(2R)-2-(Hexadecanoyloxy)-3-[(hydroxy{2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]ethoxy}phosphoryl)oxy]propyl hexadecanoate | 92605-64-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: (2R)-2-(Hexadecanoyloxy)-3-[(hydroxy{2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]ethoxy}phosphoryl)oxy]propyl hexadecanoate
• 英文别名: [(2R)-2-hexadecanoyloxy-3-[hydroxy-[2-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]ethoxy]phosphoryl]oxypropyl] hexadecanoate
• CAS: 92605-64-6
• 化学式: C43H75N4O11P
• 分子量: 855.0
• InChiKey: ODWMPKRLTCWGFP-DIPNUNPCSA-N

物化性质

• 沸点：
  861.3±75.0 °C(Predicted)
• 密度：
  1.124±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.2
• 重原子数：
  59
• 可旋转键数：
  41
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  205
• 氢给体数：
  2
• 氢受体数：
  14

文献信息

• FLUORESCENCE ASSAY FOR MTP ACTIVITY
  申请人：The Research Foundation of State University of New York

  公开号：EP1639125B1

  公开（公告）日：2009-09-16
• Fluoresence assay for mtp activity
  申请人：Hussain Mahmood M.

  公开号：US20060228764A1

  公开（公告）日：2006-10-12

  The present invention is directed to methods for assaying microsomal triglyceride transfer protein (MTP) which are amenable to automation and high-throughput screening. The assays may be used to measure MTP activity in cell and tissue homogenates as well as purified MTP. The methods provided by the present invention have the advantages of ease, rapidity, sensitivity, avoidance of the use of negatively charged lipids, versatility in studying different lipid transfer activities by purified and cellular MTP and the ability to measure inhibitory activity. In addition, methods of identifying compounds that modulate the lipid transfer activity of MTP are provided. Kits for measuring the lipid transfer activity of MTP are provided by the present invention
• Flourescence Assay for MTP Activity
  申请人：Hussain M. Mahmood

  公开号：US20090047700A1

  公开（公告）日：2009-02-19

  The present invention is directed to methods for assaying microsomal triglyceride transfer protein (MTP) which are amenable to automation and high throughput screening. The assays may be used to measure MTP activity in cell and tissue homogenates as well as purified MTP. Also provided are methods of measuring levels of lipids transferred by MTP. The methods provided by the present invention have the advantages of ease, rapidity, sensitivity, avoidance of the use of radioactivity, versatility in studying different lipid transfer activities by purified and cellular MTP and the ability to measure inhibitory activity. In addition, methods of identifying compounds that modulate the lipid transfer activity of MTP are provided. Kits for measuring the lipid transfer activity of MTP as well as net transfer of lipid by MTP are provided by the present invention.
• US5766626A
  申请人：——

  公开号：US5766626A

  公开（公告）日：1998-06-16
• US6099857A
  申请人：——

  公开号：US6099857A

  公开（公告）日：2000-08-08