3-(ethylamino)-5-methylphenol | 62988-21-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(ethylamino)-5-methylphenol
• CAS: 62988-21-0
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: MBLZYYOAVMDCFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(ethylamino)-5-methylphenol 在 zinc(II) chloride 作用下， 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of isomers of rhodamine 575 and rhodamine 6G as new laser dyes

  摘要：

  Two new laser dyes of the rhodamine family, substituted at C-l and C-8, were prepared by condensation of phthalic anhydride with 3-ethylamino-5-methylphenol. Two methodologies have been investigated for the preparation of the latter, (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00914-4
• 作为产物：
  描述：

  N-乙基苄胺 在 palladium on activated charcoal 甲酸 、 对甲苯磺酸 作用下， 以 甲醇 、 甲苯 为溶剂， 生成 3-(ethylamino)-5-methylphenol
  参考文献：
  名称：

  Synthesis of isomers of rhodamine 575 and rhodamine 6G as new laser dyes

  摘要：

  Two new laser dyes of the rhodamine family, substituted at C-l and C-8, were prepared by condensation of phthalic anhydride with 3-ethylamino-5-methylphenol. Two methodologies have been investigated for the preparation of the latter, (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00914-4

文献信息

• [EN] NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION<br/>[FR] FORMULATIONS DE FLUOROPHORE SPÉCIFIQUE AUX NERFS POUR ADMINISTRATION DIRECTE ET SYSTÉMIQUE
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2020033435A1

  公开（公告）日：2020-02-13

  Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

  描述了用于直接或全身给药的神经特异性荧光素配方。这些配方可用于荧光引导手术（FGS），帮助在外科手术干预期间保护神经。
• [EN] NEAR-INFRARED NERVE-SPARING FLUOROPHORES<br/>[FR] FLUOROPHORES ÉPARGNANT LES NERFS EN PROCHE INFRAROUGE
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2020023911A3

  公开（公告）日：2020-03-26
• NEAR-INFRARED NERVE-SPARING FLUOROPHORES
  申请人：Oregon Health & Science University

  公开号：EP3829420A2

  公开（公告）日：2021-06-09
• NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION
  申请人：Oregon Health & Science University

  公开号：EP3833401A1

  公开（公告）日：2021-06-16
• Synthesis of isomers of rhodamine 575 and rhodamine 6G as new laser dyes
  作者：Claudine Scala-Valéro、Denis Doizi、Gérald Guillaumet

  DOI：10.1016/s0040-4039(99)00914-4

  日期：1999.6

  Two new laser dyes of the rhodamine family, substituted at C-l and C-8, were prepared by condensation of phthalic anhydride with 3-ethylamino-5-methylphenol. Two methodologies have been investigated for the preparation of the latter, (C) 1999 Published by Elsevier Science Ltd. All rights reserved.