(1-thiophen-3-yl)cyclohexanecarbonitrile | 55504-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (1-thiophen-3-yl)cyclohexanecarbonitrile
• 英文别名: 1-thiophen-3-ylcyclohexane-1-carbonitrile
• CAS: 55504-25-1
• 化学式: C₁₁H₁₃NS
• 分子量: 191.297
• InChiKey: WTCUEHYRBONNAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  52
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (1-thiophen-3-yl)cyclohexanecarbonitrile 在 氢氧化钾 作用下， 以 二乙二醇 为溶剂， 反应 6.0h， 以85%的产率得到1-thiophen-3-yl-cyclohexanecarboxylic acid
  参考文献：
  名称：

  De Cointet; Grossi; Pigerol, European Journal of Medicinal Chemistry, 1980, vol. 15, # 3, p. 223 - 227

  摘要：

  DOI：
• 作为产物：
  描述：

  3-噻吩乙腈 以67%的产率得到
  参考文献：
  名称：

  COINTET P. DE; GROSSI P.-J.; PIGEROL C.; BROLL M.; EYMARD P., EUR. J. MED. CHEM.-CHIM. THER., 1980, 15, NO 3, 223-227

  摘要：

  DOI：

文献信息

• [EN] INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME<br/>[FR] COMPOSÉS INDAZOLE UTILISÉS COMME INHIBITEURS DE KINASE ET MÉTHODE DE TRAITEMENT DU CANCER AVEC LESDITS COMPOSÉS
  申请人：UNIV HEALTH NETWORK

  公开号：WO2013053051A1

  公开（公告）日：2013-04-18

  The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

  本教学提供了由结构式（I）或（I'）表示的吲唑化合物或其药用可接受的盐。还描述了这些药物组合物及其用作蛋白激酶抑制剂的方法，如对乳腺癌细胞、结肠癌细胞和卵巢癌细胞具有抗癌活性的TTK蛋白激酶、极化样激酶4（PLK4）和极化激酶。
• INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME
  申请人：University Health Network

  公开号：US20140371202A1

  公开（公告）日：2014-12-18

  The present teaching provide indazole compounds represented by Structural Formulae (I) or (I′) or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.

  本教学提供由结构式（I）或（I'）所代表的吲唑化合物或其药学上可接受的盐。还描述了制备药物组合物和使用方法，作为蛋白激酶抑制剂，例如TTK蛋白激酶，极化样激酶4（PLK4）和极化激酶，对乳腺癌细胞，结肠癌细胞和卵巢癌细胞具有抗癌活性。
• Sulfonamides that activate ABA receptors
  申请人：The Regents of the University of California

  公开号：US10757937B2

  公开（公告）日：2020-09-01

  The present invention provides methods and compositions comprising agonist compounds that activate ABA receptors. In one aspect, the invention provides an agricultural formulation useful for inducing ABA responses in plant vegetative tissues, reducing abiotic stress in plants, and inhibiting germination of plant seeds. The compounds are also useful for inducing expression of ABA-responsive genes in cells that express endogenous or heterologous ABA receptors.

  本发明提供了包含激活 ABA 受体的激动剂化合物的方法和组合物。一方面，本发明提供了一种农用制剂，可用于诱导植物无性组织中的 ABA 反应，减少植物的非生物胁迫，抑制植物种子的萌发。这些化合物还可用于诱导表达内源或异源 ABA 受体的细胞中 ABA 反应基因的表达。
• SULFONAMIDES THAT ACTIVATE ABA RECEPTORS
  申请人：The Regents of the University of California

  公开号：US20170231224A1

  公开（公告）日：2017-08-17

  The present invention provides methods and compositions comprising agonist compounds that activate ABA receptors. In one aspect, the invention provides an agricultural formulation useful for inducing ABA responses in plant vegetative tissues, reducing abiotic stress in plants, and inhibiting germination of plant seeds. The compounds are also useful for inducing expression of ABA-responsive genes in cells that express endogenous or heterologous ABA receptors.
• US4108865A
  申请人：——

  公开号：US4108865A

  公开（公告）日：1978-08-22