2'-Hydroxy[1,1'-biphenyl]-3-carbaldehyde | 400746-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2'-Hydroxy[1,1'-biphenyl]-3-carbaldehyde
• 英文别名: 3-(2-hydroxyphenyl)benzaldehyde
• CAS: 400746-69-2
• 化学式: C₁₃H₁₀O₂
• mdl: MFCD06802844
• 分子量: 198.22
• InChiKey: CEJNWQOCHOWIBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] COMPOSITIONS FOR THE TREATMENT OF HYPERTENSION AND/OR FIBROSIS<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT DE L'HYPERTENSION ET/OU DE LA FIBROSE
  申请人：VECTUS BIOSYSTEMS PTY LTD

  公开号：WO2015039172A1

  公开（公告）日：2015-03-26

  The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of hypertension and/or fibrosis.

  本发明涉及新化合物及其在预防性和/或治疗高血压和/或纤维化的用途。
• [EN] COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS<br/>[FR] COMPOSITIONS POUR LE TRAITEMENT DE LA FIBROSE ET D'ÉTATS ASSOCIÉS À LA FIBROSE
  申请人：VECTUS BIOSYSTEMS LTD

  公开号：WO2016145479A1

  公开（公告）日：2016-09-22

  The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions.

  本发明涉及新颖化合物及其在预防及/或治疗纤维化和与纤维化相关病症的应用。
• [EN] COMPOUNDS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS AND SYNTHESIS OF THE SAME<br/>[FR] COMPOSÉS UTILES DANS LE TRAITEMENT DE TROUBLES MÉTABOLIQUES ET LEUR SYNTHÈSE
  申请人：UNIV NORTH CAROLINA

  公开号：WO2014165816A1

  公开（公告）日：2014-10-09

  The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

  本发明提供了式(I)化合物：其中变量X、Y、Z和R1如本文所述。本文所述的一些化合物是谷氨酸脱氢酶激活剂。本发明还涉及包含这些化合物的药物组合物、这些化合物和组合物在治疗代谢紊乱中的用途以及这些化合物的合成。
• Biaryl substituted triazoles as sodium channel blockers
  申请人：Chakravarty Prasun K.

  公开号：US20080171777A1

  公开（公告）日：2008-07-17

  Biaryl substituted triazole compounds represented by Formula I, II or III, or pharmaceutically acceptable salts thereof, and a process for making such compounds and salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.

  公式I，II或III所代表的取代联苯基三唑化合物，或其药学上可接受的盐，以及制造这些化合物和盐的方法。制药组合物包括有效量的本化合物，单独使用或与一个或多个其他治疗活性化合物结合，并带有药学上可接受的载体。治疗与钠通道活性相关或由其引起的疾病的方法，包括例如急性疼痛、慢性疼痛、内脏疼痛、炎性疼痛、神经病性疼痛、癫痫、肠易激综合征、抑郁症、焦虑症、多发性硬化症和躁郁症，包括单独使用或与一个或多个其他治疗活性化合物结合的本化合物的有效量的给药。给予局部麻醉的方法包括给予本发明化合物的有效量，单独使用或与一个或多个其他治疗活性化合物结合，并带有药学上可接受的载体。
• COMPOUNDS USEFUL FOR THE TREATMENT OF METABOLIC DISORDERS AND SYNTHESIS OF THE SAME
  申请人：NORTH CAROLINA CENTRAL UNIVERSITY

  公开号：US20160046560A1

  公开（公告）日：2016-02-18

  The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

  本发明提供了一些式子为(I)的化合物：其中变量X、Y、Z和R1如本文所述。其中一些化合物是谷氨酸脱氢酶激活剂。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在治疗代谢性疾病方面的用途以及化合物的合成。