2,4-Bis(4-methoxyphenyl)phenol | 103594-28-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-Bis(4-methoxyphenyl)phenol
• CAS: 103594-28-1
• 化学式: C₂₀H₁₈O₃
• 分子量: 306.361
• InChiKey: FNORKXFQICSOIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,3,6-trimethoxy-6-(4-methoxyphenyl)cyclohexa-1,4-diene 在 oxonium 作用下， 生成 2,4-Bis(4-methoxyphenyl)phenol
  参考文献：
  名称：

  氧化联苯的阳极氧化研究。某些功能化联苯的便捷合成路线

  摘要：

  氧化联苯的阳极氧化可产生苯基取代的喹啉醚缩酮，收率良好至优异。这些化合物是制备更高官能化联苯的有用底物。

  DOI：

  10.1016/s0040-4039(00)94963-3

文献信息

• DHTP Ligands for the Highly Ortho-Selective, Palladium-Catalyzed Cross-Coupling of Dihaloarenes with Grignard Reagents: A Conformational Approach for Catalyst Improvement
  作者：Shunpei Ishikawa、Kei Manabe

  DOI：10.1002/anie.200905544

  日期：2010.1.18

  Palladium catalysts bearing dihydroxyterphenylphosphine ligands (such as 1) are reported for the ortho‐selective cross‐coupling of Grignard reagents and dihaloarenes. The second hydroxy group onto the terphenylphosphine ligand dramatically improved the catalytic efficiency and expanded the scope of the reaction.

  据报道，带有二羟基三苯膦配体（如1）的钯催化剂可用于格氏试剂和二卤代芳烃的邻位选择性交叉偶联。三苯基膦配体上的第二个羟基大大提高了催化效率并扩大了反应范围。
• Ortho-selective Cross Coupling of Dibromophenols and Dibromoanilines with Grignard Reagents in the Presence of Palladium Catalysts Bearing Hydroxylated Oligoarene-type Phosphine
  作者：Shunpei Ishikawa、Kei Manabe

  DOI：10.1246/cl.2007.1304

  日期：2007.11.5

  p-Terphenylphosphines with a hydroxy group were used as ligands for palladium in the catalytic cross coupling of dibromophenols and dibromoanilines with Grignard reagents. High ortho-selectivity that cannot be achieved with other phosphine ligands was observed.

  具有羟基的对联苯基膦被用作钯的配体，在二溴酚和二溴苯胺与格里尼亚反应试剂的催化交叉偶联中使用。观察到其他膦配体无法实现的高邻位选择性。
• Hydroxylated terphenylphosphine ligands for palladium-catalyzed ortho-selective cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents
  作者：Shunpei Ishikawa、Kei Manabe

  DOI：10.1016/j.tet.2011.09.013

  日期：2011.12

  p-Terphenylphosphines bearing one or two hydroxy groups were used as ligands to palladium in the cross-coupling of dibromophenols, dibromoanilines, and their congeners with Grignard reagents. High ortho-selectivity that cannot be achieved using other phosphine ligands was observed. ortho-Preference was also observed in competitive cross-coupling reactions of two substrates. A significant effect of the concentration of the Grignard reagent on the ortho-selectivity was observed, when the hydroxylated terphenylphosphines were used. Kinetic studies on this effect showed that high concentrations of the Grignard reagent retard the cross-coupling reaction only at the para-position, but not at the ortho-position. (C) 2011 Elsevier Ltd. All rights reserved.
• Highly Ortho-Selective Cross-Coupling of Dichlorobenzene Derivatives with Grignard Reagents
  作者：Shunpei Ishikawa、Kei Manabe

  DOI：10.1021/ol702646s

  日期：2007.12.1

  Highly ortho-selective cross-coupling of dichlorobenzene derivatives with Grignard reagents was realized using a combination of Pd-2(dba)(3) and PCy3. Use of hydroxylated terphenylphosphines further improved the reactions of dichlorophenol and dichloroaniline.
• DESCHEPPER, R. E.;SWENTON, J. S., TETRAHEDRON LETT., 1985, 26, N 40, 4831-4834
  作者：DESCHEPPER, R. E.、SWENTON, J. S.

  DOI：——

  日期：——