{3t-(5-nitro-[2]furyl)-1-[trans-2-(5-nitro-furyl)-vinyl]-allylidenamino}-guanidine; hydrochloride | 2315-20-0

• 物质功能分类: 化学试剂 - 有机试剂 - 腙
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: {3t-(5-nitro-[2]furyl)-1-[trans-2-(5-nitro-furyl)-vinyl]-allylidenamino}-guanidine; hydrochloride
• 英文别名: {3t-(5-Nitro-[2]furyl)-1-[trans-2-(5-nitro-furyl)-vinyl]-allylidenamino}-guanidin; Hydrochlorid；3-{3-(5-nitro-2-furyl)-1-[2-(5-nitro-2-furyl)vinyl]allylidene}carbazamidine monohydrochloride；2-[[(1E,4E)-1,5-bis(5-nitrofuran-2-yl)penta-1,4-dien-3-ylidene]amino]guanidine;hydron;chloride
• CAS: 2315-20-0
• 化学式: C₁₄H₁₂N₆O₆*ClH
• 分子量: 396.747
• InChiKey: ZEGPTFVBNBCAHZ-LMFJUDGVSA-N

物化性质

• 熔点：
  280℃
• 溶解度：
  二甲基亚砜（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  195
• 氢给体数：
  3
• 氢受体数：
  8

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335
• 储存条件：
  2-8°C

文献信息

• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
• US3985745A
  申请人：——

  公开号：US3985745A

  公开（公告）日：1976-10-12
• US3991124A
  申请人：——

  公开号：US3991124A

  公开（公告）日：1976-11-09
• US4160833A
  申请人：——

  公开号：US4160833A

  公开（公告）日：1979-07-10