hydroxyimino-acetic acid-(5-chloro-2-methoxy-anilide) | 67303-24-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: hydroxyimino-acetic acid-(5-chloro-2-methoxy-anilide)
• 英文别名: Hydroxyimino-essigsaeure-(5-chlor-2-methoxy-anilid)；Oximinoessigsaeure-(5-chlor-2-methoxy-anilid)；Isonitrosoacet-(5-chlor-2-methoxy-anilid)；N-(5-chloro-2-methoxyphenyl)-2-hydroxyiminoacetamide
• CAS: 67303-24-6
• 化学式: C₉H₉ClN₂O₃
• 分子量: 228.635
• InChiKey: PQBVQTQRUFZFOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  hydroxyimino-acetic acid-(5-chloro-2-methoxy-anilide) 在 硫酸 作用下， 生成 4-氯-7-甲氧基靛红
  参考文献：
  名称：

  Sandmeyer, Helvetica Chimica Acta, 1919, vol. 2, p. 239

  摘要：

  DOI：
• 作为产物：
  描述：

  Acetic acid acetoxy-(5-chloro-2-methoxy-phenylcarbamoyl)-methyl ester 在 盐酸羟胺 作用下， 以 乙醇 、 水 为溶剂， 反应 2.0h， 生成 hydroxyimino-acetic acid-(5-chloro-2-methoxy-anilide)
  参考文献：
  名称：

  An improved synthesis of isonitrosoacetanilides

  摘要：

  A novel two-step synthesis of isonitrosoacetanilides [2-(hydroxyimino)-N-phenylacetamides] has been developed, involving the initial acylation of aniline derivatives with 2,2-diacetoxyacetyl chloride, followed by reaction with hydroxylamine hydrochloride. The method works equally well with a variety of different aniline derivatives, including those with poor aqueous solubility and those containing electron rich ortho-substituents, neither of which react well under traditional conditions. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.10.046

文献信息

• DE320647
  申请人：——

  公开号：——

  公开（公告）日：——
• Martinet; Coisset, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1921, vol. 172, p. 1235
  作者：Martinet、Coisset

  DOI：——

  日期：——
• Martinet; Caisset, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1921, vol. 172, p. 1234
  作者：Martinet、Caisset

  DOI：——

  日期：——
• Sandmeyer, Helvetica Chimica Acta, 1919, vol. 2, p. 239
  作者：Sandmeyer

  DOI：——

  日期：——
• An improved synthesis of isonitrosoacetanilides
  作者：Gordon W. Rewcastle、Hamish S. Sutherland、Claudette A. Weir、Adrian G. Blackburn、William A. Denny

  DOI：10.1016/j.tetlet.2005.10.046

  日期：2005.12

  A novel two-step synthesis of isonitrosoacetanilides [2-(hydroxyimino)-N-phenylacetamides] has been developed, involving the initial acylation of aniline derivatives with 2,2-diacetoxyacetyl chloride, followed by reaction with hydroxylamine hydrochloride. The method works equally well with a variety of different aniline derivatives, including those with poor aqueous solubility and those containing electron rich ortho-substituents, neither of which react well under traditional conditions. (c) 2005 Elsevier Ltd. All rights reserved.