1,1'-methylenebis(pyrrolid-2-one) | 61324-75-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,1'-methylenebis(pyrrolid-2-one)
• 英文别名: 1,1'-methylenebis-2-pyrrolidinone；methylene bis N-pyrrolidinone-2；1,1'-methanediyl-bis-pyrrolidin-2-one；1,1'-Methandiyl-bis-pyrrolidin-2-on；methylene bispyrrolidone；1,1'-Methylen-di-2-pyrrolidinon；1,1'-Methylenedi-2-pyrrolidinone；1-[(2-oxopyrrolidin-1-yl)methyl]pyrrolidin-2-one
• CAS: 61324-75-2
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: CGGQYPNGNKEBLE-UHFFFAOYSA-N

物化性质

• 熔点：
  74 °C
• 沸点：
  90 °C(Press: 0.05 Torr)
• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1'-methylenebis(pyrrolid-2-one) 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 24.0h， 以85%的产率得到1-(吡咯烷-1-基甲基)吡咯烷
  参考文献：
  名称：

  Miquel, Christian; Pigache, Pierre; Rigo, Benoit, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 1447 - 1453

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(氯甲基)吡咯烷-2-酮 在 1-三甲基硅基吡咯酮 作用下， 以85%的产率得到1,1'-methylenebis(pyrrolid-2-one)
  参考文献：
  名称：

  Anisimova, N. A.; Kramarova, E. P.; Belavin, I. Yu., Journal of general chemistry of the USSR, 1986, vol. 56, # 8, p. 1631 - 1638

  摘要：

  DOI：

文献信息

• Manufacture of haloalkyl lactams
  申请人：GAF Corporation

  公开号：US04792604A1

  公开（公告）日：1988-12-20

  A process for the manufacture of haloalkyl lactams having the formula ##STR1## wherein n is an integer having a value of from 1 to 3; m is an integer having a value of 1 or 2 and X is chlorine or bromine in the absence of an inert solvent by reacting a hydroxyalkyl lactam of the formula ##STR2## with a thionyl chloride or bromide in the liquid phase under anhydrous conditions, vaporizing and removing any excess thionyl halide along with SO.sub.2 by-product from the liquid reaction mixture under vacuum followed by vacuum distillation of the remaining liquid product mixture at a temperature below its decomposition and recovering said product. The product of this process can be obtained in greater than 90% yield and 99% purity.

  一种制备具有公式## STR1 ##的卤代烷基内酰胺的方法，其中n是1到3的整数；m是1或2的整数，X为氯或溴，在无惰性溶剂的情况下，通过将公式## STR2 ##的羟基烷基内酰胺与氯化亚砜或溴化亚砜在无水条件下在液相中反应，蒸发并去除任何过量的亚砜卤化物和SO.sub.2副产物，然后在真空下对剩余的液体产物混合物进行真空蒸馏，温度低于其分解温度，并回收所述产品。该过程的产物可以获得大于90％的产量和99％的纯度。
• A straightforward synthesis of methylenebisamides from amides and DMSO with a substoichiometric amount of (COCl)2
  作者：Hao Wang、Sen Liang、Yutong Wang、Shuai Peng、Yongguo Liu、Baoguo Sun、Hongyu Tian、Ning Li

  DOI：10.1016/j.molstruc.2022.133184

  日期：2022.9

  The preparation of methylenebisamides has been achieved by the reaction of amides with dimethyl sulfoxide (DMSO) in the presence of a substoichiometric amount of (COCl)2 in toluene at reflux. Various amides, including aliphatic and aryl amides, lactams, and carbamates, can be converted to the corresponding methylenebisamides in good to high yields. It is proposed that HCHO generated in situ from the

  亚甲基双酰胺的制备已通过酰胺与二甲亚砜 (DMSO) 在甲苯中亚化学计量的 (COCl) 2存在下回流反应来实现。各种酰胺，包括脂肪族和芳基酰胺、内酰胺和氨基甲酸酯，可以以良好至高产率转化为相应的亚甲基双酰胺。建议由 (COCl) 2催化的 DMSO 分解原位生成的 HCHO与酰胺反应生成双酰胺，该双酰胺由 DMSO 分解中产生的质子促进，无需任何额外的催化剂。与 DMSO- d6的反应也以高产率产生相应的亚甲基双酰胺-d2 。
• Cosmetic composition
  申请人：UNILEVER PLC

  公开号：EP0277428A2

  公开（公告）日：1988-08-10

  A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a first chemical inhibitor chosen from proteoglycanase inhibitors, glycosaminoglycanase inhibitors, glycosaminoglycan chain cellular uptake inhibitors or mixtures thereof; and (ii) a cosmetically acceptable vehicle for the chemical inhibitor; provided that when the first chemical inhibitor is a weak inhibitor, such that a 1mM aqueous solution of the inhibitor reduces proteoglycanase activity, glycosaminoglycanase activity or cellular uptake of glycosaminoglycan chains, by from 5 to 50%, in accordance with at least one of the assay tests as herein described, then there is also present in the composition a second chemical inhibitor and/or an activity enhancer. When minoxidil is the sole chemical inhibitor, then the activity enhancer is a penetration enhancer chosen from a limited number of materials, including certain esters and cationic polymers. The total amount of chemical inhibitor present in the composition is sufficient to increase hair growth in the rat, when said composition is applied topically thereto, by at least 10% more than that obtainable using a control composition from which the said inhibitors have been omitted.

  一种适用于哺乳动物皮肤或毛发局部使用的组合物，可诱导、保持或增加毛发生长，该组合物包括 (i) 第一种化学抑制剂，选自蛋白聚糖酶抑制剂、糖胺聚糖酶抑制剂、糖胺聚糖链细胞摄取抑制剂或其混合物；以及 (ii) 化学抑制剂的美容上可接受的载体；条件是当第一种化学抑制剂是一种弱抑制剂，如根据本文所述的至少一种测定试验，该抑制剂的 1mM 水溶液可降低蛋白多糖酶活性、糖胺聚糖酶活性或糖胺聚糖链的细胞摄取量 5%至 50%，则组合物中还含有第二种化学抑制剂和/或活性增强剂。当米诺地尔是唯一的化学抑制剂时，活性增强剂是从有限的几种材料中选择的渗透增强剂，包括某些酯类和阳离子聚合物。 当对大鼠局部施用所述组合物时，组合物中的化学抑制剂总量足以使大鼠的毛发生长量比使用省略了所述抑制剂的对照组合物时至少增加 10%。
• Poly(arlene sulfide/sulfone) processing properties improvement method
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0486823A2

  公开（公告）日：1992-05-27

  A method of improving the processing properties such as melt stability of poly(arylene sulfide/sulfone) is provided. The polymer is heated with a polar organic solvent, water and optionally, an alkali metal or alkaline earth metal carboxylate, to a temperature and for a time to dissolve the polymer whereupon the resulting solution is quenched with additional polar organic solvent, water and an alkali metal or alkaline earth metal carboxylate if not present in the original solution to cause a phase separation. The resultant mixture is cooled, and particulate poly(arylene sulfide/sulfone) having improved processing properties is recovered.

  本发明提供了一种改善聚（芳基烯硫醚/砜）熔融稳定性等加工性能的方法。将聚合物与极性有机溶剂、水以及碱金属或碱土金属羧酸盐一起加热到一定温度和时间，使聚合物溶解，然后用额外的极性有机溶剂、水以及碱金属或碱土金属羧酸盐（如果原溶液中不存在）骤冷所得到的溶液，以导致相分离。冷却得到的混合物，回收具有更好加工性能的微粒聚（芳基砜/砜）。
• Metal carbonate initiator and method for polymerizing isocyanates using the same
  申请人：Gwangju Institute of Science and Technology (GIST)

  公开号：EP1882710A1

  公开（公告）日：2008-01-30

  Disclosed herein is a metal carbonate initiator for polymerizing isocyanates and a method for polymerizing isocyanates by anionic polymerization using the same, in which the initiator forms a cluster upon the initiation and protects stability of terminal anions at the end of the chain to cause controlled polymerization, thus preventing depolymerizaton and improving reaction time and efficiency without the use of a separate additive.

  本文公开了一种用于聚合异氰酸酯的金属碳酸盐引发剂，以及使用该引发剂通过阴离子聚合法聚合异氰酸酯的方法，其中引发剂在引发时形成一个簇，并保护链末端末端阴离子的稳定性，使聚合受控，从而防止解聚，并提高反应时间和效率，而无需使用单独的添加剂。