Mectizan

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Mectizan
• 英文别名: (1R,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-6'-butan-2-yl-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one;(1R,5'S,6R,6'R,8R,10E,12S,13S,14E,16E,20R,21R,24S)-21,24-dihydroxy-12-[(2R,4S,5S,6S)-5-[(4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy-4-methoxy-6-methyloxan-2-yl]oxy-5',11,13,22-tetramethyl-6'-propan-2-ylspiro[3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene-6,2'-oxane]-2-one
• 化学式: C95H146O28
• 分子量: 1736.2
• InChiKey: SPBDXSGPUHCETR-VHJJIYNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.81
• 重原子数：
  123
• 可旋转键数：
  15
• 环数：
  14.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  340
• 氢给体数：
  6
• 氢受体数：
  28

ADMET

毒理性

• 在妊娠和哺乳期间的影响

哺乳期使用总结：有限的数据表明，伊维菌素在口服给药后不易排入乳汁中。婴儿摄入的量很小，预计不会对7天以上的哺乳婴儿产生任何不良反应。目前尚无关于伊维菌素在局部给药后排入乳汁的数据，但量应小于口服给药。避免涂抹在乳房区域，以免婴儿直接摄入药物。 哺乳婴儿的影响：截至修订日期，未找到相关已发表信息。 对哺乳和乳汁的影响：截至修订日期，未找到相关已发表信息。

◉ Summary of Use during Lactation:Limited data indicate that ivermectin is poorly excreted into breastmilk after oral administration. Amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants over 7 days of age. No data are available on ivermectin excretion into breastmilk after topical administration, but amounts should be less than after oral administration. Avoid application to the breast area where the infant might directly ingest the drug. ◉ Effects in Breastfed Infants:Relevant published information was not found as of the revision date. ◉ Effects on Lactation and Breastmilk:Relevant published information was not found as of the revision date.

来源:Drugs and Lactation Database (LactMed)