α-deuterium-α-ethyl-2-hydroxy-6-methoxybenzenemethanol | 1352515-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: α-deuterium-α-ethyl-2-hydroxy-6-methoxybenzenemethanol
• CAS: 1352515-33-3
• 化学式: C₁₀H₁₄O₃
• 分子量: 183.211
• InChiKey: PIFOTMSVBBZWNC-WHRKIXHSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.84
• 重原子数：
  13.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  49.69
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  N,N-二甲基甲酰胺-d7 、 diethylzinc 、 三氟甲烷磺酸3-甲氧基-2-(三甲基硅基)苯酯 在 cesium fluoride 作用下， 以 正己烷 为溶剂， 反应 15.0h， 以52%的产率得到α-deuterium-α-ethyl-2-hydroxy-6-methoxybenzenemethanol
  参考文献：
  名称：

  Insertion of arynes into the carbon–oxygen double bond of amides and its application into the sequential reactions

  摘要：

  The reaction of arynes, generated from ortho-(trimethylsilyl)aryl triflates, with the C=O bond of formamides gave salicylaldehyde derivatives via the formation of formal [2+2] adducts. The sequential transformation of arynes into ortho-disubstituted arenes, o-aminoalkylphenols or o-hydroxyalkylphenols, was achieved by one-pot procedure using dialkylzincs. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.10.072

文献信息

• Insertion of arynes into the carbon–oxygen double bond of amides and its application into the sequential reactions
  作者：Eito Yoshioka、Hideto Miyabe

  DOI：10.1016/j.tet.2011.10.072

  日期：2012.1

  The reaction of arynes, generated from ortho-(trimethylsilyl)aryl triflates, with the C=O bond of formamides gave salicylaldehyde derivatives via the formation of formal [2+2] adducts. The sequential transformation of arynes into ortho-disubstituted arenes, o-aminoalkylphenols or o-hydroxyalkylphenols, was achieved by one-pot procedure using dialkylzincs. (C) 2011 Elsevier Ltd. All rights reserved.