α-ethoxy-m-xylene | 64988-09-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: α-ethoxy-m-xylene
• 英文别名: ethyl-(3-methyl-benzyl)-ether；α-Aethoxy-m-xylol；3-Methyl-1-aethoxymethyl-benzol；Aethyl-(3-methyl-benzyl)-aether；1¹-Aethoxy-1.3-dimethyl-benzol；Aethyl-m-tolubenzyl-aether；(3-Methylphenyl) methanol, ethyl ether；1-(ethoxymethyl)-3-methylbenzene
• CAS: 64988-09-6
• 化学式: C₁₀H₁₄O
• 分子量: 150.221
• InChiKey: RZUNTOOULBXNEN-UHFFFAOYSA-N

物化性质

• 沸点：
  202-203 °C
• 密度：
  0.9487 g/cm3(Temp: 13.95 °C)
• 保留指数：
  1165

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-甲基苄溴 在 吡啶 、 mercury(II) fluoride 、 氯仿 作用下， 生成 α-ethoxy-m-xylene
  参考文献：
  名称：

  The Preparation and Properties of Some Substituted Benzyl Fluorides¹

  摘要：

  DOI：

  10.1021/ja01187a003

文献信息

• Selective cross coupling via oxovanadium(V)-induced oxidative desilylation of benzylic silanes
  作者：Toshikazu Hirao、Takashi Fujii、Yoshiki Ohshiro

  DOI：10.1016/0040-4039(94)80034-0

  日期：1994.10

  Benzylic silanes bearing an electron-donating group at the ortho- or para-position underwent the oxovanadium(V)-induced one-electron oxidative desilylation due to low ionization potential, which was applied to the intermolecular regioselective coupling with allylic silanes or silyl enol ether.

  在邻位或对位带有给电子基团的苯甲硅烷由于低电离势而经历了氧钒（V）诱导的单电子氧化甲硅烷基化反应，该技术被用于与烯丙基硅烷或甲硅烷基烯醇醚的分子间区域选择性偶联。
• AGENT FOR CONTROLLING NOXIOUS ARTHROPODS
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20180168159A1

  公开（公告）日：2018-06-21

  An agent for controlling noxious arthropods has an exceptional noxious arthropod controlling effect, said agent containing an amide compound represented by Formula (I) and an inactive carrier. In formula (I), R 2 represents a C1-C3 chain hydrocarbon group, etc., R 5 and R 6 represent a hydrogen atom, etc., R 9 represents a C1-C4 alkyl group, etc., R 10 represents a C1-C4 alkyl group or hydrogen atom, etc., R 11 and R 12 each independently represent a C1-C4 alkyl group, etc., and Y represents a single bond, an oxygen atom, or S(O) u ; when Y is a single bond, m represents 0, and Q represents a C1-C8 chain hydrocarbon group, etc.; and when Y is an oxygen atom or S(O) u , m represents any integer of 0 to 7, Q represents a C1-C8 chain hydrocarbon group, etc., a and b represent 0, 1, 2, or 3 (the sum of a and b representing any integer of 1 to 6), and u represents 0, 1, or 2.

  一种用于控制有害节肢动物的剂具有出色的有害节肢动物控制效果，所述剂包含由式（I）表示的酰胺化合物和一种无活性载体。在式（I）中，R2代表一个C1-C3链烃基，等等，R5和R6代表一个氢原子，等等，R9代表一个C1-C4烷基，等等，R10代表一个C1-C4烷基或氢原子，等等，R11和R12各自独立地代表一个C1-C4烷基，等等，Y代表一个单键，一个氧原子或S(O)u；当Y是一个单键时，m表示0，Q表示一个C1-C8链烃基，等等；当Y是一个氧原子或S(O)u时，m表示0到7的任意整数，Q表示一个C1-C8链烃基，等等，a和b表示0、1、2或3（a和b的总和表示1到6的任意整数），u表示0、1或2。
• PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DISEASES ASSOCIATED WITH DECREASE IN BONE MASS COMPRISING EP4 AGONIST AS ACTIVE INGREDIENT
  申请人：MARUYAMA Toru

  公开号：US20100010222A1

  公开（公告）日：2010-01-14

  A pharmaceutical composition for topical administration for prevention and/or treatment of diseases associated with decrease in bone mass comprising an EP 4 agonist as an active ingredient. An EP 4 agonist, in which includes a compound possessing prostaglandin skeleton as a representative, possesses promoting action on bone formation, so it is useful for prevention and/or treatment of diseases associated with decrease in bone mass (bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone grafting).

  一种用于局部治疗预防和/或治疗与骨量减少相关疾病的药物组合物，包括EP4激动剂作为活性成分。EP4激动剂，其中包括具有前列腺素骨架的化合物作为代表，具有促进骨形成的作用，因此对于预防和/或治疗与骨量减少相关的疾病（如原发性骨质疏松症、继发性骨质疏松症、骨癌转移、高钙血症、帕吉特病、骨丢失和骨坏死、术后骨生成、骨移植替代疗法）非常有用。
• Isoprenyl Compounds and Methods Thereof
  申请人：Stock Jeffry B.

  公开号：US20100184768A1

  公开（公告）日：2010-07-22

  Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

  除其他事项外，本发明提供了新型异戊二烯基化合物，能够有效调节炎症反应，并提供包含这些异戊二烯基化合物的药物、化妆品、化妆品和局部组合物。本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或症状。本发明的促炎化合物可用于治疗或预防与抑制炎症反应相关的疾病或症状。因此，本发明还提供了用于治疗或预防与炎症相关的疾病或症状以及用于治疗或预防与抑制炎症反应相关的疾病或症状的方法。
• Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0268878A2

  公开（公告）日：1988-06-01

  Disclosed herein are salicylic acid copolymers having a weight average molecular weight of 500 10,000 and obtained (a) by condensing salicylic acid (i) with a benzyl alcohol (ii) and/or benzyl ether (iii) or a benzyl halide (iv) in the presence of an acid catalyst or (b) by reacting a co-condensation resin of (i) and (ii) and/or (iii) with (iv) or (c) by reacting a co-condensation resin of (i) and (ii) and/or (iii) or (iv) with a styrene derivative in the presence of an acid catalyst; multivalent metal salts of the salicylic acid copolymers; color-developing agents comprising the multivalent metal salts; and color-developing sheets suited for pressure-sensitive copying paper and comprising the color-developing agents. Their production processes are also disclosed.

  本文公开了水杨酸共聚物，其重量平均分子量为 500 10、000 的水杨酸共聚物；(a)在酸催化剂存在下，将水杨酸(i)与苄醇(ii)和/或苄醚(iii)或苄基卤化物(iv)缩合而得，或(b)将(i)和(ii)和/或(iii)的共缩合树脂与(iv)反应而得，或(c)在酸催化剂存在下，将(i)和(ii)和/或(iii)或(iv)的共缩合树脂与苯乙烯衍生物反应而得；水杨酸共聚物的多价金属盐；由多价金属盐组成的显色剂；以及由显色剂组成的适用于压敏复印纸的显色薄片。此外，还公开了它们的生产工艺。