3-ethyl-2-(5H)-furanone | 40029-70-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 3-ethyl-2-(5H)-furanone
• 英文别名: 3-ethyl-2(5H)-furanone；3-ethyl-5H-furan-2-one；α-Ethyl-Δ^α,β-butenolid；3-Ethylfuran-2(5H)-one；4-ethyl-2H-furan-5-one
• CAS: 40029-70-7
• 化学式: C₆H₈O₂
• 分子量: 112.128
• InChiKey: LYXHBPXYBNIGIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-甲基嘧啶 、 3-ethyl-2-(5H)-furanone 生成 3-Ethyldihydro-4-(4-pyrimidinylmethyl)-2(3H)-furanone
  参考文献：
  名称：

  毛果芸香碱某些结构类似物的合成及其胆碱能活性。

  摘要：

  DOI：

  10.1021/jm00261a017
• 作为产物：
  描述：

  3-ethyl-3-phenylsulfanyldihydrofuran-2-one 在 间氯过氧苯甲酸 作用下， 以 四氯化碳 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 3-ethyl-2-(5H)-furanone
  参考文献：
  名称：

  N-Phthaloylglycine-Derived Strigol Analogues. Influence of the D-Ring on Seed Germination Activity of the Parasitic Weeds Striga hermonthica and Orobanche crenata

  摘要：

  Several strigol analogues with modifications in the D-ring were synthesized and assayed for germination stimulatory activity of seeds of Striga hermonthica and Orobanche crenata. All of these D-ring analogues are derived from N-phthaloylglycine as the common ABC-fragment. It was concluded that the correct structure of the 2(5H)-furanone D-ring is essential to retain full biological activity.

  DOI：

  10.1021/jf9604652

文献信息

• Cyclopropanation of (E)-Dehydroaspartic Acid Esters with Furan Derivatives: The Synthesis of Highly Functionalized α-2,3-Methanoamino Acid Esters
  作者：Tetsuro Shinada、Atsushi Manabe、Ryotaro Matsumoto

  DOI：10.1055/s-0034-1380812

  日期：——

  Highly functionalized α-2,3-methanoamino acid esters were prepared by the cyclopropanation of dehydroaspartic acid esters with 2-methoxyfuran or 2-siloxyfuran derivatives. These reactions proceed smoothly in the absence of any catalysts, bases, additives, or solvents.

  通过脱氢天冬氨酸酯与 2-甲氧基呋喃或 2-甲硅烷氧基呋喃衍生物的环丙烷化反应制备了高度官能化的 α-2,3- 甲氨基酸酯。这些反应在没有任何催化剂、碱、添加剂或溶剂的情况下顺利进行。
• Selenophene and Selenazole Carboxylic Acid Derivatives
  申请人：Graul Regina

  公开号：US20110275683A1

  公开（公告）日：2011-11-10

  Derivatives of selenophene and selenazole heterocycles are disclosed. The compounds are useful as inhibitors of D-amino acid oxidase (DAO) and in the treatment of neurodegenerative and psychiatric diseases and disorders.

  本发明揭示了硒杂苯和硒杂唑杂环的衍生物。这些化合物可用作D-氨基酸氧化酶（DAO）的抑制剂，并用于治疗神经退行性和精神疾病和障碍。
• NOVEL ADENINE COMPOUND AND USE THEREOF
  申请人：ISOBE Yoshiaki

  公开号：US20120178743A1

  公开（公告）日：2012-07-12

  An antiallergic agent for topical administration containing an adenine compound of general formula (1): [wherein ring A represents a 6 to 10 membered, mono or bicyclic, aromatic hydrocarbon or a 5 to 10 membered, mono or bicyclic, aromatic heterocycle containing one to three heteroatoms selected among 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and 0 or 1 sulfur atom; n is an integer of 0 to 2; m is an integer of 0 to 2; R represents halogeno, (un)substituted alkyl, etc.; X 1 represents oxygen, sulfur, NR 1 (R 1 represents hydrogen or alkyl), or a single bond; Y 1 represents a single bond, alkylene, etc.; Y 2 represents a single bond, alkylene, etc.; Z represents alkylene; and at least one of Q 1 and Q 2 represents —COOR 10 (wherein R 10 represents (un)substituted alkyl, etc.), etc.] or a pharmaceutically acceptable salt of the compound.

  一种用于局部给药的抗过敏剂，包含一种通式（1）的腺嘌呤化合物：[其中环A代表一个6到10个成员的单环或双环芳香烃或一个5到10个成员的单环或双环芳香杂环，其中包含1到3个杂原子，选择自0到2个氮原子，0或1个氧原子和0或1个硫原子；n是0到2的整数；m是0到2的整数；R代表卤素，（未）取代的烷基等；X1代表氧，硫，NR1（R1代表氢或烷基）或单键；Y1代表单键，亚烷基等；Y2代表单键，亚烷基等；Z代表亚烷基；且Q1和Q2中的至少一个代表—COOR10（其中R10代表（未）取代的烷基等），等的药学上可接受的盐。
• ADENINE COMPOUND AND USE THEREOF
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1550662B1

  公开（公告）日：2012-07-04
• Ruthenium-Catalyzed Cyclocarbonylation of Allenyl Alcohols and Amines:  Selective Synthesis of Lactones and Lactams
  作者：Eiji Yoneda、Shi-Wei Zhang、Da-Yang Zhou、Kiyotaka Onitsuka、Shigetoshi Takahashi

  DOI：10.1021/jo0350615

  日期：2003.10.1

  Allenyl alcohols such as 4-hydroxybuta-1,2-dienes and 5-hydroxypenta-1,2-dienes having a variety of substituents undergo cyclocarbonylation in the presence of a ruthenium catalyst under mild conditions selectively to give five- and six-membered lactones in a high yield with 100% atom economy. 5-Aminopenta-1,2-dines are also cyclocarbonylated to give gamma-lactams. A possible carbonylation mechanism involving a ruthenium cluster intermediate is proposed on the basis of experimental results.