N-Isopentyl-p-toluidin | 14426-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Isopentyl-p-toluidin
• 英文别名: 4-methyl-N-(3-methylbutyl)aniline
• CAS: 14426-15-4
• 化学式: C₁₂H₁₉N
• mdl: MFCD11147199
• 分子量: 177.29
• InChiKey: LXFHYFSYVZYKNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 锌 作用下， 生成 N-Isopentyl-p-toluidin
  参考文献：
  名称：

  Condensations of Aromatic Amines with Formaldehyde in Media Containing Acid. VII. The Polymeric States and Structures of Some Anhydro-p-(alkylamino)-benzyl Alcohols

  摘要：

  DOI：

  10.1021/ja01284a023

文献信息

• Ruthenium-Catalyzed Nitro and Nitrile Compounds Coupling with Alcohols: Alternative Route for N-Substituted Amine Synthesis
  作者：Xinjiang Cui、Yan Zhang、Feng Shi、Youquan Deng

  DOI：10.1002/chem.201003095

  日期：2011.2.25

  The one‐pot synthesis of N‐substituted secondary amines from nitrobenzenes and benzonitriles has been developed (see scheme). This report presents a versatile and simple method for the synthesis of N‐substituted amines in excellent yield and high efficiency from nitro and nitrile compounds with alcohols.

  已经开发了由硝基苯和苄腈一锅法合成N取代的仲胺的方法（请参见方案）。本报告提出了一种由硝基和腈化合物与醇类以优异的收率和高效率合成N-取代胺的通用且简便的方法。
• Reductive N-Alkylation of Nitro Compounds to <i>N</i>-Alkyl and <i>N</i>,<i>N</i>-Dialkyl Amines with Glycerol as the Hydrogen Source
  作者：Xinjiang Cui、Youquan Deng、Feng Shi

  DOI：10.1021/cs400049b

  日期：2013.5.3

  As the sustainable and promising hydrogen source, here, glycerol was directly used as the hydrogen source for the reductive amination of alcohol using nitrobenzene as the starting material. The amination of alcohols, especially aliphatic alcohols with different structures, was realized, and mono- or disubstituted amines were synthesized with excellent yields. The reaction mechanism was also explored

  作为可持续和有前途的氢源，此处，甘油直接用作氢源，以硝基苯为起始原料对醇进行还原胺化。实现了醇特别是具有不同结构的脂族醇的胺化，并且以优异的产率合成了单取代或二取代的胺。还探讨了反应机理。
• Synthesis of quinolines via ruthenium-catalysed amine exchange reaction between anilines and trialkylamines
  作者：Chan Sik Cho、Byoung Ho Oh、Joon Seok Kim、Tae-Jeong Kim、Sang Chul Shim

  DOI：10.1039/b005966h

  日期：——

  Anilines react with an array of trialkylamines in the presence of a catalytic amount of RuCl3·nH2O and bis(diphenylphosphino)methane together with SnCl2·2H2O and hex-1-ene as hydrogen acceptor in dioxane at 180 °C to afford the corresponding 2,3-disubstituted quinolines in moderate to good yields.

  苯胺与一系列三烷基胺在催化量的 RuCl3-nH2O 和双（二苯基膦）甲烷以及 SnCl2-2H2O 和作为氢接受体的 1-己烯的存在下，于二噁烷中在 180 °C 下发生反应，生成相应的 2,3-二取代喹啉，收率中等至良好。
• MOENOMYCIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF
  申请人：Kahne Daniel

  公开号：US20110136759A1

  公开（公告）日：2011-06-09

  The present invention provides novel moenomycin analogs as well as pharmaceutical compositions thereof, methods of synthesis, and methods of use in treating an infection by administering an inventive compound to a subject in need thereof. The moenomycin analogs may be prepared synthetically, biosynthetically, or semi-synthetically. The analogs are particularly useful in treating or preventing infections caused by Gram-positive organisms. Certain inventive compounds may have a broader spectrum of coverage, which includes Gram-negative organisms.

  本发明提供了新型的莫诺霉素类似物及其制药组合物，合成方法以及将创新化合物用于治疗感染的方法，通过将创新化合物给予需要治疗的受试者来治疗感染。莫诺霉素类似物可以通过化学合成，生物合成或半合成的方式制备。这些类似物在治疗或预防由革兰氏阳性菌引起的感染中特别有用。某些创新化合物可能具有更广泛的覆盖范围，包括革兰氏阴性菌。
• Reduction Studies of Schiff Bases. III. The Condensations of Certain Secondary Aromatic Amines with Formaldehyde in Acid Solution; Nuclear or N-Methylations by Means of Formaldehyde
  作者：E. C. Wagner

  DOI：10.1021/ja01329a042

  日期：1933.2