3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one semicarbazone | 66050-56-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one semicarbazone
• 英文别名: 3,4,5,6,7,8-Hexahydro-2H-naphthalin-1-on-semicarbazon；(3,4,5,6,7,8-hexahydro-2H-naphthalen-1-ylideneamino)urea
• CAS: 66050-56-4
• 化学式: C₁₁H₁₇N₃O
• 分子量: 207.275
• InChiKey: ONCDPENKIBPNMA-UHFFFAOYSA-N

物化性质

• 熔点：
  243 °C
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,3,4,5,6,7-hexahydro-2H-[4a]naphthylamine 在 溶剂黄146 、 sodium nitrite 作用下， 生成 3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one semicarbazone
  参考文献：
  名称：

  Hueckel; Blohm, Justus Liebigs Annalen der Chemie, 1933, vol. 502, p. 114,135

  摘要：

  DOI：

文献信息

• Dietary Protein, Phosphorus and Potassium Are Beneficial to Bone Mineral Density in Adult Men Consuming Adequate Dietary Calcium
  作者：Susan J. Whiting、Jennifer L. Boyle、Angela Thompson、Robert L. Mirwald、Robert A. Faulkner

  DOI：10.1080/07315724.2002.10719242

  日期：2002.10

  Objective: The purpose of this study was to determine relationships of calcium (Ca), protein (Pr), phosphorus (P) and potassium (K) to measures of bone mineral density in adult men.Methods: Cross-sectional analysis of 57 men ages 39 to 42 years who were participants in an ongoing study. Dietary assessment was conducted using the Block food frequency questionnaire (FFQ). BMD of total body (TB), hip and lumbar spine (LS) were measured with dual X-ray absorptiometry (DXA).Results: Ca, Pr, P and K, as well as lean body mass (LBM), showed significant correlation with BMD at the total body, hip and lumbar spine. Stepwise forward regression selection method identified LBM. height and fat mass as significant predictors of TB-BMD, LBM and height as significant predictors of hip BMD, and LBM as a significant predictor of LS-BMD. As the nutrients tested correlated significantly with each other, only one nutrient was entered into the regression model at a time to accommodate the potential for multicollinearity. In regression analysis, adjusted for site-specific anthropometric variables and energy intake, K, Pr and P intake accounted for significant (p < 0.05) prediction of TB-BNID and LS-BMD values by 7% to 13%. No bone-related nutrient added significantly to the prediction of hip BMD. Ca intake was not significantly associated with BMD at any site in the adjusted models.Conclusions: Our analysis provides support that a moderate protein 0.2 g/kg) diet, plentiful in potassium (>100 mmol/day) and phosphorus (1741 +/- 535 mg) is beneficial for maintaining bone mineral density in adult men when Ca intake was adequate (1200 +/- 515 mg).
• Nenitzescu; Przemetzky, Chemische Berichte, 1941, vol. 74, p. 681
  作者：Nenitzescu、Przemetzky

  DOI：——

  日期：——
• 392. The synthesis of polyterpenoid compounds. Part II
  作者：J. W. Cook、C. A. Lawrence

  DOI：10.1039/jr9350001637

  日期：——
• Oxidation Products of Δ^9,10-Octalin
  作者：William P. Campbell、G. Chris Harris

  DOI：10.1021/ja01855a062

  日期：1941.10
• 1004. Reduced cyclic compounds. Part IX. The preparation of trans-deca-5,9-dienoic acid and its cyclisation to Δ⁹-octal-1-one
  作者：M. F. Ansell、J. W. Ducker

  DOI：10.1039/jr9600005219

  日期：——