2,2,2-trichloro-1,1-di(4-chloronaphthyl)ethane | 123882-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2,2,2-trichloro-1,1-di(4-chloronaphthyl)ethane
• 英文别名: 1,1,1-trichloro-2,2-bis(4-chloro-1-naphthyl)ethane；1,1,1-Trichlor-2,2-bis-(4-chlor-[1]naphthyl)-aethan；1-Chloro-4-[2,2,2-trichloro-1-(4-chloronaphthalen-1-yl)ethyl]naphthalene；1-chloro-4-[2,2,2-trichloro-1-(4-chloronaphthalen-1-yl)ethyl]naphthalene
• CAS: 123882-17-7
• 化学式: C₂₂H₁₃Cl₅
• 分子量: 454.61
• InChiKey: RTBYANOJAFVJMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2,2,2-trichloro-1,1-di(4-chloronaphthyl)ethane 在 氨 、 锌 作用下， 生成 trans-1,2-bis-(4-chloro-[1]naphthyl)-ethene
  参考文献：
  名称：

  Riemschneider, Zeitschrift fur Angewandte Entomologie, 1956, vol. 38, p. 105,115

  摘要：

  DOI：
• 作为产物：
  描述：

  水合氯醛 、 1-氯萘 在 硫酸 作用下， 生成 2,2,2-trichloro-1,1-di(4-chloronaphthyl)ethane
  参考文献：
  名称：

  Localised enamel hypoplasia of human deciduous canines: genotype or environment?

  摘要：

  AbstractA discrete area of defective enamel formation that appears on the labial surface of the crowns of deciduous canine teeth has been described in both recent and prehistoric human population, with reported frequencies varying from 1 to 45 per cent. Suggestions about the aetiology of this localized hypoplasia range from genotypic factors to environmental conditions and systemic effects. The major aims of this study were to describe the frequency of occurrence and pattern of expression of the lesion in Australian Aboriginal and Caucasian ethnic groups, and to clarify the role of genetic factors by examining a sample of twins.The study sample consisted of dental casts of 181 pairs of Australian Caucasian twins, 215 Aborigines and 122 Caucasian singletons, together with 253 extracted deciduous canines. Examination of dental casts and extracted teeth was undertaken under 2X magnification with emphasis being placed upon location and expression of the lesion.The defect was observed in 49 per cent of twins and 44 per cent of Aborigines, but only 36 per cent of singletons. The percentages of affected teeth in each group were: 18 per cent in twins, 17 per cent in Aborigines and 13 per cent in Caucasians. A significant proportion of the defects occurred on the mesial aspect of the labial surface, in the middle area incisocervically, with the majority in the lower jaw. Anumber of significant differences in frequency were observed between groups, sexes, arches and sides.The results confirm some of the findings of previous studies, but also suggest that none of environmental, genetic or systemic factors can be ruled out as being involved in aetiology of the defect. The higher incidence of the lesion occurring on the mesial aspect of the labial surface is suggestive of physical trauma. Also, the vulnerability of the prominent developing mandibular canine, with its thin or missing labial covering of bone, would be expected to lead to higher prevalence of the lesion in the lower jaw. Although not definitive, the results of concordance analyses in twins were suggestive of a possible genetic predisposition in the formation of the lesion. Further research with a greater clinical orientation and emphasis on determing specific aetiological factors within any given environment in different ethnic groups may provide better insight into the ambiguous aetiology of the hypoplastic enamel defect.

  DOI：

  10.1111/j.1834-7819.2000.tb00246.x

文献信息

• Synthesis of annulated oligothiophenes
  作者：V. G. Nenajdenko、E. S. Balenkova、K. Y. Chernichenko、S. S. Vshivenko

  DOI：10.1007/s11172-012-0188-1

  日期：2012.7

  Reactions of 1,1-di(2-naphthyl)-2,2-dichloroethene and 1,1-di(2-benzothienyl)-2,2-dichloroethene with sulfur at 220–225 °C resulted in hitherto unknown oligothiophenes. Tetrathio[6]helicene was synthesized from 1,1-di(3-benzothienyl)-2,2-dichloroethene. Preparative pathway to helicene involving intramolecular ring closure of dithiol derived from 1,1-di-(3-benzothienyl)-2,2-dichloroethene was developed as an alternative to high temperature synthesis.

  1,1-二（2-萘基）-2,2-二氯乙烯和1,1-二（2-苯并噻烷基）-2,2-二氯乙烯与硫在220-225°C下反应生成了迄今为止未知的寡硫烯。四硫[6]螺旋烯是由1,1-二（3-苯并噻烷基）-2,2-二氯乙烯合成的。开发了一条合成螺旋烯的新路径，该路径涉及从1,1-二（3-苯并噻烷基）-2,2-二氯乙烯衍生的二硫醇的分子内环闭合，作为高温合成的替代方案。
• Derivatives of 1,1,1-Trichloro-2,2-diphenylethane
  作者：L. Haskelberg、D. Lavie

  DOI：10.1021/ja01202a008

  日期：1947.10
• Gates, Reginald A.; D'Agostino, Michael F.; Sutin, Karen A., Organometallics, 1990, vol. 9, # 1, p. 20 - 26
  作者：Gates, Reginald A.、D'Agostino, Michael F.、Sutin, Karen A.、McGlinchey, Michael J.、Janik, Thomas S.、Churchill, Melvyn Rowen

  DOI：——

  日期：——
• Localised enamel hypoplasia of human deciduous canines: genotype or environment?
  作者：Sue Taji、Toby Hughes、Jim Rogers、Grant Townsend

  DOI：10.1111/j.1834-7819.2000.tb00246.x

  日期：2000.6

  AbstractA discrete area of defective enamel formation that appears on the labial surface of the crowns of deciduous canine teeth has been described in both recent and prehistoric human population, with reported frequencies varying from 1 to 45 per cent. Suggestions about the aetiology of this localized hypoplasia range from genotypic factors to environmental conditions and systemic effects. The major aims of this study were to describe the frequency of occurrence and pattern of expression of the lesion in Australian Aboriginal and Caucasian ethnic groups, and to clarify the role of genetic factors by examining a sample of twins.The study sample consisted of dental casts of 181 pairs of Australian Caucasian twins, 215 Aborigines and 122 Caucasian singletons, together with 253 extracted deciduous canines. Examination of dental casts and extracted teeth was undertaken under 2X magnification with emphasis being placed upon location and expression of the lesion.The defect was observed in 49 per cent of twins and 44 per cent of Aborigines, but only 36 per cent of singletons. The percentages of affected teeth in each group were: 18 per cent in twins, 17 per cent in Aborigines and 13 per cent in Caucasians. A significant proportion of the defects occurred on the mesial aspect of the labial surface, in the middle area incisocervically, with the majority in the lower jaw. Anumber of significant differences in frequency were observed between groups, sexes, arches and sides.The results confirm some of the findings of previous studies, but also suggest that none of environmental, genetic or systemic factors can be ruled out as being involved in aetiology of the defect. The higher incidence of the lesion occurring on the mesial aspect of the labial surface is suggestive of physical trauma. Also, the vulnerability of the prominent developing mandibular canine, with its thin or missing labial covering of bone, would be expected to lead to higher prevalence of the lesion in the lower jaw. Although not definitive, the results of concordance analyses in twins were suggestive of a possible genetic predisposition in the formation of the lesion. Further research with a greater clinical orientation and emphasis on determing specific aetiological factors within any given environment in different ethnic groups may provide better insight into the ambiguous aetiology of the hypoplastic enamel defect.
• Riemschneider, Zeitschrift fur Angewandte Entomologie, 1956, vol. 38, p. 105,115
  作者：Riemschneider

  DOI：——

  日期：——