4-(4-methylbenzyl)phenol | 28994-46-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-methylbenzyl)phenol
• 英文别名: 4-Hydroxy-4'-methyl-diphenylmethan；4-Hydroxy-4'-methyldiphenylmethan；4-(4-Methylbenzyl)-phenol；Phenol, 4-[(4-methylphenyl)methyl]-；4-[(4-methylphenyl)methyl]phenol
• CAS: 28994-46-9
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: GPLFFBUSCBMSNI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(4-methylbenzyl)phenol 生成 4-(4-Methylbenzyl)-phenyl-3,5-dinitrobenzoat
  参考文献：
  名称：

  ABDURASULEVA A. R.; AXMEDOV K. N.; RISKIBAEV EH. R.; YUSUPOV N. U., ZH. ORGAN. XIMII , 1975, 11, HO 8, 1665-1668

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基-4'-甲基二苯甲醇 在 乙醇 、 sodium 作用下， 生成 4-(4-methylbenzyl)phenol
  参考文献：
  名称：

  The Chemistry of Xylylenes. VII. Some Reactions of p-Xylylene that Occur via Cationic Intermediates²

  摘要：

  DOI：

  10.1021/ja01504a049

文献信息

• INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS
  申请人：Dumas Jacques

  公开号：US20120046290A1

  公开（公告）日：2012-02-23

  This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.

  本发明涉及一组芳香脲在治疗细胞因子介导的疾病（除癌症外）和蛋白水解酶介导的疾病（除癌症外）中的用途，以及用于此类治疗的药物组合物。
• BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION
  申请人：Sandanayaka Vincent

  公开号：US20070066820A1

  公开（公告）日：2007-03-22

  The present invention relates to a chemical genus of biaryl substituted heterocycle inhibitors of LTA4H (leukotriene A4 hydrolase) useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders. The compounds have general formula Ψ: An example is

  这项发明涉及一种化学类别的双芳基取代杂环抑制剂，用于治疗、预防和预防炎症性疾病和紊乱。这些化合物具有一般公式Ψ：一个例子是
• AMINOETHYLATION PROCESS HAVING IMPROVED YIELD OF ARYLOXYALKYLENE AMINE COMPOUNDS AND REDUCED UREA BY-PRODUCTS
  申请人：McDougall Patrick J.

  公开号：US20140073814A1

  公开（公告）日：2014-03-13

  Disclosed is a process for preparing an aryloxyalkylene amine compound via an aminoethylation reaction comprising: a) reacting an aromatic hydroxyl compound in the presence of a basic catalyst with a 2-oxazolidinone compound of the formula II to form an intermediate reaction product; wherein R 3 is selected from the group consisting of hydrogen or lower alkyl having 1 to 6 carbon atoms, R 4 is selected from the group consisting of hydrogen, straight or branched chain alkyl having from one to six carbon atoms, phenyl, alkaryl, or arylalkyl; and b) reacting the intermediate product of step a) with a polyalkylene polyamine.

  揭示了一种通过氨基乙基化反应制备芳基氧基烷胺化合物的过程，包括：a)在碱性催化剂存在下，将芳香羟基化合物与式II的2-噁唑烷酮化合物反应，形成中间反应产物；其中R3选自氢或1至6个碳原子的较低烷基，R4选自氢、一元或分支链烷基（含1至6个碳原子）、苯基、烷基芳基或芳基烷基；b)将步骤a）中间产物与聚烷基聚胺反应。
• FLAME RETARDANT MOLDING COMPOSITIONS
  申请人：Xue Siqi

  公开号：US20120029122A1

  公开（公告）日：2012-02-02

  Thermoplastic molding compositions, comprising A) from 10 to 98% by weight of a thermoplastic polymer, B) from 0.5 to 40% by weight of a flame retardant compound comprising phosphorus, C) from 0.5 to 35% by weight of iron sulfide, D) from 0 to 70% by weight of further additives, where the total of the percentages by weight of components A) to D) is 100%.

  热塑性模塑组合物，包括A）10至98重量％的热塑性聚合物，B）0.5至40重量％的含磷阻燃化合物，C）0.5至35重量％的硫化铁，D）0至70重量％的其他添加剂，其中组分A）至D）的重量百分比之和为100％。
• Inhibition Of Raf Kinase Using Substituted Heterocyclic Ureas
  申请人：DUMAS Jacques

  公开号：US20120129893A1

  公开（公告）日：2012-05-24

  Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.

  使用替代尿素化合物治疗由raf激酶介导的肿瘤的方法，以及这种化合物本身。