L2-401-9 | 20354-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: L2-401-9
• 英文别名: 4-Methyl-2-phenyl-1,2,4-thiadiazolidine-3,5-dione
• CAS: 20354-13-6
• 化学式: C₉H₈N₂O₂S
• 分子量: 208.241
• InChiKey: KWKUDDYECAOINY-UHFFFAOYSA-N

物化性质

• 熔点：
  110-111 °C
• 沸点：
  303.8±25.0 °C(Predicted)
• 密度：
  1.411±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  65.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5,5-Dichloro-4-methyl-2-phenyl-[1,2,4]thiadiazolidin-3-one 以 水 为溶剂， 反应 0.17h， 生成 L2-401-9
  参考文献：
  名称：

  Slomczynska, Urszula; Barany, George, Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 241 - 246

  摘要：

  DOI：

文献信息

• SLOMCZYNSKA, U.;BARANY, G., J. HETEROCYCL. CHEM., 1984, 21, N 1, 241-246
  作者：SLOMCZYNSKA, U.、BARANY, G.

  DOI：——

  日期：——
• Small Molecule Modulators of pRb Inactivation
  申请人：The Wistar Institute of Anatomy and Biology

  公开号：US20140323442A1

  公开（公告）日：2014-10-30

  The present invention provides a small molecule treatment of diseases/conditions caused by a virus carrying a viral oncoprotein. In one embodiment, the virus which carries the viral oncoprotein is HPV. The small molecule useful herein includes thiadiazolin-3,5-dione compounds having an optionally substituted aryl group bound to one nitrogen atom of said thiadiazolin-3,5-dione compound. The small molecules may also be administered with a compound which inhibits binding of HPV E6 to p53. In one embodiment, the thiadiazolin-3,5-dione compound has formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R 1 and R 2 are defined herein.
• SMALL MOLECULE MODULATORS OF PRB INACTIVATION
  申请人：The Wistar Institute of Anatomy and Biology

  公开号：US20170000772A1

  公开（公告）日：2017-01-05

  The present invention provides a small molecule treatment of diseases/conditions caused by a virus carrying a viral oncoprotein. In one embodiment, the virus which carries the viral oncoprotein is HPV. The small molecule useful herein includes thiadiazolin-3,5-dione compounds having an optionally substituted aryl group bound to one nitrogen atom of said thiadiazolin-3,5-dione compound. The small molecules may also be administered with a compound which inhibits binding of HPV E6 to p53. In one embodiment, the thiadiazolin-3,5-dione compound has formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, or metabolite thereof, wherein R 1 and R 2 are defined herein.
• US8569346B1
  申请人：——

  公开号：US8569346B1

  公开（公告）日：2013-10-29
• US9447060B2
  申请人：——

  公开号：US9447060B2

  公开（公告）日：2016-09-20