benzylphosphonic acid-mono-phenethyl ester | 1353003-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzylphosphonic acid-mono-phenethyl ester
• 英文别名: Benzyl(2-phenylethoxy)phosphinic acid；benzyl(2-phenylethoxy)phosphinic acid
• CAS: 1353003-11-8
• 化学式: C₁₅H₁₇O₃P
• 分子量: 276.272
• InChiKey: GCFBPEVLDFEMRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙醇 、 苄基磷酸 在 吡啶 、 三氯乙腈 作用下， 反应 0.25h， 以73%的产率得到benzylphosphonic acid-mono-phenethyl ester
  参考文献：
  名称：

  One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl3CN–pyridine coupling conditions

  摘要：

  Simple and convenient one-pot synthesis of a phosphorus-oxygen bond in phosphate diesters and phosphonate monoesters using trichloroacetonitrile as an activating agent and pyridine as a solvent under microwave irradiation conditions was described. This method is useful for the preparation of various biologically interesting glycophospholipids and also phosphate diesters or phosphonate monoesters containing diverse moieties such as alkyl, prenyl, and benzyl substituents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.032

文献信息

• One-pot synthesis of phosphate diesters and phosphonate monoesters via a combination of microwave-CCl3CN–pyridine coupling conditions
  作者：Hao-Wei Shih、Kuo-Ting Chen、Wei-Chieh Cheng

  DOI：10.1016/j.tetlet.2011.11.032

  日期：2012.1

  Simple and convenient one-pot synthesis of a phosphorus-oxygen bond in phosphate diesters and phosphonate monoesters using trichloroacetonitrile as an activating agent and pyridine as a solvent under microwave irradiation conditions was described. This method is useful for the preparation of various biologically interesting glycophospholipids and also phosphate diesters or phosphonate monoesters containing diverse moieties such as alkyl, prenyl, and benzyl substituents. (C) 2011 Elsevier Ltd. All rights reserved.