Phosgen toluene | 90269-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Phosgen toluene
• 英文别名: carbonyl dichloride;toluene
• CAS: 90269-01-5
• 化学式: C8H8Cl2O
• 分子量: 191.05
• InChiKey: MTMNJFGEKOYMIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.58
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-氯-2-氟-5-(1-甲基乙氧基)-苯胺 、 Phosgen toluene 以 甲苯 为溶剂， 以to give 26 g of 4-chloro-2-fluoro-5-isopropoxy-phenyl isocyanate as pale yellow crystals的产率得到4-chloro-2-fluoro-5-isopropyloxyphenyl isocyanate
  参考文献：
  名称：

  4-(2-fluoro-4-halo-5-substituted phenyl)urazols, and herbicidal use

  摘要：

  一种缩合的苯基尿唑，其化学式为：##STR1## 其中X为氯原子或溴原子，Y和Z分别为氧原子或硫原子，R为C.sub.1-C.sub.3烷基、烯丙基或丙炔基，n为4或5的整数，可用作除草剂。

  公开号：

  US04622063A1

文献信息

• UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION
  申请人：Chen Dawei

  公开号：US20090082261A1

  公开（公告）日：2009-03-26

  The invention provides compounds urea-containing peptide compounds of Formula I and the pharmaceutically salts and hydrates thereof. The variables T, R 1 -R 9 , J, L, M, Y, Z, m, n, and t are defined herein. Certain compounds of Formula I are useful as antiviral agents. Certain urea-containing peptide compounds disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. The invention also provides pharmaceutical compositions containing one or more urea containing peptides compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents. Such pharmaceutical compositions may contain a urea containing peptides compound as the only active agent or may contain a combination of a urea containing peptides compound and one or more other pharmaceutically active agents. The invention also provides methods for treating viral infections, including Hepatitis C infections, in mammals.

  本发明提供了含有尿素的多肽化合物，其结构如式I所示，以及它们的药物盐和 hydrates（水合物）。 变量T，R1-R9，J，L，M，Y，Z，m，n和t在此文中定义。式I中的某些化合物作为抗病毒剂是有用的。本文中公开的某些含尿素的多肽化合物是病毒复制的强效和/或选择性抑制剂，尤其是丙型肝炎病毒复制。本发明还提供了包含一个或多个含尿素多肽化合物以及一个或多个药物可接受载体、辅料或稀释剂的药物组合物。这样的药物组合物可以仅含有一个含尿素多肽化合物作为唯一的活性成分，也可以包含一个含尿素多肽化合物与一个或多个其他药物活性成分的组合。本发明还提供了治疗哺乳动物中病毒感染的方法，包括丙型肝炎感染。
• DYNAMIC UREA BONDS WITH FAST HYDROLYTIC KINETICS FOR POLYMERS
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US20190092898A1

  公开（公告）日：2019-03-28

  The present invention relates to polymers having dynamic urea bonds and more specifically to polymers having hindered urea bonds (HUBs) with fast hydrolytic kinetics. These urea bonds are aryl-substituted, i.e. aromatic-substituted hindered urea bonds, that demonstrate pH independent hydrolytic kinetics, such that they consistently and rapidly hydrolyze in water from pH 2 to 11. The urea bond dissociation for these materials is generally such that k −1 >h −1 , which is two orders of magnitudes faster than for aliphatic hindered ureas. The present invention also relates to hydrolytically reversible or degradable linear, branched or network polymers incorporating these HUBs and to precursors for incorporation of these HUBs into these polymers. The technology can be applied to and integrated into a variety of polymers, such as polyureas, polyurethanes, polyesters, polyamides, polycarbonates, polyamines, and polysaccharides to make linear, branched, and cross-linked polymers. Polymers incorporating these HUBs can be used in a wide variety of applications including for example, environmentally compatible packaging materials and biomedical applications, such as drug delivery systems and tissue engineering. In other embodiments, the HUBs can be used in self-healing polymers.

  本发明涉及具有动态脲键的聚合物，更具体地涉及具有阻碍脲键（HUBs）并具有快速水解动力学的聚合物。这些脲键是芳基取代的，即芳基取代的阻碍脲键，表现出pH无关的水解动力学，因此它们在pH 2至11的水中始终快速水解。这些材料的脲键解离通常是k−1>h−1，比脂肪族阻碍脲酰快两个数量级。本发明还涉及水解可逆或可降解的线性、支化或网络聚合物，其中包含这些HUBs，并涉及用于将这些HUBs纳入这些聚合物中的前体。这项技术可以应用和整合到各种聚合物中，如聚脲，聚氨酯，聚酯，聚酰胺，聚碳酸酯，聚胺，聚糖等，以制备线性、支化和交联聚合物。包含这些HUBs的聚合物可以用于各种应用，例如，环境兼容的包装材料和生物医学应用，如药物传递系统和组织工程。在其他实施例中，这些HUBs可以用于自修复聚合物中。
• N-(2-Fluoro-4-halo-5-substituted phenyl) hydantoins
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04427438A1

  公开（公告）日：1984-01-24

  A composition comprising an N-(2-fluoro-4-halo-5-substituted phenyl) hydantoin of the formula: ##STR1## wherein X is a chlorine atom or a bromine atom and R.sup.1 and R.sup.2 are, same or different, each a C.sub.1 -C.sub.4 alkyl group, a cyclopropyl group, a C.sub.3 -C.sub.4 alkenyl group or a C.sub.3 -C.sub.4 alkynyl group and an inert carrier, which is useful as a herbicide.

  一种化合物，包括公式为：##STR1##的N-(2-氟-4-卤-5-取代苯基)海因酰脲，其中X是氯原子或溴原子，R.sup.1和R.sup.2是相同或不同的C.sub.1-C.sub.4烷基、环丙基、C.sub.3-C.sub.4烯基或C.sub.3-C.sub.4炔基，以及一种惰性载体，该化合物可用作除草剂。
• 2-(2-Fluoro-4-halo-5-substituted phenyl) hydantoins and use
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04437877A1

  公开（公告）日：1984-03-20

  A herbicidal composition which comprises as an active ingredient a compound of the formula: ##STR1## wherein X is a chlorine atom or a bromine atom, Y is --CH.sub.2 --, --S-- or --SO.sub.2 -- and R is a C.sub.1 -C.sub.4 alkyl group, an allyl group or a propargyl group, and an inert carrier.

  一种除草剂组合物，其活性成分为以下化合物：##STR1## 其中X为氯原子或溴原子，Y为--CH.sub.2 --、--S--或--SO.sub.2 --，R为C.sub.1-C.sub.4烷基、烯丙基或丙炔基，以及惰性载体。
• 1-Nitrophenylquinazoline-2,4(1H,3H)-diones
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：US04016166A1

  公开（公告）日：1977-04-05

  The compounds of the present invention can be represented by the following formula: ##STR1## wherein R is selected from the group consisting of hydrogen, lower alkyl, unsaturated lower alkyl, substituted lower alkyl and aralkyl; X is selected from the group consisting of O and S, possessing a high degree of pharmacological activities such as anti-inflammatory, analgetic, and central nervous system depressive activities, and certain of them are useful as new anti-inflammatory agents, analgesics and central nervous system depressants.

  本发明的化合物可以用以下公式表示： ##STR1## 其中R选择自氢、低级烷基、不饱和低级烷基、取代低级烷基和芳基烷基的群组；X选择自O和S，具有高度的药理活性，例如抗炎、镇痛和中枢神经系统抑制活性，其中一些有用作新的抗炎药、镇痛剂和中枢神经系统抑制剂。