Methyl-{1-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-ethyl}-amine | 126002-06-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl-{1-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-ethyl}-amine
• 英文别名: N-methyl-N-(1-methyl-2-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}ethyl)amine；N-methyl-1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]propan-2-amine
• CAS: 126002-06-0
• 化学式: C₁₆H₂₆N₂O
• 分子量: 262.395
• InChiKey: NNPDSGOSEUCKIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  24.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲羟苯丙胺 、 N-(2-氯乙基)吡咯烷盐酸盐 在 sodium hydroxide 作用下， 以 水 、 异丙醇 为溶剂， 反应 3.0h， 生成 Methyl-{1-methyl-2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-ethyl}-amine
  参考文献：
  名称：

  Kmonicek, Vojtech; Vejdelek, Zdenek; Holubek, Jiri, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 6, p. 1721 - 1733

  摘要：

  DOI：

文献信息

• KMONICEK, VOJTECH;VEJDELEK, ZDENEK;HOLUBEK, JIRI;VALCHAR, MARTIN;PROTIVA,+, COLLECT. CZECHOSL. CHEM. COMMUN., 54,(1989) N, C. 1721-1733
  作者：KMONICEK, VOJTECH、VEJDELEK, ZDENEK、HOLUBEK, JIRI、VALCHAR, MARTIN、PROTIVA,+

  DOI：——

  日期：——
• [EN] SMALL MOLECULE ANTAGONISTS OF PF4 CONTAINING ULTRA LARGE COMPLEXES<br/>[FR] ANTAGONISTES À PETITES MOLÉCULES DE PF4 CONTENANT DES COMPLEXES ULTRA-LARGES
  申请人：TRUSTEES OF THE UNIVERSITY OF PENSYLVANIA

  公开号：WO2013142328A1

  公开（公告）日：2013-09-26

  Methods for preventing formation of or disrupting PF4 tetramers are provided. The compounds useful in such methods bind to a PF4 tetramer, dimer, or monomer. The compounds are also useful for preventing formation of or disrupting ultra-large complexes containing a PF4 tetramer and a glycosaminoglycan, and thus have utility toward preventing or treating medical conditions related to the formation of PF4 tetramers, such as HITT and atherosclerosis and toward correcting a platelet imbalance, preventing a decrease in platelet production and increasing high density lipoproteins in a subject. Also provided are compositions and kits containing these compounds and optional medications which cause the formation of PF4 tetramers, and/or medications which disrupt PF4 tetramers. [Formula I]
• Kmonicek, Vojtech; Vejdelek, Zdenek; Holubek, Jiri, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 6, p. 1721 - 1733
  作者：Kmonicek, Vojtech、Vejdelek, Zdenek、Holubek, Jiri、Valchar, Martin、Protiva, Miroslav

  DOI：——

  日期：——