1,1-Bis[diethoxy(oxido)phosphaniumyl]-2-fluoroethanamine | 1351078-28-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: 1,1-Bis[diethoxy(oxido)phosphaniumyl]-2-fluoroethanamine
• 英文别名: 1,1-bis[diethoxy(oxido)phosphaniumyl]-2-fluoroethanamine
• CAS: 1351078-28-8
• 化学式: C₁₀H₂₄FNO₆P₂
• 分子量: 335.25
• InChiKey: VHLPIMYHKWEGNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  氟乙腈 、 亚磷酸二乙酯 在 二氯二茂钛 、 methyloxirane 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 以48%的产率得到1,1-Bis[diethoxy(oxido)phosphaniumyl]-2-fluoroethanamine
  参考文献：
  名称：

  Hydrophosphonylation of alkenes or nitriles by double radical transfer mediated by titanocene/propylene oxide

  摘要：

  Hydrophosphonylation reactions have emerged as efficient processes for the functionalization of alkenes or alkynes. Synthesis of alkylphosphonates was achieved by an original double radical transfer mediated by titanocene and propylene oxide. By the same way, nitriles which are considered as inert functions in radical process lead to aminobisphosphonates. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.09.096

文献信息

• Hydrophosphonylation of alkenes or nitriles by double radical transfer mediated by titanocene/propylene oxide
  作者：Camille Midrier、Mathias Lantsoght、Jean-Noël Volle、Jean-Luc Pirat、David Virieux、Christian V. Stevens

  DOI：10.1016/j.tetlet.2011.09.096

  日期：2011.12

  Hydrophosphonylation reactions have emerged as efficient processes for the functionalization of alkenes or alkynes. Synthesis of alkylphosphonates was achieved by an original double radical transfer mediated by titanocene and propylene oxide. By the same way, nitriles which are considered as inert functions in radical process lead to aminobisphosphonates. (C) 2011 Elsevier Ltd. All rights reserved.