蜘蛛螨、外寄生虫和蠕虫。在式(I)中，Q是一个5-成员杂环基，可选择地被卤素或有机基取代，Y是卤代C1-C8-烷基，X是CH或N，m为0或1。
• 4-haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, processes for their preparation, compositions comprising them, and their use as pesticides
  申请人：——

  公开号：US20030162812A1

  公开（公告）日：2003-08-28

  The present invention relates to 4-Haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, Processes for Their Preparation, Compositions Comprising Them, and Their Use as Pesticides More particularly, the present invention relates to 4-trifluoromethyl-3-oxadiazolylpyridines of the formula (I′), to processes for their preparation, to compositions comprising them and to the use of these compounds for controlling animal pests, in particular insects, spider mites, ectoparasites and helminths: 1 wherein X, Y are as defined in the description.

  本发明涉及4-卤代烷基-3-杂环基吡啶、4-卤代烷基-5-杂环基嘧啶和4-三氟甲基-3-噁二唑基吡啶，以及它们的制备方法、包含它们的组合物和它们作为杀虫剂的用途。更具体地，本发明涉及式(I′)的4-三氟甲基-3-噁二唑基吡啶，其制备方法，包含它们的组合物以及这些化合物用于控制动物害虫，特别是昆虫、蜘蛛螨、外寄生虫和蠕虫的用途：其中X、Y如描述中所定义。
• 4-HALOALKYL-3-HETEROCYCLYLPYRIDINES, 4-HALOALKYL-5-HETEROCYCLYL-PYRIMIDINES AND 4-TRIFLUOROMETHYL-3-OXADIAZOLYLPYRIDINES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS COMPRISING THEM, AND THEIR USE AS PESTICIDES
  申请人：Hoechst Schering AgrEvo GmbH

  公开号：US06699853B2

  公开（公告）日：2004-03-02

  The present invention relates to 4-Haloalkyl-3-heterocyclylpyridines, 4-haloalkyl-5-heterocyclyl-pyrimidines and 4-trifluoromethyl-3-oxadiazolylpyridines, Processes for Their Preparation, Compositions Comprising Them, and Their Use as Pesticides More particularly, the present invention relates to 4-trifluoromethyl-3-oxadiazolylpyridines of the formula (I′), to processes for their preparation, to compositions comprising them and to the use of these compounds for controlling animal pests, in particular insects, spider mites, ectoparasites and helminths: wherein X, Y are as defined in the description.

  本发明涉及4-卤代烷基-3-杂环基吡啶、4-卤代烷基-5-杂环基嘧啶和4-三氟甲基-3-氧代噻唑基吡啶，它们的制备方法，包含它们的组合物以及它们作为杀虫剂的用途。更具体地，本发明涉及式(I′)的4-三氟甲基-3-氧代噻唑基吡啶，其制备方法，包含它们的组合物以及利用这些化合物控制动物害虫，特别是昆虫、蜘蛛螨、寄生虫和蠕虫的用途：其中X、Y如描述中所定义。
• 4-Haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclyl-pyrimidines, processes for their preparation, compositions comprising them, and their use as pesticides
  申请人：——

  公开号：US20020013326A1

  公开（公告）日：2002-01-31

  4-Haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclyl-pyrimidines, processes for their preparation, compositions comprising them, and their use as pesticides The present invention relates to 4-haloalkyl-3-heterocyclylpyridines and 4-haloalkyl-5-heterocyclylpyrimidines of the formula (I), to processes for their preparation, to compositions comprising them, and to the use of these compounds for controlling animal pests, in particular insects, spider mites, ectoparasites and helminths. 1 In the formula (I), Q is a 5-membered heterocyclic group which is optionally substituted by halogen or organic radicals, Y is halo-C 1 -C 6 -alkyl, X is CH or N and m is 0 or 1.

  本发明涉及式(I)的4-卤代烷基-3-杂环基吡啶和4-卤代烷基-5-杂环基嘧啶，以及它们的制备方法、包含它们的组合物，以及这些化合物作为农药控制动物害虫，特别是昆虫、蜘蛛螨、外寄生虫和寄生虫的用途。 式(I)中，Q是一个5元杂环基团，可选择地被卤素或有机基团取代，Y是卤代C1-C6-烷基，X是CH或N，m为0或1。