1,1'-[Decane-1,10-diylbis(oxymethylene)]dibenzene | 165960-94-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1'-[Decane-1,10-diylbis(oxymethylene)]dibenzene
• 英文别名: 10-phenylmethoxydecoxymethylbenzene
• CAS: 165960-94-1
• 化学式: C₂₄H₃₄O₂
• 分子量: 354.533
• InChiKey: QBVNEVRTMSQRIT-UHFFFAOYSA-N

物化性质

• 沸点：
  448.7±20.0 °C(Predicted)
• 密度：
  0.982±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  26
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苄基-5-溴戊醚 在 magnesium 、 1,2-二溴乙烷 作用下， 以 乙醚 为溶剂， 生成 1,1'-[Decane-1,10-diylbis(oxymethylene)]dibenzene
  参考文献：
  名称：

  结核分枝杆菌中 关键酶的活性位点可塑性†

  摘要：

  3-脱氧d -阿拉伯-heptulosonate -7-磷酸合酶中的一个重要生物合成酶的结核分枝杆菌与可能的药物靶标。我们描述了具有不同链长的抑制剂的合成，评估和对接，从而提供了对抑制剂结合活性位点可塑性的了解。

  DOI：

  10.1039/c3ra00037k

文献信息

• Highly selective silver(I) oxide mediated monoprotection of symmetrical diols
  作者：Abderrahim Bouzide、Gilles Sauvé

  DOI：10.1016/s0040-4039(97)01328-2

  日期：1997.8

  Treatment of symmetrical diol with Ag2O and alkyl halide gave the monoprotected derivative in good to excellent yield.

  用Ag 2 O和烷基卤处理对称的二醇以良好至优异的产率得到单保护的衍生物。
• Monobenzylation Of 1,<i>n</i>-Diols via Dibutylstannylene Intermediates
  作者：Eugene A. Mash、Liza T. A. Kantor、Stephen C. Waller

  DOI：10.1080/00397919708006052

  日期：1997.2

  Symmetrical primary 1,n-diols, HO(CH2)(n)OH, of any chain length from n = 2-10, can be selectively monobenzylated via sequential treatment with dibutyltin oxide and benzyl bromide.
• Edelson-Averbukh, Marina; Etinger, Alexander; Mandelbaum, Asher, Journal of the Chemical Society. Perkin Transactions 2 (2001), 1999, # 6, p. 1095 - 1105
  作者：Edelson-Averbukh, Marina、Etinger, Alexander、Mandelbaum, Asher

  DOI：——

  日期：——
• Total synthesis of sulfobacin A (flavocristamide B)
  作者：Naoko Irako、Takayuki Shioiri

  DOI：10.1016/s0040-4039(98)01177-0

  日期：1998.8

  Sulfobacin A (1), a novel von Willebrand factor receptor antagonist isolated from the culture broth of Chryseobacterium sp. NR 2993, was efficiently synthesized for the first time. (C) 1998 Elsevier Science Ltd. All rights reserved.
• The First Total Synthesis of (+)-Bullatacin, a Potent Antitumor Annonaceous Acetogenin, and (+)-(15,24)-bis-epi-Bullatacin
  作者：Hiroyuki Naito、Eiji Kawahara、Katsunori Maruta、Minoru Maeda、Shigeki Sasaki

  DOI：10.1021/jo00119a019

  日期：1995.7

  This paper reports the first total synthesis of the natural product (+)-bullatacin (1), a representative of potent antitumor Annonaceous acetogenins, as well as a stereoisomer (+)-(15,24)-bisepi-bullatacin (2). In this synthesis, a new, efficient method has been developed to introduce the gamma-lactone into the bistetrahydrofuran skeleton through in situ alkylation of epoxide 4 by the alpha-sulfonyl carbanion of phenyl sulfone 5. The methylated gamma-lactone was successfully synthesized by a sequence of reactions comprising an aldol reaction, an acidic lactonization, and elimination under mild, basic condition.