[EN] COMBINATION TREATMENT OF CANCER TARGETING ENERGY METABOLISM AND INTRACELLULAR PH<br/>[FR] TRAITEMENT COMBINÉ CONTRE LE CANCER CIBLANT LE MÉTABOLISME ÉNERGÉTIQUE ET LE PH INTRACELLULAIRE
申请人:DEUTSCHES KREBSFORSCH
公开号:WO2020234454A1
公开(公告)日:2020-11-26
The present invention relates to a compound causing a decrease of intracellular pH for use in treatment of cancer with an inhibitor of mitochondrial respiration and a proton ionophore; to a proton ionophore for use in treatment of cancer with an inhibitor of mitochondrial respiration and a compound causing a decrease of intracellular pH; and to an inhibitor of mitochondrial respiration for use in treatment of cancer with a proton ionophore and a compound causing a decrease of intracellular pH. The present invention also relates to a combined preparation for simultaneous, separate or sequential use comprising (i) a compound causing a decrease of intracellular pH, (ii) an inhibitor of mitochondrial respiration, and (iii) a proton ionophore, and to a method for determining whether a subject suffering from cancer is susceptible to a combined treatment comprising administration of a compound causing a decrease of intracellular pH, an inhibitor of mitochondrial respiration, and a proton ionophore related thereto.