4-Benzyloxy-2-ethoxy-pyrido[2,3-d]pyrimidine | 864667-17-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 4-Benzyloxy-2-ethoxy-pyrido[2,3-d]pyrimidine
• 英文别名: 2-Ethoxy-4-phenylmethoxypyrido[2,3-d]pyrimidine；2-ethoxy-4-phenylmethoxypyrido[2,3-d]pyrimidine
• CAS: 864667-17-4
• 化学式: C₁₆H₁₅N₃O₂
• 分子量: 281.314
• InChiKey: OQQXLZVWOHXTRM-UHFFFAOYSA-N

物化性质

• 沸点：
  467.0±53.0 °C(Predicted)
• 密度：
  1.231±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  57.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-Benzyloxy-2-ethoxy-pyrido[2,3-d]pyrimidine 、 乙醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以79%的产率得到2,4-diethoxy-pyrido[2,3-d]pyrimidine
  参考文献：
  名称：

  Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions

  摘要：

  Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.141
• 作为产物：
  描述：

  2-氨基烟酸 在 sodium hydride 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 生成 4-Benzyloxy-2-ethoxy-pyrido[2,3-d]pyrimidine
  参考文献：
  名称：

  Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions

  摘要：

  Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.06.141

文献信息

• Selective bifunctionalization of pyrido[2,3-d]pyrimidines in positions 2 and 4 by SNAr and palladium-catalyzed coupling reactions
  作者：G. Lavecchia、S. Berteina-Raboin、G. Guillaumet

  DOI：10.1016/j.tetlet.2005.06.141

  日期：2005.8

  Selective disubstitution of 2,4-dichloropyrido[2,3-d]pyrimidine with various nucleophiles was investigated. Suzuki and Stille cross-coupling reactions on monosubstituted compound 4-tert-butylamino-2-chloro-pyrido[2,3-d]pyrimidine were performed in high yields. (c) 2005 Elsevier Ltd. All rights reserved.