Piperidine, 1-benzoyl-4-(1,2-dihydro-2-oxo-4-quinazolinyl)- | 92311-27-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Piperidine, 1-benzoyl-4-(1,2-dihydro-2-oxo-4-quinazolinyl)-
• CAS: 92311-27-8
• 化学式: C₂₀H₁₉N₃O₂
• 分子量: 333.4
• InChiKey: MBOHHIIDHWNITJ-UHFFFAOYSA-N

物化性质

• 熔点：
  >300 °C(Solv: ethanol (64-17-5))
• 密度：
  1.30±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Synthesis of piperidine derivatives with a quinazoline ring system as potential antihypertensive agents.
  作者：HARUKI TAKAI、HIROYUKI OBASE、MASAYUKI TERANISHI、AKIRA KARASAWA、KAZUHIRO KUBO、KATSUICHI SHUTO、YUTAKA KASUYA、KOKI SHIGENOBU

  DOI：10.1248/cpb.34.1907

  日期：——

  A series of piperidine derivatives with a 2-oxo-1, 2, 3, 4-tetrahydro-quinazoline or 2, 4-dioxo-1, 2, 3, 4-tetrahydroquinazoline ring at the 4-position were prepared and tested for antihypertensive activity. Among the compounds tested, 1-[2-hydroxy-2-(3, 4-methylenedioxyphenyl)ethyl]-4-(2, 4-dioxo-1, 2, 3, 4-tetrahydro-3-quinazolinyl)piperidine (20) and 1-[2-(4-chlorophenyl)-2-hydroxyethyl]-4-(2-oxo-1, 2, 3, 4-tetrahydro-3-quinazolinylmethyl)piperidine (30) produced relatively strong hypotension in the spontaneously hypertensive rat model.

  一系列以2-氧代-1, 2, 3, 4-四氢喹唑啉或2, 4-二氧代-1, 2, 3, 4-四氢喹唑啉环在4位的哌啶衍生物被合成并测试了其抗高血压活性。在测试的化合物中，1-[2-羟基-2-(3, 4-亚甲基二氧基苯基)乙基]-4-(2, 4-二氧代-1, 2, 3, 4-四氢-3-喹唑啉基)哌啶（20）和1-[2-(4-氯苯基)-2-羟基乙基]-4-(2-氧代-1, 2, 3, 4-四氢-3-喹唑啉基甲基)哌啶（30）在自发性高血压大鼠模型中产生了相对较强的降压效果。
• Synthesis and bioactivities of novel piperidylpyrimidine derivatives: inhibitors of tumor necrosis factor-alpha production
  作者：Norio Fujiwara、Hitoshi Fujita、Kiyotaka Iwai、Ayumu Kurimoto、Shinobu Murata、Hajime Kawakami

  DOI：10.1016/s0960-894x(00)00227-4

  日期：2000.6

  New piperidylpyrimidine derivatives, including quinazolines, were prepared, and their abilities to inhibit TNF-alpha production evaluated. Some compounds showed potent inhibitory activity in mouse macrophages stimulated with LPS. The synthesis and structure-activity relationships of these compounds are described. (C) 2000 Elsevier Science Ltd. All rights reserved.
• TAKAI HARUKI; OBASE HIROYUKI; TERANISHI MASAYUKI; KARASAWA AKIRA; KUBO KA+, CHEM. AND PHARM. BULL., 34,(1986) N 5, 1907-1916
  作者：TAKAI HARUKI、 OBASE HIROYUKI、 TERANISHI MASAYUKI、 KARASAWA AKIRA、 KUBO KA+

  DOI：——

  日期：——