2-Hydroxy-4,5,6,7-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione | 124423-42-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-Hydroxy-4,5,6,7-tetrahydro-1H-4,7-methanoisoindole-1,3(2H)-dione
• 英文别名: 4-hydroxy-4-azatricyclo[5.2.1.02,6]dec-2(6)-ene-3,5-dione
• CAS: 124423-42-3
• 化学式: C₉H₉NO₃
• 分子量: 179.17
• InChiKey: GBZRHYUEHYCWAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Crosslinkable polysaccharide derivative, process for producing the same, crosslinkable polysaccharide composition, and medical treatment material
  申请人：Abe Yoshihiko

  公开号：US20060178339A1

  公开（公告）日：2006-08-10

  A crosslinkable polysaccharide derivative which has in the side chain of polysaccharide at least one active ester group reactive with an active hydrogen-containing group and which forms a crosslinked product through covalent bond between the active ester group and the active hydrogen-containing group upon contact with alkaline water. A composition and a medical treatment material containing the crosslinkable polysaccharide derivative. The crosslinkable polysaccharide derivative produces a high bond strength that meets clinical requirements. It avoids the risk of infection because it is based on a material which is not derived from living organisms. It in itself and its decomposition products have a low level of toxicity because it is formed from a synthetic material. It is biodegradable and bioabsorbable. It can be prepared readily and simply without requiring special apparatus at the time of use.

  一种可交联的多糖衍生物，在多糖的侧链中至少有一个与含有活性氢基团的活性酯基团反应的活性酯基团，且在与碱性水接触时通过活性酯基团与含有活性氢基团之间的共价键形成交联产物。包含可交联多糖衍生物的组合物和医疗治疗材料。可交联的多糖衍生物产生符合临床要求的高结合强度。它避免了感染风险，因为它基于非生物来源的材料。本身及其分解产物具有低毒性水平，因为它是由合成材料形成的。它具有生物降解和生物吸收性。在使用时可以轻松简便地准备，无需特殊设备。
• HIV protease inhibitors
  申请人：JAPAN ENERGY CORPORATION

  公开号：EP0490667A2

  公开（公告）日：1992-06-17

  Human immunodeficiency virus (HIV) protease inhibitors comprising a compound represented by the following general formula or pharmaceutically acceptable salt thereof: The inhibitors are effective for treating a patient suffering from AIDS and AIDS related diseases.

  人类免疫缺陷病毒（HIV）蛋白酶抑制剂，包括由以下通式代表的化合物或其药学上可接受的盐： 这些抑制剂可有效治疗艾滋病和艾滋病相关疾病患者。
• CROSSLINKABLE POLYSACCHARIDE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, CROSSLINKABLE POLYSACCHARIDE COMPOSITION AND MEDICAL TREATMENT MATERIAL
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP1595892A1

  公开（公告）日：2005-11-16

  A crosslinkable polysaccharide derivative which has in the side chain of polysaccharide at least one active ester group reactive with an active hydrogen-containing group and which forms a crosslinked product through covalent bond between the active ester group and the active hydrogen-containing group upon contact with alkaline water. A composition and a medical treatment material containing the crosslinkable polysaccharide derivative. Said crosslinkable polysaccharide derivative produces a high bond strength that meets clinical requirements. It avoids the risk of infection because it is based on a material which is not derived from living organisms. It in itself and its decomposition products have a low level of toxicity because it is formed from a synthetic material. It is biodegradable and bioabsorbable. It can be prepared readily and simply without requiring special apparatus at the time of use.

  一种可交联多糖衍生物，其多糖侧链中至少有一个活性酯基与活性含氢基反应，与碱性水接触后，通过活性酯基与活性含氢基之间的共价键形成交联产物。一种含有可交联多糖衍生物的组合物和医疗材料。所述可交联多糖衍生物可产生符合临床要求的高粘合强度。它避免了感染的风险，因为它是基于一种并非来自生物体的材料。由于它是由合成材料制成的，因此其本身及其分解产物的毒性较低。可生物降解和生物吸收。使用时不需要特殊的仪器，即可轻松简单地制备。
• IMMUNOCHROMATOGRAPHIC TEST PIECE
  申请人：Toyobo Co., Ltd.

  公开号：EP3364189A1

  公开（公告）日：2018-08-22

  [Problem] To provide an immunochromatographic test piece containing a control line detection reagent that is not affected by the concentration of an analyte to be detected. [Means for Solution] An immunochromatographic test piece for quantifying an analyte in a biological sample, the immunochromatographic test piece comprising (a) a conjugation pad impregnated with a detection reagent that specifically binds to the analyte, and a control line detection reagent; and (b) a porous membrane pad on which an antibody for capturing the analyte is immobilized upstream, and an antibody for capturing specifically the control line detection reagent is immobilized downstream.

  [问题]提供一种免疫层析试片，其中含有不受待检测分析物浓度影响的控制线检测试剂。[解决方法]一种用于定量生物样品中分析物的免疫层析试片，该免疫层析试片包括：(a) 一个浸渍有与分析物特异性结合的检测试剂和控制线检测试剂的连接垫；以及 (b) 一个多孔膜垫，在该多孔膜垫上，上游固定有用于捕获分析物的抗体，下游固定有用于特异性捕获控制线检测试剂的抗体。
• SUSTAINED-RELEASE TOPICALLY ADMINISTERED AGENT
  申请人：Terumo Kabushiki Kaisha

  公开号：EP3375456A1

  公开（公告）日：2018-09-19

  A sustained-release topically administered agent includes a compound having a pharmacological action, a crosslinking polysaccharide derivative having at least one active ester group, introduced into a side chain of a polysaccharide, which is capable of reacting with an active hydrogen-containing group, and being capable of forming a crosslinked substance by a covalent bond between the active ester group and the active hydrogen-containing group; and a pH adjuster for adjusting a pH condition suitable for forming a biodegradable gel containing the compound when the sustained-release topically administered agent is mixed. The sustained-release topically administered agent forms the biodegradable gel containing the compound when the sustained-release topically administered agent is mixed. The pH of the biodegradable gel is not less than five.

  一种局部给药的缓释制剂包括一种具有药理作用的化合物、一种交联多糖衍生物，该衍生物具有至少一个活性酯基，被引入到多糖的侧链中，能与活性含氢基团反应，并能通过活性酯基和活性含氢基团之间的共价键形成交联物质；pH调节剂，用于调节pH值，使其适合在混合缓释局部给药剂时形成含有该化合物的可生物降解凝胶。当混合缓释局部给药剂时，缓释局部给药剂形成含有化合物的可生物降解凝胶。可生物降解凝胶的 pH 值不低于 5。