p-tolyl-carbamic acid-(2-fluoro-ethyl ester) | 459-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-tolyl-carbamic acid-(2-fluoro-ethyl ester)
• 英文别名: p-Tolyl-carbamidsaeure-(2-fluor-aethylester)；2-fluoroethyl N-(4-methylphenyl)carbamate
• CAS: 459-15-4
• 化学式: C₁₀H₁₂FNO₂
• 分子量: 197.209
• InChiKey: LRGMUPBRRRMGKB-UHFFFAOYSA-N

物化性质

• 沸点：
  246.4±25.0 °C(Predicted)
• 密度：
  1.180±0.06 g/cm3(Predicted)
• 熔点：
  63 °C(Solv: ligroine (8032-32-4))

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氟乙醇 、 对甲苯异氰酸酯 生成 p-tolyl-carbamic acid-(2-fluoro-ethyl ester)
  参考文献：
  名称：

  NEW FLUORINATED URETHANS¹

  摘要：

  DOI：

  10.1021/jo01364a021

文献信息

• Methods for treating Hepatitis C
  申请人：Karp Mitchell Gary

  公开号：US20080096928A9

  公开（公告）日：2008-04-24

  In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

  根据本发明，已经确定了抑制病毒复制的化合物，优选为丙型肝炎病毒（HCV）复制，同时提供了其使用方法。在本发明的一方面，提供了用于治疗或预防病毒感染的化合物。在本发明的另一方面，提供了用于治疗或预防HCV感染的化合物。
• METHODS FOR TREATING HEPATITIS C
  申请人：KARP Gary M.

  公开号：US20110268698A1

  公开（公告）日：2011-11-03

  The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IBES activity.

  本发明提供了化合物、药物组合物以及使用这些化合物或组合物治疗病毒感染或影响病毒IBES活性的方法。
• Olah et al., Acta Chimica Academiae Scientiarum Hungaricae, 1956, vol. 7, p. 443,447
  作者：Olah et al.

  DOI：——

  日期：——
• Cross-Cultural Perspectives: Implications for Attachment Theory and Family Therapy
  作者：Patricia Minuchin

  DOI：10.1111/j.1545-5300.2002.41316.x

  日期：2002.9

  Cross‐cultural perspectives have always been useful for understanding behavior. They clarify the distinction between aspects that are essentially part of the human condition and those that are the most responsive to variation. The interesting article by Rothbaum and his colleagues is in that tradition, contrasting the cultural values and family patterns in Japanese society with those of Western cultures, including our own, and suggesting that these differences shape the nature and course of attachment. It stimulates questions about what we have taken for granted in our theories and in our evaluations of dysfunctional behavior.
• US7973069B2
  申请人：——

  公开号：US7973069B2

  公开（公告）日：2011-07-05