S-[(2-Methyl-1,2-oxazolidin-5-yl)methyl] ethanethioate | 404572-56-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: S-[(2-Methyl-1,2-oxazolidin-5-yl)methyl] ethanethioate
• CAS: 404572-56-1
• 化学式: C₇H₁₃NO₂S
• 分子量: 175.25
• InChiKey: CHNOLHRIRKZGOE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  54.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Novel thio derivatives of sordarin as antifungal agents
  申请人：——

  公开号：US20020035073A1

  公开（公告）日：2002-03-21

  The present invention relates to antifungal compounds having the structural formula: 1 and pharmaceutically acceptable salts, solvates and prodrugs thereof. The present invention further relates to pharmaceutical compositions containing said compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof, for use in the treatment of a fungal infection in an animal host.

  本发明涉及具有结构式的抗真菌化合物： 1 及其药学上可接受的盐、溶液剂和原药。本发明还涉及含有所述化合物或其药学上可接受的盐、溶液剂或原药的药物组合物，用于治疗动物宿主的真菌感染。
• US6436930B1
  申请人：——

  公开号：US6436930B1

  公开（公告）日：2002-08-20
• [EN] NOVEL THIO DERIVATIVES OF SORDARIN AS ANTIFUNGAL AGENTS<br/>[FR] NOUVEAUX THIO-DERIVES DE SORDARINE COMME AGENTS ANTIFONGIQUES
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2002022567A1

  公开（公告）日：2002-03-21

  The present invention relates to antifungal compounds having the structural formula (I) in which X is S, SO, SO2, or S(O)(NR1) and the other variables are as defined in the claims; and pharmaceutically acceptable salts, solvates and prodrugs thereof. The present invention further relates to pharmaceutical compositions containing said compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof, for use in the treatment of a fungal infection in an animal host.