(2-Oxopyrrolidin-1-yl)methyl 2-methylprop-2-enoatato | 192825-71-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2-Oxopyrrolidin-1-yl)methyl 2-methylprop-2-enoatato
• 英文别名: (2-oxopyrrolidin-1-yl)methyl 2-methylprop-2-enoate
• CAS: 192825-71-1
• 化学式: C₉H₁₃NO₃
• 分子量: 183.2
• InChiKey: CYRKCTYDKNSRQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• MEMBRANE TYPE ARTIFICIAL LUNG AND PRODUCTION THEREOF
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0354959A1

  公开（公告）日：1990-02-21

  This invention relates to a membrane type artificial lung which performs gas exchange by use of a porous gas exchange membrane (2) having fine pores (3) as gas flow paths, and more particularly to a membrane type artificial lung wherein fine particles (4) are retained by the fine pores (3) of the porous gas exchange membrane (2) so as to reduce the cross-sectional area of the gas paths and a blood anticoagulant is held by the fine particles (4) or between the fine particles (4). This artificial lung is produced by the steps of assembling a membrane type artificial lung (1) housing therein a porous gas exchange membrane (2) having fine pores (3) as gas paths, causing a dispersion of the fine particles (4) to flow into the lung (1) so as to let the fine pores (3) retain the fine particles (4) and to reduce the cross-sectional area of the gas paths, removing the dispersion remaining inside the lung (1), causing a solution containing a blood anticoagulant to flow into the artificial lung, passing this solution through the fine pores (3) of the gas exchange film and depositinq the blood anticoaqulant to the fine particles (4).

  本发明涉及一种膜式人工肺，它通过使用具有细孔(3)作为气体流动路径的多孔气体交换膜(2)进行气体交换，更具体地说，涉及一种膜式人工肺，其中细颗粒(4)被多孔气体交换膜(2)的细孔(3)截留，以减小气体路径的横截面积，血液抗凝剂被细颗粒(4)截留或在细颗粒(4)之间截留。这种人工肺的制造步骤是：组装一个膜式人工肺（1），在其中容纳一个多孔气体交换膜（2），该膜具有细孔（3）作为气体通道，使细颗粒（4）的分散液流入肺（1），以便让细孔（3）保留细颗粒（4）并减小气体通道的横截面积、清除留在肺（1）内的分散液，使含有血液抗凝剂的溶液流入人工肺，使该溶液通过气体交换膜的细孔（3），并将血液抗凝剂沉积到细颗粒（4）上。
• NOVEL COPOLYMERS FORMED FROM THREE COMPONENTS AND INTRAOCULAR LENSES MADE THEREOF
  申请人：SANTEN PHARMACEUTICAL CO., LTD.

  公开号：EP0869138A1

  公开（公告）日：1998-10-07

  The invention relates to a foldable intraolcular lens material, characterized in that the material is composed of the following repeat units [I], [II] and [III], and it comprises 60 - 80 wt % of [I], 10 - 30 wt % of [II] and 5 - 20 wt % of [III], based on the total weight of 100%. In formula [I] R1 represents hydrogen atom or alkyl, R2 represents alkylene which can be substituted by hydroxyl group, in addition, the alkylene chain can contain oxygen atom also. In formula [II], R3 represents formula [IIa] [IIb] [IIc],in which R5, R6, R7and R8 represent hydrogen atom or alkyl respectively, m, n, p and q are integers from 1 to 4 or a single bond and R4 is hydrogen atom or alkyl. In formula [III] R9 is hydrogen atom or alkyl and R10 is alkyl.

  本发明涉及一种可折叠的分子内晶状体材料，其特征在于该材料由以下重复单元[I]、[II]和[III]组成，以100%的总重量为基准，[I]的重量百分比为60-80%，[II]的重量百分比为10-30%，[III]的重量百分比为5-20%。在式[I]中，R1 代表氢原子或烷基，R2 代表可被羟基取代的亚烷基，此外，亚烷基链还可包含氧原子。在式［II］中，R3 代表式［IIa］［IIb］［IIc］，其中 R5、R6、R7 和 R8 分别代表氢原子或烷基，m、n、p 和 q 是 1 至 4 的整数或单键，R4 是氢原子或烷基。在式 [III] 中，R9 是氢原子或烷基，R10 是烷基。
• FOUR COMPONENT COPOLYMER AND THE OCULAR LENS MADE THEREOF
  申请人：SANTEN PHARMACEUTICAL CO., LTD

  公开号：EP1026182A1

  公开（公告）日：2000-08-09

  This invention relates to a hydrophilic copolymer, which is suitable for the production of ocular lens such as intraocular lens or contact lens, particularly suitable for foldable intraocular lens, and also to the intraocular lens made thereof.

  本发明涉及一种亲水共聚物，它适用于生产眼内透镜或隐形眼镜等眼科晶状体，尤其适用于可折叠眼内透镜，还涉及用它制成的眼内透镜。
• Desiccating container for moisture-sensitive material
  申请人：West Pharmaceutical Services, Inc.

  公开号：US20030010668A1

  公开（公告）日：2003-01-16

  The present invention is to a container, particularly for moisture sensitive materials, having a container body of a substantially atmospheric moisture-impermeable material and incorporating a solid element which is made at least in part of a desiccating polymer and which is in contact with the atmosphere inside the container.

  本发明涉及一种容器，特别是用于装湿气敏感材料的容器，其容器体基本上是由不透气的湿气材料制成，并包含一个固体元件，该元件至少部分由干燥聚合物制成，并与容器内的大气接触。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。