2-Chloro-6-(2,4-dichlorophenoxy)phenol | 691883-23-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Chloro-6-(2,4-dichlorophenoxy)phenol
• CAS: 691883-23-5
• 化学式: C₁₂H₇Cl₃O₂
• 分子量: 289.5
• InChiKey: CYTRYZRMQHRCCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Peptide deformylase activated prodrugs
  申请人：——

  公开号：US20030091587A1

  公开（公告）日：2003-05-15

  This invention provides a method for inhibiting the growth of a microorganism that expresses Peptide Deformylase by contacting the microorganism with an effective amount of the compound described herein. This method inhibits the growth of gram-positive and gram-negative microorganism, e.g., S. aureus, S. epidermidis, K. pneumoniae, E. aerogenes, E. cloacae, M. catarrhalis, E. coli, E. faecalis, H. influenzae and P. aeruginosa . This method can be practiced in vitro, ex vivo and in vivo. Further provided is a method for alleviating the symptoms of an infection by a Peptide Deformylase expressing microorganism in a subject by administering or delivering to the subject an effective amount of the compound described above.

  本发明提供了一种通过接触微生物与本文所述化合物的有效量来抑制表达肽变形酶的微生物生长的方法。该方法可以抑制革兰氏阳性和革兰氏阴性微生物的生长，例如金黄色葡萄球菌、表皮葡萄球菌、肺炎克雷伯菌、空气发酵肠杆菌、克洛伊氏肠杆菌、痰液产生的杆菌、大肠杆菌、嗜肠球菌、流感嗜血杆菌和铜绿假单胞菌。该方法可以在体外、体外和体内实施。此外，本发明还提供了一种通过向受试者施用或输送上述化合物的有效量来减轻表达肽变形酶的微生物感染症状的方法。
• Methods for identifying therapeutic targets for treating infectious disease
  申请人：——

  公开号：US20030130179A1

  公开（公告）日：2003-07-10

  This invention provides methods and systems to identify enzymes that act as enzyme catalyzed therapeutic activators and the enzymes identified by these methods. Also provided by this invention are compounds activated by the enzymes as well as compositions containing these compounds.

  本发明提供了一种识别作为酶催化治疗活化剂的酶的方法和系统，以及通过这些方法识别的酶。本发明还提供了被这些酶激活的化合物以及含有这些化合物的组合物。
• Agents and method for the protection of coatings and wood and other non-living organic substrates from deterioration by micro-organisms
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0038109A2

  公开（公告）日：1981-10-21

  The agents protect coatings and wood and other non-living organic materials, in particular textiles, from deterioration by microorganisms. The agents contain at least one compound of the formula wherein X is nitrogen or a CH group and R1 is a radikal of the formula wherein Ar, R and Z are as defined in claim one, or an acid addition salt thereof. The metod provided comprises applying at least one compound as just specified to, or incorporating it in, the material to be protected, in an antimicrobially effective amount.

  这些制剂可保护涂料、木材和其他非生物有机材料，特别是纺织品，免受微生物的侵蚀。药剂中至少含有一种式如下的化合物 其中 X 是氮或 CH 基团，R1 是式中的 Radikal。 其中 Ar、R 和 Z 如权利要求 1 所定义，或其酸加成盐。 本发明提供的方法包括将至少一种上述化合物以有效的抗菌量施用到待保护材料上，或将其加入待保护材料中。
• Water-dilutable wood-preserving liquids
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0148526A1

  公开（公告）日：1985-07-17

  A water-dilutable wood-preserving liquid containing from 10% w/w to 80% w/w of a suitable solvent, from 20% w/w to 80% w/w of a suitable solubilizer and from 0.01% w/w to 10% w/w of an azole of formula or an acid-addition salt thereof.

  一种可用水稀释的木材防腐液，含有 10%（重量比）至 80%（重量比）的适当溶剂、 20%（重量比）至 80%（重量比）的适当增溶剂和 0.01%（重量比）至 10%（重量比）的式唑或其酸加成盐。 或其酸加成盐。
• Preservative formulations comprising an oxathiazine and amine oxides
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1273234A1

  公开（公告）日：2003-01-08

  The present invention relates to the use of amine oxides to enhance the activity of fungicidal formulations comprising a fungicidal oxathiazine compound. It also relates to formulations comprising a fungicidal oxathiazine compound which is bethoxazin and amine oxides. These formulations are useful for the protection of objects made of wood, thatch or the like, biodegradable material and textiles against deterioration due to the action of fungi.

  本发明涉及使用氧化胺来增强包含杀真菌噁噻嗪化合物的杀真菌制剂的活性。本发明还涉及由杀真菌的噁噻嗪化合物（即贝特嗪）和氧化胺组成的制剂。这些制剂可用于保护木材、茅草或类似材料制成的物体、可生物降解的材料和纺织品，使其免受真菌作用而变质。