N'-hexanoyl-N-tosylhydrazine | 330441-29-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-hexanoyl-N-tosylhydrazine
• 英文别名: N'-[(4-methylphenyl)sulfonyl]hexanehydrazide；N'-(4-methylphenyl)sulfonylhexanehydrazide
• CAS: 330441-29-7
• 化学式: C₁₃H₂₀N₂O₃S
• 分子量: 284.379
• InChiKey: DTZYGAJPQZETOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  己酸酐 、 对甲苯磺酰肼 以 二氯甲烷 为溶剂， 反应 1.5h， 以83%的产率得到N'-hexanoyl-N-tosylhydrazine
  参考文献：
  名称：

  4-Aminopyridine Catalyzed Direct and Regioselective Acylation of N-Tosylhydrazide

  摘要：

  An efficient and simple method for selective acylation of either one of two nitrogen atoms of tosylhydrazide was developed. The selectivity was drastically controlled by a catalytic amount of 4-aminopyridine or 4-(dimethylamino)pyridine with common acylating agents. The nitrogen atom masked with a tosyl group was acylated in the presence of 4-aminopyridine, whereas the primary nitrogen atom was acylated in the absence of 4-aminopyridine.

  DOI：

  10.1021/ol9021194

文献信息

• 4-Aminopyridine Catalyzed Direct and Regioselective Acylation of <i>N</i>-Tosylhydrazide
  作者：Kosuke Namba、Isamu Shoji、Mugio Nishizawa、Keiji Tanino

  DOI：10.1021/ol9021194

  日期：2009.11.5

  An efficient and simple method for selective acylation of either one of two nitrogen atoms of tosylhydrazide was developed. The selectivity was drastically controlled by a catalytic amount of 4-aminopyridine or 4-(dimethylamino)pyridine with common acylating agents. The nitrogen atom masked with a tosyl group was acylated in the presence of 4-aminopyridine, whereas the primary nitrogen atom was acylated in the absence of 4-aminopyridine.