3-(2-Benzyloxycarbonylhydrazino)-1-carboxymethyl-6-methylpyrazinone | 369368-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-Benzyloxycarbonylhydrazino)-1-carboxymethyl-6-methylpyrazinone
• 英文别名: 2-[6-methyl-2-oxo-3-(2-phenylmethoxycarbonylhydrazinyl)pyrazin-1-yl]acetic acid
• CAS: 369368-49-0
• 化学式: C₁₅H₁₆N₄O₅
• 分子量: 332.316
• InChiKey: DQXCTACKFFXQAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  120
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-Carboxymethyl-3-hydrazino-6-methylpyrazinone 、 氯甲酸苯酯 在 碳酸氢钠 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以90%的产率得到3-(2-Benzyloxycarbonylhydrazino)-1-carboxymethyl-6-methylpyrazinone
  参考文献：
  名称：

  Substituted hydrazinyl heteroaromatic inhibitors of thrombin

  摘要：

  本发明的化合物作为凝血酶抑制剂具有活性，并可用于治疗哺乳动物中由异常血栓形成特征的疾病状态，其具有以下结构：如本文所述。

  公开号：

  US06506760B1

文献信息

• US6506761B1
  申请人：——

  公开号：US6506761B1

  公开（公告）日：2003-01-14
• US6506760B1
  申请人：——

  公开号：US6506760B1

  公开（公告）日：2003-01-14
• [EN] SUBSTITUTED HYDRAZINYL HETEROAROMATIC INHIBITORS OF THROMBIN<br/>[FR] INHIBITEURS HETEROAROMATIQUES HYDRAZINYL-SUBSTITUES DE LA THROMBINE
  申请人：CORVAS INT INC

  公开号：WO2001079193A2

  公开（公告）日：2001-10-25

  The present invention provides compounds which have a hydrazinyl linkage at P4-P3, and featuring at P1 1) a bicyclic ring, 2) a cyclic group substituted with an amidine derivative or an amino derivative, or 3) a six-membered heterocyclic ring having two ring nitrogens and the remainder of the ring atoms carbon atoms. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.
• Substituted hydrazinyl heteroaromatic inhibitors of thrombin
  申请人：Corvas International, Inc.

  公开号：US06506760B1

  公开（公告）日：2003-01-14

  Compounds of the invention are active as inhibitors of Thrombin and are useful in treating disease states in mammals which are characterized by abnormal thrombosis and have the following structure: as described herein.

  本发明的化合物作为凝血酶抑制剂具有活性，并可用于治疗哺乳动物中由异常血栓形成特征的疾病状态，其具有以下结构：如本文所述。