1H,2H,4H-pyrido[3,2-d][1,3]oxazin-2-one | 2027543-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1H,2H,4H-pyrido[3,2-d][1,3]oxazin-2-one
• 英文别名: 1,4-dihydropyrido[3,2-d][1,3]oxazin-2-one
• CAS: 2027543-40-2
• 化学式: C₇H₆N₂O₂
• 分子量: 150.13
• InChiKey: XQPJIIKEJHGAEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1H,2H,4H-pyrido[3,2-d][1,3]oxazin-2-one 生成 6-bromo-1,4-dihydro-2H-pyridino[3,2-d][1,3]oxaazin-2-one
  参考文献：
  名称：

  SPADA, ALFRED P.;STUDT, WILLIAM L.;CAMPBELL, HENRY F.;KUHLA, DONALD E.;TU+

  摘要：

  DOI：

文献信息

• [EN] 1H-IMIDAZO[4,5-c]QUINOLINONE DERIVATIVES<br/>[FR] DÉRIVÉS DE LA 1H-IMIDAZO[4,5-C]QUINOLINONE
  申请人：NOVARTIS AG

  公开号：WO2010139731A1

  公开（公告）日：2010-12-09

  The invention relates to the use of 1H-imidazo[4,5-c]quinolinone derivatives and salts thereof in the treatment of protein and/or lipid kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases; 1H-imidazo[4,5-c] quinolinone derivatives for use in the treatment of protein and/or lipid kinase dependent diseases; a method of treatment against said diseases, comprising administering the 1H- imidazo[4,5-c] quinofinone derivatives to a warm-blooded animal, especially a human; pharmaceutical preparations comprising an 1H-imidazo[4,5-c] quinolinone derivative, especially for the treatment of a protein and/or lipid kinase dependent disease; novel 1 H- imidazo[4,5-c] quinolinone derivatives; and a process for the preparation of the novel 1H- imidazo[4,5-c] quinolinone derivatives.

  该发明涉及在蛋白质和/或脂质激酶依赖性疾病的治疗中使用1H-咪唑并[4,5-c]喹啉酮衍生物及其盐，并用于制备用于治疗该等疾病的药物制剂；用于治疗蛋白质和/或脂质激酶依赖性疾病的1H-咪唑并[4,5-c]喹啉酮衍生物；一种治疗上述疾病的方法，包括向温血动物，特别是人类，施用1H-咪唑并[4,5-c]喹啉酮衍生物；包括1H-咪唑并[4,5-c]喹啉酮衍生物的药物制剂，特别用于治疗蛋白质和/或脂质激酶依赖性疾病；新颖的1H-咪唑并[4,5-c]喹啉酮衍生物；以及制备新颖的1H-咪唑并[4,5-c]喹啉酮衍生物的方法。
• Cyclic amide derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0468187A2

  公开（公告）日：1992-01-29

  The cyclic amide derivative is defined by the formula (I) or a salt thereof: R1-(CH2)n-Z in which R1 is a group derived from a cyclic amide compound, substituted or unsubstituted, n is zero or an integer of 1 to 10 and Z is R2 being an aryl, a substituted aryl, a cycloalkyl or a heterocyclic group, m being an integer of 1 to 6, R3 being hydrogen or a lower alkyl, R4 being an aryl or a substituted aryl, a cycloalkyl or a heterocyclic group, p being an integer of 1 to 6, provided that the cyclic amide compound is quinazoline-on or quinazoline-dion, R2 and R4 are neither aryl nor substituted aryl. The cyclic amide compound is pharmacologically effective to prevent and treat diseases due to insufficiency of the central choline functions.

  环酰胺衍生物由式 (I) 或其盐定义 或其盐：R1-(CH2)n-Z 其中 R1 是由环酰胺化合物衍生的基团，可取代或未取代，n 是零或 1 至 10 的整数，Z 是 R2 是芳基、取代的芳基、环烷基或杂环基，m 是 1 至 6 的整数，R3 是氢或低级烷基，R4 是芳基或取代的芳基、环烷基或杂环基，p 是 1 至 6 的整数，条件是环酰胺化合物是喹唑啉酮或喹唑啉二酮，R2 和 R4 既不是芳基也不是取代的芳基。环酰胺化合物对预防和治疗中枢胆碱功能不足引起的疾病具有药理作用。
• Agent for removing undifferentiated iPS cells
  申请人：Sumitomo Pharma Co., Ltd.

  公开号：US11434472B2

  公开（公告）日：2022-09-06

  The present invention provides a compound of formula (1) or a salt thereof wherein ring Q1 is optionally-substituted C6-10 aryl, etc.; R1 and R2 are independently hydrogen atom, etc.; W1 is C1-4 alkylene which may be optionally substituted with 1 to 3 fluorine atoms or C3-7 cycloalkyl; W2 is —NR4aC(O)—, etc. wherein R4a is hydrogen atom or C1-6 alkyl; ring Q2 is optionally-substituted C6-10 aryl, etc., which has an inhibitory effect on the sphere-forming ability of cancer cells and is useful an agent for removing iPS cells.

  本发明提供了式(1)化合物或其盐，其中环Q1为任选取代的C6-10芳基等；R1和R2独立地为氢原子等；W1为C1-4亚烷基，可任选被1至3个氟原子或C3-7环烷基取代；W2为-NR4aC(O)-等，其中R4a为氢原子或C1-6烷基；环Q2为任选取代的C6-10芳基等、其中 R4a 是氢原子或 C1-6 烷基；环 Q2 是任选取代的 C6-10 芳基等。
• PYRIDOOXAZINONE-PYRIDONE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES
  申请人：RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation)

  公开号：EP0357675A1

  公开（公告）日：1990-03-14
• EP0357675A4
  申请人：——

  公开号：EP0357675A4

  公开（公告）日：1992-01-15